DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and NPAS2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_005264010.1	Gene:	NPAS2 / 4862	HGNCID:	7895	Length:	889	Species:	Homo sapiens

Alignment Length:	730	Identity:	161/730 - (22%)
Similarity:	258/730 - (35%)	Gaps:	216/730 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||::|:|   .::|::|||.||                    .|.
Human    76 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVL--------------------EKV 117

  Fly   103 TGL--KGTGMSA-SPVGDLP---NPSL----HLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLL 157
            .|.  |...:|| :.:.|:.   .||.    ..|..:::.||...:.:|..|.|:.||.|:..||
Human   118 IGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLL 182

  Fly   158 GHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQ-----QGHNPQQHSTSTSAS 217
            ||..||:..||||.                      |...|.|.:     ..|.....|.|....
Human   183 GHLPSDVMDQNLLN----------------------FLPEQEHSEVYKILSSHMLVTDSPSPEYL 225

  Fly   218 TSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLA 282
            .|.||||                                                    |...|.
Human   226 KSDSDLE----------------------------------------------------FYCHLL 238

  Fly   283 RASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATV 347
            |.|...:....||.:|..|.||..:         |.|..|    .:..:|.|:....|..
Human   239 RGSLNPKEFPTYEYIKFVGNFRSYN---------NVPSPS----CNGFDNTLSRPCRVPL----- 285

  Fly   348 PPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDG 412
                            |.::..:|..|:...:...|       :.|..:|..   |:.:||.::.
Human   286 ----------------GKEVCFIATVRLATPQFLKE-------MCIVDEPLE---EFTSRHSLEW 324

  Fly   413 SIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGES-CYRLLSRNGR 476
            ..:..|.|...:.||:..||...|.:.:.|:||:.  ::|....:......|:| |||.|::..:
Human   325 KFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLE--LLARCHQHLMQFGKGKSCCYRFLTKGQQ 387

  Fly   477 FIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGR-QKVQE---------------MKEKFSTII 525
            :|:|.|..::...:.::|....:|.::::.....| ::.||               :|:|.|::
Human   388 WIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSL- 451

  Fly   526 KAEMPTQS------SSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSP 584
               .|.|.      .:..|..|.:|....|       :..||..:|.:........||.:. |:|
Human   452 ---EPRQHFNTLDVGASGLNTSHSPSASSR-------SSHKSSHTAMSEPTSTPTKLMAEA-STP 505

  Fly   585 A--NTLTLEELAPSPTPALALVPPAPSSVKSSISKS-----VSVVNVTAARKFQQEHQ-KQRERD 641
            |  .:.||.:..|.|..:.|...|||....||...:     .:|:..|.|...|...| ...:..
Human   506 ALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTI 570

  Fly   642 REQLKERTNSTQGVIRQLSSCLSEAETASCIL----------SPASSLSAS-----EAPDTPDPH 691
            ::||::||...|..||.....|.:.:...|::          .||.|||.|     ||.......
Human   571 KDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 635

  Fly   692 SNTSPPPSLHTRPSV 706
            |.....|.|...|.:
Human   636 SAAVTQPQLGAGPQL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	20/48 (42%)
		PAS	137..>186	CDD:238075	16/48 (33%)
		PAS_11	403..510	CDD:291273	25/107 (23%)
NPAS2	XP_005264010.1	HLH	72..126	CDD:238036	23/72 (32%)
		PAS	149..214	CDD:214512	22/86 (26%)
		PAS_9	159..260	CDD:290162	36/174 (21%)
		PAS_11	314..417	CDD:291273	25/107 (23%)
		PAS	315..415	CDD:238075	25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740