DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and arntl1a

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_571652.1	Gene:	arntl1a / 58098	ZFINID:	ZDB-GENE-000509-1	Length:	626	Species:	Danio rerio

Alignment Length:	722	Identity:	155/722 - (21%)
Similarity:	247/722 - (34%)	Gaps:	244/722 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TGNTGSTG------SAGSTGSGSGSGSGSGSSSDP---------------ANGREARNLAEKQRR 49
            :.:.|:||      ..|||......|.....|.|.               .|.|||.:..||:||
Zfish    25 SSSIGTTGMDYNRKRKGSTTEYQIDGFSFDDSMDTDKDKTLGRDEQQGRIKNAREAHSQIEKRRR 89

  Fly    50 DKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASP 114
            ||:|:.|.|||::||.....||:|||..|||.|...::.                |:|   :.:|
Zfish    90 DKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT----------------LRG---ATNP 135

  Fly   115 VGDLPNPSLHLTD-----TLMQLLDCCFLTLTCS-GQIVLVSTSVEQLLGHCQSDLYGQNLLQIT 173
            ..:.......|:|     .:::..|.....:.|. |:|:.||.||.::|.:.|:||.||:|....
Zfish   136 YTEANYKPAFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVYKILNYTQNDLIGQSLFDYL 200

  Fly   174 HPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQ 238
            ||.|...:::||                                 |.||....|      ||
Zfish   201 HPKDIAKVKEQL---------------------------------SSSDTAPRE------RL--- 223

  Fly   239 QGEADDDEDHPYNRR-TPSPRRMAHLATIDDRLRMDRRCFTVRLA--RASTRAE-----ATRHYE 295
               .|.....|.... ||.|.|:...|         ||.|..|:.  |.|.:.|     :|  ..
Zfish   224 ---IDAKTGLPVKTDITPGPSRLCSGA---------RRSFFCRMKCNRPSVKMEDKDFPST--CS 274

  Fly   296 RVKIDGCFRRSDSSL-TGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAAL 359
            :.|.|   |:|..:: :.|...::|.....:.....                  |.::..
Zfish   275 KKKAD---RKSFCTIHSTGYLKSWPPTKMGLDEDNE------------------PDNEGC----- 313

  Fly   360 HGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLV 424
                 |...|||:.| |.....|:...|.:      :.:|  .||.:||.|||..:..|||...:
Zfish   314 -----NLSCLVAIGR-LHPHIVPQPMNGDI------RVKP--TEYVSRHAIDGKFVFVDQRATAI 364

  Fly   425 AGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVD 489
            ..|:..|:...|.:.:.|.||:..:....||:.........:||:...::|.||.|.::.|..::
Zfish   365 LAYLPQELLGTSFYEYFHQDDIGHLAECHRQVLQMREKISTNCYKFKIKDGSFITLRSRWFSFMN 429

  Fly   490 RGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYL 554
            ..:.:|...:..||::.               .::::...|:.|.:...|
Zfish   430 PWTKEVEYIVSTNTVVS---------------GSMLEGADPSYSQTASSP--------------- 464

  Fly   555 IENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSV 619
                 :|:||..|.|        |.|...|                |.:||..|...::...|
Zfish   465 -----QSMDSVLTSG--------DGGGKRP----------------LQIVPGIPGGTRAGAGK-- 498

  Fly   620 SVVNVTAARKFQQEHQK-QRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSASE 683
                  ..|...:|..: ||.|.                        :..:||..||. :::|:.
Zfish   499 ------IGRMIAEEVMEIQRIRG------------------------SSPSSCGSSPL-NITATP 532

  Fly   684 APDTPDP 690
            .|||..|
Zfish   533 PPDTCSP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	25/48 (52%)
		PAS	137..>186	CDD:238075	18/49 (37%)
		PAS_11	403..510	CDD:291273	28/106 (26%)
arntl1a	NP_571652.1	HLH	78..130	CDD:278439	25/67 (37%)
		PAS	150..257	CDD:279347	37/160 (23%)
		PAS	153..212	CDD:214512	18/58 (31%)
		PAS_11	343..446	CDD:291273	28/102 (27%)
		PAS	345..440	CDD:238075	24/94 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840