Protein Alignment Met and npas3

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_012824098.2
• Gene: npas3 / 780104
• XenbaseID: XB-GENE-999791
• Length: 949
• Species: Xenopus tropicalis
• Alignment Length: 881
• Identity: 170/881 - (19%)
• Similarity: 282/881 - (32%)
• Gaps: 312/881 - (35%)

  Fly     2 AAPETGNTGSTGSAGS-------TGSGSGSGSGSGSSSDPANGREARNL------------AEKQ 47
            |.||.|...|.|:.||       ..|....|:....|:.||......||            |.:.
 Frog    18 APPEPGAARSAGANGSHQHNVPGVSSYQQRGASRPISACPAPCPPDLNLSLQALRKEKSRDAARS 82

  Fly    48 RRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKS----------------- 95
            ||.|.|....|||.::|..|..:.:|||.:::|.....|:::...|:.
 Frog    83 RRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFAGQGDPPWNLRIEGPPPNTSV 147

  Fly    96 ---ASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLL 157
               .|:||:........:..|          |:...::|.||.....|...|:.:.:|.:|...|
 Frog   148 KVIGSQRRRSPSSVAMDIFES----------HMGSHILQSLDGFVFALNQEGKFLYISETVSIYL 202

  Fly   158 GHCQSDLYGQNLLQITHPDDQDLLRQQL---IPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTS 219
            |..|.:|.|.::....||.|...:.:||   :|                   |.:...|.||:..
 Frog   203 GLSQVELTGSSMFDYVHPGDHVEMAEQLGMKLP-------------------PGRGLLSQSANDD 248

  Fly   220 GSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMD---RRCFTVRL 281
            |:.......::|                      ||.|..    ||....|..|   .|.|.:|:
 Frog   249 GASSASSSSQSE----------------------TPEPVE----ATSPGILPQDNSLERSFFIRM 287

  Fly   282 ARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAAT 346
                 ::..|:....:|..|                |.:: .:..|.|....|:
 Frog   288 -----KSTLTKRGVHIKSSG----------------YKVI-HVTGRLRLRVSLS----------- 319

  Fly   347 VPPQHDAIAQAALHGISGNDIV--LVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYH---T 406
                         ||.||...|  ||.:|..|   .||...|             .:::.|   |
 Frog   320 -------------HGRSGAGQVMGLVVVAHAL---PPPTINE-------------VRIDCHMFVT 355

  Fly   407 RHLIDGSIIDCDQRIGLVAGYMK-DEVRNLSPFC--FMHLDDV---RWVIVALRQMYDCNSDYGE 465
            |..:|.:||.|:.||   :.||. :.|..:...|  |:|.:||   |...:.|.....|.:.|
 Frog   356 RVNLDLNIIYCENRI---SDYMDLNAVDLMGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKY-- 415

  Fly   466 SCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQ------KVQEMKEKFSTI 524
              ||.:.:||.:|::.:...:.::..:....:.:.||.:|..:..:.      ::..:.||.|..
 Frog   416 --YRWMQKNGGYIWVQSCATISINAKNATERNIIWVNYILSLQEYKDIPMDIAQLPHLPEKTSES 478

  Fly   525 IKA------------------------------------EMPTQSSSPDL-----------PASQ 542
            .:.                                    :.|...|.||:           ..|:
 Frog   479 SETSDSDSDSKDNSEDNENPKSDGKGNHSEQSEDHEPDHKQPGPHSDPDMNCDEEGNSSSDACSE 543

  Fly   543 APQQLERIVLYLIENLQKSVDSAETVGGQG-MESLMDDGYSSPANTLTLEELAPSPTPALALVPP 606
            ..::.|...|...|.:.:. .....:||.| :::|      .|.: :.:|..|.|.|..     .
 Frog   544 ESEESEDCELRKAEEVMEQ-GGLSALGGIGALDAL------GPMH-IKVERYAESETDM-----R 595

  Fly   607 APSSVKSSISK------------SVSVVNVTAARKFQQEHQKQRERDRE--------QLKERTNS 651
            .|.|:.|..:|            .|.|..|.      ..||:::.|.|:        :.:....|
 Frog   596 GPDSLSSDSAKDSESGDEDEDDSGVRVAGVL------NRHQRRKRRRRKGAGPCGGRRRRLSGGS 654

  Fly   652 TQGVI--------RQLSSCLSEAETASCILS-------------------------PASSLSASE 683
            :.|.|        |.|.|  :...|.:|..|                         |...:|.:|
 Frog   655 SPGAIESSLGDPPRLLPS--TPPPTGACSSSSVLKIKTEMSEPINFDNDSSIWNFPPNREISRNE 717

  Fly   684 AP----DTPDPHSNTSPPPSLHTRPSVLHRTLTSTL 715
            :|    ..|....:.||.||....|..||.::..::
 Frog   718 SPYSMTKPPTGGEHFSPSPSSSAAPPALHVSIPDSV 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	17/62 (27%)
		PAS	137..>186	CDD:238075	14/51 (27%)
		PAS_11	401..510	CDD:464214	29/117 (25%)
npas3	XP_012824098.2	bHLH-PAS_NPAS3_PASD6	68..144	CDD:381575	16/75 (21%)
		PAS	169..230	CDD:214512	16/60 (27%)
		PAS_3	363..450	CDD:430001	22/93 (24%)