DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and ncoa1

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_021324335.1	Gene:	ncoa1 / 563288	ZFINID:	ZDB-GENE-041001-175	Length:	1349	Species:	Danio rerio

Alignment Length:	767	Identity:	151/767 - (19%)
Similarity:	238/767 - (31%)	Gaps:	257/767 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SGSGSSSDPANGREARN-----------LAEKQRRDKLNASIQELATM----VPHAAESSRRLDK 75
            |.:|.::...|..|:|.           ..||:||:.....|.|||.:    :...|..:.:.||
Zfish     5 SAAGENALDPNILESRKRKGSPCDTSGPSVEKRRRELECRYIDELAELLSANMSDIASLNVKPDK 69

  Fly    76 TAVLRFATHGLRLQYVFGKSASRRRKKTG--------LKGTGMSASPVGDLPNPSLHLTDTLMQL 132
            ..:|:....  ::|.:     .||.::..        ::.:.:|:|..|.:...:  |...|::.
Zfish    70 CHILKSTVD--QIQQI-----KRREQENAALMSPNDEVQQSDISSSSHGMVEKEA--LGPLLLEA 125

  Fly   133 LDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQH 197
            ||..|..:...|:||.||.:|...||:.|.:|...::..|.|..|.:...:.|:|:   :|....
Zfish   126 LDGFFFVVNREGRIVFVSENVTGYLGYTQEELMTSSVYSILHVGDHNEFVRILLPK---SLVNGV 187

  Fly   198 QHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAH 262
            ...|:||   :::|.:.:........:|.:.|.:|   .|||.|.
Zfish   188 PWSQEQG---RRNSHTFNCRLLKRPPDEVDSENQE---ARQQYEL-------------------- 226

  Fly   263 LATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQL--- 324
                       .:||||...:|...       |...:..|..        ..|...|...|:
Zfish   227 -----------MQCFTVSQPKALQE-------EGEDLQSCLI--------CIACQIPRPPQIPVS 265

  Fly   325 ----IRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQA--ALHGISGNDIVLVAMARVLREERPPE 383
                |.:......:.:....|..|...|...|.:.:.  |.....||:   .:.|:.|..|
Zfish   266 TESFITKQDPTGKIISIETSALRATGRPGWEDLVRKCIYAFFQPQGNE---PSHAKKLLHE---- 323

  Fly   384 ETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRW 448
              ..|.|:.|    .|.   ||.. |.||:.:....|               ..||.....||:.
Zfish   324 --VMTHGMAI----SPL---YHFT-LSDGTSLSAQTR---------------CKFCCPQNPDVQP 363

  Fly   449 VIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQK 513
            .|:                                ||..:||..|
Zfish   364 FIM--------------------------------GFHTIDREHN-------------------- 376

  Fly   514 VQEMKEKFSTIIKAEMPTQS-SSPDLPASQAPQQLERIVLYLIENLQKSVD-------SAETVGG 570
                     |....|..|.| |||..|.|::|.            ||.|.|       :..|...
Zfish   377 ---------TASSQENTTPSLSSPAAPPSRSPA------------LQPSSDLSIHLNNTNGTCAT 420

  Fly   571 QGMESLMDDGYSSPANTLTLEEL-APSP-------TPALALVPPAPSSVKSSISKSVSVVNVTAA 627
            .|..:....||.:|:.....::: :|||       ||. :.:.|.|......::.|..|.....:
Zfish   421 PGPLTPTPPGYLTPSRVGPSQQVSSPSPLGSPLTATPT-SFMSPRPPRGSPGLASSPRVPGHPFS 484

  Fly   628 RKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPA---------------- 676
            ......|.......|:|     :...||...|.|.|...:|.:...|||
Zfish   485 PSTPSIHSPAGGLTRQQ-----SGGDGVGFSLPSPLPPRQTPTPSSSPARQPPAKPPEASNDEPK 544

  Fly   677 -------------SSLSASEAPDTPDPHSNTSPPPSLHT----RPSVLHRTL 711
                         ...||.|....|.| |.||..|:.|:    |..:|||.|
Zfish   545 SNQVGNPKLSQLLDGASAPEQDSQPRP-SPTSQCPASHSSLTERHKILHRLL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	14/63 (22%)
		PAS	137..>186	CDD:238075	14/48 (29%)
		PAS_11	403..510	CDD:291273	16/106 (15%)
ncoa1	XP_021324335.1	HLH	35..89	CDD:197674	15/60 (25%)
		PAS	121..178	CDD:214512	17/56 (30%)
		PAS_11	267..376	CDD:317051	30/172 (17%)
		Atrophin-1	<384..670	CDD:331285	53/231 (23%)
		Nuc_rec_co-act	869..913	CDD:312376
		DUF1518	1150..1206	CDD:311422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900