Protein Alignment Met and sim1b

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001153057.1
• Gene: sim1b / 566656
• ZFINID: ZDB-GENE-041210-5
• Length: 586
• Species: Danio rerio
• Alignment Length: 750
• Identity: 143/750 - (19%)
• Similarity: 238/750 - (31%)
• Gaps: 277/750 - (36%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            :|....|.:.||:|.|:...|||.|:|..:..:.:|||.:::|..:..|:::.||.:.......:
Zfish     2 KEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMRLVFPQGLGEVWGQ 66

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQL--------LDCCFLTLTCSGQIVLVSTSVEQLLGH 159
            .|...:|         .|||..|...|:|:        ||.....:...|:|:.:|.:....||.
Zfish    67 AGRTRSG---------ENPSHELGSHLLQVIISKMLQTLDGFIFVVAADGKIMYISETASVHLGL 122

  Fly   160 CQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLE 224
            .|.:|.|.::.:..||.|.|.:...|.|:                  |..||         ..::
Zfish   123 SQVELTGNSIYEYVHPADHDEMAAVLTPQ------------------PSYHS---------HFVQ 160

  Fly   225 EEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAE 289
            |.|:|                                             |.|.:|:.....:..
Zfish   161 EYEVE---------------------------------------------RSFFLRMKCVLAKRN 180

  Fly   290 A---TRHYERVKIDGCFR----RSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATV 347
            |   :..|:.:...|..:    ..|:|...|...|..:|                    |...|:
Zfish   181 AGLTSGGYKVIHCSGYLKIRQFSLDASPFDGCYQNVGLV--------------------AVGHTL 225

  Fly   348 PPQHDAIAQAALHGISGNDIVLVA---MARVLREERPPEETEGTVGLTIYRQPEPYQL----EYH 405
            ||  .|:.:..||   .|..:..|   |..:..:.|..:       ||.|   ||..|    .||
Zfish   226 PP--SAVTEIKLH---SNMFMFRASLDMKLIFLDSRVSD-------LTGY---EPQDLIEKTLYH 275

  Fly   406 TRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRL 470
            ..|..|...:.|...:.||.|.:..:.                                   ||.
Zfish   276 HVHCCDSFHLRCAHHLLLVKGQVTTKY-----------------------------------YRF 305

  Fly   471 LSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGR------QKVQEMKEKF-------- 521
            ||:.|.::::.:...:..:..|::.|..:.||.:|.:...:      .::...|..|
Zfish   306 LSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQLNPRKPAFPYANHSDK 370

  Fly   522 -------STIIKAEMPTQSSS--PD--------------LPASQAPQQLER---IVLYLIE-NLQ 559
                   |.|:.:....|.||  ||              |..|.:||:|:|   :...|.: ::.
Zfish   371 THTTNSRSKILLSHYSQQFSSFPPDRSDSDHDSQWEDSPLTDSASPQRLDRSDSVCFSLAQSDVM 435

  Fly   560 KSVDSAET------------VGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVK 612
            :|.....|            ...|...::.|:..||.:        |.|...|.:|:..||..:
Zfish   436 QSCSQTHTPLFNRDGWWDARAANQHSHAVWDEDLSSSS--------AQSADGAQSLIRAAPELI- 491

  Fly   613 SSISKSVSVVNVTAARKFQQEHQKQRERDR--EQLKERTNSTQGVIRQLSSCLSEAETASCILSP 675
                            |.::.|.:......  ...:.|.....|                   ||
Zfish   492 ----------------KVEEAHMRDYSSSSLFSSARHRDGDPDG-------------------SP 521

  Fly   676 ASSLSASEAP--DTPDPHSNTSPP--PSLHTRPSV 706
            | ||||..:|  |.|....:.|||  .:.||.||:
Zfish   522 A-SLSALSSPGSDRPSQPLSASPPALETTHTHPSL 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	16/50 (32%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	19/112 (17%)
sim1b	NP_001153057.1	bHLH-PAS_SIM1	1..70	CDD:381581	19/67 (28%)
		PAS	92..148	CDD:214512	14/55 (25%)
		PAS_11	99..205	CDD:464214	26/177 (15%)
		PAS_3	251..337	CDD:430001	22/130 (17%)
		SIM_C	357..>498	CDD:461963	29/165 (18%)