Protein Alignment Met and NPAS1

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_047294837.1
• Gene: NPAS1 / 4861
• HGNCID: 7894
• Length: 650
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 150/688 - (21%)
• Similarity: 233/688 - (33%)
• Gaps: 194/688 - (28%)

  Fly     1 MAAPETGNTGSTGSAGSTGSGSGSG------------SGSGSSSDPANGREARNLAEKQRRDKLN 53
            ||||..|:.|  ||......|.|:.            :.||.........::|| |.:.||.|.|
Human     1 MAAPYPGSGG--GSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRN-AARSRRGKEN 62

  Fly    54 ASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDL 118
            ....|||.::|.....|.:|||.:::|.:...|||:    :.|:......||:..|   .|.|..
Human    63 LEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLR----RFAALGAPPWGLRAAG---PPAGLA 120

  Fly   119 P---NPSL--------HLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQI 172
            |   .|:.        ||...::|.||.....|...|:.:.:|.:|...||..|.::.|.::...
Human   121 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDY 185

  Fly   173 THPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGR 237
            .||.|...:.:||..|            ......|...|.|:|:|:|.|..:..|:|
Human   186 IHPGDHSEVLEQLGLR------------TPTPGPPTPPSVSSSSSSSSSLADTPEIE-------- 230

  Fly   238 QQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGC 302
                                   |.|..:.....:..|.|.||:     ::..|:....||
Human   231 -----------------------ASLTKVPPSSLVQERSFFVRM-----KSTLTKRGLHVK---- 263

  Fly   303 FRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHG------ 361
                        |:.|.::..      ...:.|.|..:.|...|:||.  .:|:..|||
Human   264 ------------ASGYKVIHV------TGRLRAHALGLVALGHTLPPA--PLAELPLHGHMIVFR 308

  Fly   362 ISGNDIVLVAMARVL-REERPPEETEGTVGLTIYRQPEPYQLEY---HTRHLIDGSIIDCDQRI- 421
            :|....:|...:||. ..:..|.|..|.         ..||..:   .||  |..|.:||:..:
Human   309 LSLGLTILACESRVSDHMDLGPSELVGR---------SCYQFVHGQDATR--IRQSHVDCETHLH 362

  Fly   422 --------------GLVAGYMKDEVRNL---------SPFCFMHLDDVRWVIVALRQMYDCNS-- 461
                          .||.|.....:..:         :||....         |.|::.|.:.
Human   363 PPSLPTTPQTRASHSLVPGSPSSGLPTVPPAAPTAPGTPFSIGR---------AARRLSDASGLL 418

  Fly   462 DYGE---SCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQ----------- 512
            |.|:   ..||.|.|.|.|::|.:...:.....|...|..|.|:.:|.:..|.|
Human   419 DKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPAS 483

  Fly   513 -KVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQ-QLERIVLYLIENLQKSVDSAETVGGQGMES 575
             ..:|.........:.|.||:........::||| |.:||        :......||.|.:  :|
Human   484 VACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRI--------KVEPGPRETKGSE--DS 538

  Fly   576 LMDDGYSSPA-------NTLTLEELAPSPTPALALVPP 606
            ..:|..|.||       :.:....|...|.....|.||
Human   539 GDEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPP 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	18/50 (36%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	29/140 (21%)
NPAS1	XP_047294837.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	23/80 (29%)
		PAS	141..198	CDD:214512	14/56 (25%)
		PAS	295..354	CDD:214512	16/69 (23%)