DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and HIF3A

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:XP_016882621.1 Gene:HIF3A / 64344 HGNCID:15825 Length:755 Species:Homo sapiens


Alignment Length:587 Identity:116/587 - (19%)
Similarity:186/587 - (31%) Gaps:207/587 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 APETGNTGSTGSAGSTGSGSG---SGSGSGSSSDPANGREARNLAEKQRRDKLNASIQELATMVP 64
            ||...:....|...|..:..|   |..|.|..|.....:|....|.:.||.:....:.:||..:|
Human    22 APTRNSHPGPGCTASPPAPPGWPFSQRGPGRWSTTELRKEKSRDAARSRRSQETEVLYQLAHTLP 86

  Fly    65 HAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTL 129
            .|...|..|||.:::|.....||:..:   .|:....:.|..|                      
Human    87 FARGVSAHLDKASIMRLTISYLRMHRL---CAAGEWNQVGAGG---------------------- 126

  Fly   130 MQLLDCCFL--------TLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLI 186
             :.||.|:|        .||..|.:..:|.:|.:.||..|.:|.|.::....||.||:.|:..|.
Human   127 -EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALT 190

  Fly   187 PRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYN 251
            |                                            :..|.|::.||..:      
Human   191 P--------------------------------------------QQTLSRRKVEAPTE------ 205

  Fly   252 RRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAA 316
                                   |||::|:.                                  
Human   206 -----------------------RCFSLRMK---------------------------------- 213

  Fly   317 NYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERP 381
                 |.|..|.|..|:.||...|.                   ..||:          :|..:|
Human   214 -----STLTSRGRTLNLKAATWKVL-------------------NCSGH----------MRAYKP 244

  Fly   382 PEETEGT-----------VGLTIYRQPEPYQLE-------YHTRHLIDGSIIDCDQRIGLVAGYM 428
            |.:|...           :.|.....|.|..||       :.:||.:|.....||.||..||||.
Human   245 PAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYS 309

  Fly   429 KDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESC---YRLLSRNGRFIYLHTKGFLEVDR 490
            .|::...|.:.::|..|...|..::..:.    ..|::.   ||.|:|:|.:::..|:..:....
Human   310 PDDLIGCSAYEYIHALDSDAVSKSIHTLL----SKGQAVTGQYRFLARSGGYLWTQTQATVVSGG 370

  Fly   491 GSNKVHSFLCVNTLLD--EEAGRQKVQEMKEKFS-TIIKAEMPTQSSSPDLPASQAPQQLERIVL 552
            ...:..|.:||:.|:.  ||.|.....|..|:.| ..|:...|:|..:|: |.........||:.
Human   371 RGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPN-PGDSLDTPGPRILA 434

  Fly   553 YL 554
            :|
Human   435 FL 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 15/50 (30%)
PAS 137..>186 CDD:238075 16/56 (29%)
PAS_11 401..510 CDD:464214 31/120 (26%)
HIF3AXP_016882621.1 bHLH-PAS_HIF3a_PASD7 56..118 CDD:381572 16/64 (25%)
PAS 139..>214 CDD:238075 25/186 (13%)
PAS_11 285..392 CDD:464214 29/110 (26%)
PHA03247 <415..755 CDD:223021 6/23 (26%)
HIF-1 565..595 CDD:463274
Blue background indicates that the domain is not in the aligned region.

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