Protein Alignment Met and Hif3a

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001156422.1
• Gene: Hif3a / 53417
• MGIID: 1859778
• Length: 664
• Species: Mus musculus
• Alignment Length: 725
• Identity: 130/725 - (17%)
• Similarity: 218/725 - (30%)
• Gaps: 286/725 - (39%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            :|....|.:.||.:....:.:||..:|.|...|..|||.:::|.....||:..:.......:.:|
Mouse    16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVEK 80

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFL--------TLTCSGQIVLVSTSVEQLLGH 159
            .|                          :.||.|:|        .||..|.:..:|.:|.:.||.
Mouse    81 GG--------------------------EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGL 119

  Fly   160 CQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLE 224
            .|.:|.|.::....||.||:.|:..|.||                                .:|.
Mouse   120 SQLELIGHSIFDFIHPCDQEELQDALTPR--------------------------------PNLS 152

  Fly   225 EEEME--TEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTR 287
            ::::|  ||.|                                           |::|:.
Mouse   153 KKKLEAPTERH-------------------------------------------FSLRMK----- 169

  Fly   288 AEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHD 352
                                              |.|..|.|..|:.||...|
Mouse   170 ----------------------------------STLTSRGRTLNLKAATWKV------------ 188

  Fly   353 AIAQAALHGISGNDIVLVAMARVLREERPPEETEGT-----------VGLTIYRQPEPYQLE--- 403
                  || .||:          :|..:||.:|...           :.|.....|.|..||
Mouse   189 ------LH-CSGH----------MRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPL 236

  Fly   404 ----YHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYG 464
                :.:||.:|.....||:||..||||..|::...|.:.::|..|...|..::..:.    ..|
Mouse   237 GRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLL----SKG 297

  Fly   465 ESC---YRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLD--EEAGRQKVQEMKEKFSTI 524
            ::.   ||.|:|.|.:::..|:..:.......:..|.:||:.|:.  ||.|.....|..|:.:.
Mouse   298 QAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEETGVVLSLEQTEQHTR- 361

  Fly   525 IKAEMPTQSSSPDLPASQAPQQLERIVLYL----IENLQKSVDSAETVGGQGMESLMDDGYSSPA 585
             :....:.||...:|.:.......||:.:|    :.....:.|...              :.||.
Mouse   362 -RPPRLSASSQKGIPGNSVDSPAPRILAFLHPPALSEASLAADPRR--------------FCSPD 411

  Fly   586 NTLTLEELAPSPTPALALVPPAP-------SSVKSSISKSVSVVNVTAARKFQQEHQKQRERDRE 643
            ....:..:...|.|  |..|..|       |.:.:.:...::|....|.|....:..|..|.|
Mouse   412 LRRLMAPILDGPPP--AATPSTPQATRRPQSPLPADLPDKLTVGLENAHRLSTAQKNKTVETD-- 472

  Fly   644 QLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSASEAPDTPD-----PH---------SNT 694
                                               |..::.|||.|     |:         :::
Mouse   473 -----------------------------------LDIAQDPDTLDLEMLAPYISMDDDFQLNSS 502

  Fly   695 SPPPSLHTRP 704
            ...|.:|.||
Mouse   503 EQLPKVHRRP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	15/50 (30%)
		PAS	137..>186	CDD:238075	16/56 (29%)
		PAS_11	401..510	CDD:464214	31/120 (26%)
Hif3a	NP_001156422.1	bHLH-PAS_HIF3a_PASD7	12..74	CDD:381572	15/57 (26%)
		PAS	90..145	CDD:214512	16/54 (30%)
		PAS_3	251..338	CDD:430001	22/90 (24%)
		HIF-1	475..506	CDD:463274	5/30 (17%)