DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and SIM1

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_005059.2 Gene:SIM1 / 6492 HGNCID:10882 Length:766 Species:Homo sapiens


Alignment Length:702 Identity:129/702 - (18%)
Similarity:208/702 - (29%) Gaps:274/702 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            :|....|.:.||:|.|:...|||.::|..:..:.:|||.:::|..|..|:::.||.:        
Human     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPE-------- 58

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
             ||......:|....|.|....|...|:|.||.....:...|:|:.:|.:....||..|.:|.|.
Human    59 -GLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 122

  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEE 232
            ::.:..||.|.|         ::..:...||.:         ||         ..::|.|:|   
Human   123 SIYEYIHPADHD---------EMTAVLTAHQPY---------HS---------HFVQEYEIE--- 157

  Fly   233 HRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEA------- 290
                                                      |.|.:|:.....:..|       
Human   158 ------------------------------------------RSFFLRMKCVLAKRNAGLTCGGY 180

  Fly   291 ----------TRHY--ERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAE 343
                      .|.|  :....|||::.                                ..:.|.
Human   181 KVIHCSGYLKIRQYSLDMSPFDGCYQN--------------------------------VGLVAV 213

  Fly   344 AATVPPQHDAIAQAALHGISGNDIVLVA---MARVLREERPPEETEGTVGLTIYRQPEPYQL--- 402
            ..::||  .|:.:..||   .|..:..|   |..:..:.|..|       ||.|   ||..|   
Human   214 GHSLPP--SAVTEIKLH---SNMFMFRASLDMKLIFLDSRVAE-------LTGY---EPQDLIEK 263

  Fly   403 -EYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGES 466
             .||..|..|...:.|...:.||.|.:..:.                                  
Human   264 TLYHHVHGCDTFHLRCAHHLLLVKGQVTTKY---------------------------------- 294

  Fly   467 CYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVN-TLLDEEAGRQKVQEMKEKFSTIIKAEMP 530
             ||.|:::|.::::.:...:..:..|::.|..:.|| .|.|.|                      
Human   295 -YRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTE---------------------- 336

  Fly   531 TQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAP 595
                                    .:.||.|:|....              |.||.:.|     .
Human   337 ------------------------YKGLQLSLDQISA--------------SKPAFSYT-----S 358

  Fly   596 SPTPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLS 660
            |.||.:.   ......||.:|.|.|....:...::...|.::.|.|.:.....:..|.....|| 
Human   359 SSTPTMT---DNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQL- 419

  Fly   661 SCLSEAE------TASCI---LSPASSLSASEAPDTPDPHSNTSPPPSLHTR 703
              |..|:      .|||.   .|..|||....|.|    ||........||:
Human   420 --LDPADRPGSQHDASCAYRQFSDRSSLCYGFALD----HSRLVEERHFHTQ 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 16/50 (32%)
PAS 137..>186 CDD:238075 12/48 (25%)
PAS_11 401..510 CDD:464214 20/113 (18%)
SIM1NP_005059.2 bHLH-PAS_SIM1 1..71 CDD:381581 21/77 (27%)
PAS 88..>158 CDD:238075 21/141 (15%)
PAS_3 243..329 CDD:430001 22/130 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..431 18/88 (20%)
SIM_C 359..669 CDD:461963 29/117 (25%)
Nuclear localization signal. /evidence=ECO:0000250 368..387 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 528..563
Blue background indicates that the domain is not in the aligned region.

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