DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and arnt2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_009301213.1	Gene:	arnt2 / 64277	ZFINID:	ZDB-GENE-001207-3	Length:	738	Species:	Danio rerio

Alignment Length:	739	Identity:	157/739 - (21%)
Similarity:	264/739 - (35%)	Gaps:	173/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAPETGNTGSTGSAG---STGSGSGSGSGSGSSSDPANG------REARNLAEKQRRDKLNASI 56
            |.....|..|...|||   ....|.|....|....|...|      ||..:..|::||:|:...|
Zfish    34 MTGAMPGRGGKRRSAGMDFDDEDGEGPSKFSRYDDDQIPGDKERYARENHSEIERRRRNKMTQYI 98

  Fly    57 QELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPN- 120
            .||:.|||..:..:|:.||..:||.|...::                .::|||.:::.....|:
Zfish    99 TELSDMVPTCSALARKPDKLTILRMAVSHMK----------------SMRGTGNTSTDGAYKPSF 147

  Fly   121 -PSLHLTDTLMQLLD-CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQ 183
             ....|...:::..| ..|:....:|:::.||.||..:|.|.||:.:|..|.:..||||.|.||:
Zfish   148 LTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNHPQSEWFGSTLFEQVHPDDVDKLRE 212

  Fly   184 QLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSG-SDLEEEEMETEEHRLGRQQGEADDDED 247
            ||                         |||.::.|.. .||:...::.|    |:|..
Zfish   213 QL-------------------------STSENSMTGRILDLKTGTVKKE----GQQSS------- 241

  Fly   248 HPYNRRTPSPRRMAHLATIDDRLRM---DRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSS 309
                                  :||   .||.|..|:...|...:   |....::....:|..:.
Zfish   242 ----------------------MRMCMGSRRSFICRMRCGSAPLD---HISLNRLSSMRKRYRNG 281

  Fly   310 L--TGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVLVAM 372
            |  :....|.|.:|          :......|......|:|.:.....|.:.:       .|||:
Zfish   282 LGPSKEGEAQYSVV----------HCTGYIKAWPPAGMTIPDEDTEAGQTSKY-------CLVAI 329

  Fly   373 ARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEV--RNL 435
            .|:       :.|...|.:.:.....|  .|:.:||..||.|...|.|...|.||...::  :::
Zfish   330 GRL-------QVTSSPVSMDMNGLSVP--TEFLSRHNSDGIITFVDPRCINVIGYQPQDLLGKDI 385

  Fly   436 SPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLC 500
            ..||  |.:|...:..:.:|:...........||...:|..::.:.|..|...:..|:::...:|
Zfish   386 LEFC--HPEDQSHLRESFQQVVKLKGQVLSVMYRFRMKNREWMLIRTSSFTFQNPYSDEIEYIIC 448

  Fly   501 VNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSA 565
            .||         .|::::::....::.......::.||  ||.|..   .|...:....||:|..
Zfish   449 TNT---------NVKQLQQQQQAELEVHQRDGLTAYDL--SQVPVS---GVSAGVHESGKSIDKT 499

  Fly   566 ETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALV-----PPAPSSVKSSISKS------V 619
            |::..|..:....|.|:. .:|...:.:.||.|.....:     |..|.....|.|.|      |
Zfish   500 ESLFSQERDPRFSDIYTG-ISTSEKKMMVPSSTSGGQQLYSQGSPFQPGHSGKSFSSSVIHVPGV 563

  Fly   620 SVVNVTAARKFQQEHQKQRE---------------RDREQLKERTNSTQGVIRQLSSCLSEAETA 669
            :.:..||....|...|..|:               ..::|:..::|..|      ||......:.
Zfish   564 NDIQSTAGSAGQNLSQISRQINTGQVSWSGNRPPFSGQQQIPAQSNKAQ------SSPFGIGSSH 622

  Fly   670 SCILSPASSLSASEAPDTPDPHSN 693
            |....| ||.|...:|.|..|..|
Zfish   623 SYQADP-SSYSPLSSPATSSPSGN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	18/48 (38%)
		PAS	137..>186	CDD:238075	20/48 (42%)
		PAS_11	403..510	CDD:291273	25/108 (23%)
arnt2	XP_009301213.1	HLH	80..132	CDD:278439	18/67 (27%)
		PAS	152..258	CDD:279347	38/163 (23%)
		PAS	155..219	CDD:214512	25/88 (28%)
		PAS_11	351..451	CDD:291273	23/101 (23%)
		PAS	351..447	CDD:238075	22/97 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840