Protein Alignment Met and hif1aa

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001295488.1
• Gene: hif1aa / 797150
• ZFINID: ZDB-GENE-080917-55
• Length: 717
• Species: Danio rerio
• Alignment Length: 755
• Identity: 146/755 - (19%)
• Similarity: 234/755 - (30%)
• Gaps: 280/755 - (37%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            :|....|.:.||.|.:....||:..:|.....:..|||.:|:|.|...|||:.:.......:...
Zfish    17 KEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLLNSDVLEKETA 81

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ...:..|                  :.::.||...|.|:..|.||.:|.:|.:.||..|.:|.|.
Zfish    82 LDTQWNG------------------SFLKALDGFLLVLSADGDIVYLSENVSKCLGLPQIELTGH 128

  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEE 232
            ::.:.|||.|.:.||:.|                                              .
Zfish   129 SVFEFTHPCDHEELREML----------------------------------------------A 147

  Fly   233 HRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERV 297
            ||.|..:...|.:.:                           |.|.:|:.
Zfish   148 HRFGLSKKSKDQNTN---------------------------RSFLLRMK--------------- 170

  Fly   298 KIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGI 362
                |                    .|..|.|..|:.:|:..|..            ....:|..
Zfish   171 ----C--------------------TLTSRGRTVNVKSASWKVLR------------CSGRIHTA 199

  Fly   363 SGNDIVLVAMARVLREERPPEETEGTVGLTIYRQ-PEPYQLE-------YHTRHLIDGSIIDCDQ 419
            .|          |.:|....:.|..|..:.|... |.|..:|       :.:||.:|.....||:
Zfish   200 DG----------VEKEVCEEKNTCSTYLVLICESIPHPANIEAPLDSRTFLSRHTLDMRFTYCDE 254

  Fly   420 RIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY-----------GESC---YRL 470
            ||..:.|:..::|...|.:.:.|..|               ||:           |:.|   |||
Zfish   255 RITELLGFDPEDVLQHSVYEYYHALD---------------SDHMTKTHHSLFVKGQVCTGQYRL 304

  Fly   471 LSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIK--------- 526
            |::.|.|::..|:..:..:..:::....:|||.:|......:::..:::..||.||
Zfish   305 LAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEHQEEVE 369

  Fly   527 ---AEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTL 588
               ||:..:....|....:..|.:.:      .|..|....|.||             :.|..||
Zfish   370 VTMAELKEEEKEMDKEDEECVQPVVQ------HNSLKGETEALTV-------------ADPVLTL 415

  Fly   589 TLEELAPSPTPALALVP-----PAPSS----VKSSISKSVSVVNVTAAR---------KFQQEHQ 635
            .: .:..|....|..:|     ..|||    ..|.:|...|.:|...|.         .|||...
Zfish   416 DI-NITDSAISVLTEIPLYNDVMLPSSDVLLPLSPLSPPCSSLNDDEASTGHLQHDQFPFQQSSD 479

  Fly   636 KQRER-----DRE---QLK----------ERTNSTQGV---IRQLSSCLS-----EAETASCI-- 672
            ..|.:     |.|   |||          :..:.||||   :..|:..:.     :..|.|.:
Zfish   480 SSRSQVDLPVDSELCDQLKPDHVEKHFSMDIESKTQGVGLDLEMLAPYIPMDDDFQLRTVSPVRP 544

  Fly   673 --LSPASSLSASEAPDTPDPHSNTSP------PPSLHTRP 704
              .||.|.|..     ||...:.|||      |.||...|
Zfish   545 MCSSPCSGLDL-----TPSSSTQTSPALSAATPDSLSCDP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	16/50 (32%)
		PAS	137..>186	CDD:238075	18/48 (38%)
		PAS_11	401..510	CDD:464214	28/129 (22%)
hif1aa	NP_001295488.1	bHLH_SF	11..79	CDD:469605	17/61 (28%)
		PAS	85..150	CDD:214512	23/128 (18%)
		PAS	236..335	CDD:238075	23/113 (20%)
		HIF-1	<519..541	CDD:463274	2/21 (10%)
		HIF-1a_CTAD	683..716	CDD:430212