DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and BMAL2

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_001381453.1 Gene:BMAL2 / 56938 HGNCID:18984 Length:647 Species:Homo sapiens


Alignment Length:623 Identity:132/623 - (21%)
Similarity:219/623 - (35%) Gaps:170/623 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 STGSGSGSGSGSGSSSDPANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRF 81
            |..|||....|.......| .|||.:..||:||||:|..|:||:.|:|.....:|:|||..|||.
Human   100 SASSGSRVEDGEHQVKMKA-FREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRM 163

  Fly    82 ATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPNPSL----HLTDTLMQLLDCCFLTLTC 142
            |...||                .||  |::.|.||....||.    .|...:::..:.....:.|
Human   164 AVQHLR----------------SLK--GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGC 210

  Fly   143 S-GQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHN 206
            . |:|:.||.||.::|.:.|:.|.||:|....||.|...:::||...||               :
Human   211 ERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDI---------------S 260

  Fly   207 PQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDD--- 268
            |:                       |..:..:.|.......|....|..|..|.:....|..   
Human   261 PR-----------------------EKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKI 302

  Fly   269 RLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNM 333
            .::.:..|.      .:::.:..|.:..:...|..|....::.|         .:..|.|:.:| 
Human   303 SVKEEHGCL------PNSKKKEHRKFYTIHCTGYLRSWPPNIVG---------MEEERNSKKDN- 351

  Fly   334 LAAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPE 398
                                          .|...|||:.|:.....|....|..|..|      
Human   352 ------------------------------SNFTCLVAIGRLQPYIVPQNSGEINVKPT------ 380

  Fly   399 PYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY 463
                |:.||..::|..:..|||...:.||:..|:...|.:.:.|.||...:....:.:.......
Human   381 ----EFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKI 441

  Fly   464 GESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLL------------------DEEAG 510
            ....|:..:::|.|:.|.::.|...:..:.::...:.||||:                  .||:.
Human   442 LTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESS 506

  Fly   511 RQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKS--VDSAETVGGQGM 573
            ||...            .:|..|:...|.|......:...:|.| :.||.|  :|.:...|    
Human   507 RQSCM------------SVPGMSTGTVLGAGSIGTDIANEILDL-QRLQSSSYLDDSSPTG---- 554

  Fly   574 ESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSV 611
              ||.|.::....:::.:|          |.||:||.:
Human   555 --LMKDTHTVNCRSMSNKE----------LFPPSPSEM 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 25/50 (50%)
PAS 137..>186 CDD:238075 17/49 (35%)
PAS_11 401..510 CDD:464214 25/126 (20%)
BMAL2NP_001381453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..73
Interaction with PER2. /evidence=ECO:0000250|UniProtKB:Q2VPD4 57..269 62/225 (28%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9WTL8 60..65
bHLH-PAS_ARNTL2_PASD9 119..178 CDD:381475 28/76 (37%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:Q9WTL8 188..198 1/9 (11%)
PAS 203..298 CDD:238075 27/132 (20%)
PAS_11 381..483 CDD:464214 22/101 (22%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:Q9WTL8 403..411 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

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