DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and Clock

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001376183.1	Gene:	Clock / 60447	RGDID:	620271	Length:	864	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	136/681 - (19%)
Similarity:	238/681 - (34%)	Gaps:	236/681 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||.:|:|   .::|::||:.||:.:...||........:.....:
  Rat    36 RVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIR 97

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ...|.|.:|          :...|..:::.||..||.:...|.:|.||.:|..||.|..|||..|
  Rat    98 QDWKPTFLS----------NEEFTQLMLEALDGFFLAIMTDGSVVYVSETVTSLLEHLPSDLVDQ 152

  Fly   168 NLLQI----THPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLE-EEE 227
            ::...    .|.:...:|...|:..|                           |.:..||: :.:
  Rat   153 SIFNFIPEGEHSEVYKILSTHLLESD---------------------------SLTPEDLKSKNQ 190

  Fly   228 METEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATR 292
            :|...|.|   :|..|..|        ||.
  Rat   191 LEFCCHML---RGTIDPKE--------PST----------------------------------- 209

  Fly   293 HYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQA 357
             ||.|:..|.|:    ||...:.:.:......|:|:..                 |...|.:...
  Rat   210 -YEYVRFIGNFK----SLNSVSTSTHNGFEGTIQRTHR-----------------PSYEDRVCFV 252

  Fly   358 ALHGISGNDIVLVAMARVLRE----ERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCD 418
            |        .|.:|..:.::|    |.|.|                   |:.:||.::...:..|
  Rat   253 A--------TVRLATPQFIKEMCTVEEPNE-------------------EFTSRHSLEWKFLFLD 290

  Fly   419 QRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY--GESC-YRLLSRNGRFIYL 480
            .|...:.||:..||...|.:.:.|:||:.    :|.:.::....|  |:|| ||.|::..::|:|
  Rat   291 HRAPPIIGYLPFEVLGTSGYDYYHVDDLE----SLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWL 351

  Fly   481 HTKGFLEVDRGSNKVHSFLCVNTLL---DEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQ 542
            .|..::...:.:::....:|.:|::   :..|.|::              |:..:.|.|:..|.:
  Rat   352 QTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRR--------------ELGIEESLPETAADK 402

  Fly   543 APQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAP----SPTPALA- 602
            :                                 .|.|..:..||::|:|...    ||||:.:
  Rat   403 S---------------------------------QDSGSDNRINTVSLKEALERFDHSPTPSASS 434

  Fly   603 --------LVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQL 659
                    .....|||..:.|....|    |..|.....|:|..:| |.....::.::|.|
  Rat   435 RSSRKSSHTAVSDPSSTPTKIPTDTS----TPPRPHLPAHEKMTQR-RSSFSSQSINSQSV---- 490

  Fly   660 SSCLSEAETASCILSPASSLSASEAPDTPDP 690
                     .|.:..||    .|:|.:.|.|
  Rat   491 ---------GSSLTQPA----MSQAANLPIP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	19/48 (40%)
		PAS	137..>186	CDD:238075	16/52 (31%)
		PAS_11	403..510	CDD:291273	26/112 (23%)
Clock	NP_001376183.1	bHLH-PAS_CLOCK	29..89	CDD:381577	21/55 (38%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O08785	32..47		5/10 (50%)
		PAS	109..202	CDD:395786	28/122 (23%)
		PAS_11	274..377	CDD:405306	27/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..497		28/159 (18%)
		Interaction with SIRT1. /evidence=ECO:0000250\|UniProtKB:O08785	450..570		18/81 (22%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840