DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and ARNT

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	832	Identity:	175/832 - (21%)
Similarity:	289/832 - (34%)	Gaps:	263/832 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAPE-TGNTGSTGSA---GSTGSG-SGSGS-----------------GSG--------------- 29
            |.|| |.:..|.|.|   |::|.| .|.|:                 |.|
Human     6 ANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSND 70

  Fly    30 -----------SSSDPAN-GREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFA 82
                       ||:|... .||..:..|::||:|:.|.|.||:.|||..:..:|:.||..:||.|
Human    71 KERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 135

  Fly    83 THGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPNPSLHLTD-----TLMQLLDCCFLTLTC 142
            ...::                .|:|||.:::.....|:   .|||     .:::..|.....::|
Human   136 VSHMK----------------SLRGTGNTSTDGSYKPS---FLTDQELKHLILEAADGFLFIVSC 181

  Fly   143 -SGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHN 206
             :|::|.||.||..:|...||:.:|..|....||||.|.||:||
Human   182 ETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL--------------------- 225

  Fly   207 PQQHSTSTSASTSG-SDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRL 270
                |||.:|.|.. .||:...::.|    |:|..                             :
Human   226 ----STSENALTGRILDLKTGTVKKE----GQQSS-----------------------------M 253

  Fly   271 RM---DRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPI-VSQL-IRRSRN 330
            ||   .||.|..|:...|:..:                             |: |::| ..|:|.
Human   254 RMCMGSRRSFICRMRCGSSSVD-----------------------------PVSVNRLSFVRNRC 289

  Fly   331 NNMLAAAAAVAAEAATV---------PPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETE 386
            .|.|.:..........|         ||...::.........|:...|||:.| |:....|..|:
Human   290 RNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGR-LQVTSSPNCTD 353

  Fly   387 GTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEV--RNLSPFCFMHLDDVRWV 449
                ::...||    .|:.:||.|:|.....|.|.....||...|:  :|:..||  |.:|.:.:
Human   354 ----MSNVCQP----TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFC--HPEDQQLL 408

  Fly   450 IVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKV 514
            ..:.:|:...........:|..|:|..::::.|..|...:..|:::...:|.||.:     :...
Human   409 RDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNV-----KNSS 468

  Fly   515 QEMKEKFSTIIK-------AEMPTQSSSPDLPASQAPQQLERIVLYLIE--------NLQKSVDS 564
            ||.:...|..|:       |.:|.:..|..|...|..||.|   |.::.        |..:.|..
Human   469 QEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTE---LDMVPGRDGLASYNHSQVVQP 530

  Fly   565 AETVGGQGMESL----------MDDGYSSPANTLTLEE---LAPSPTPALALV-------PPAPS 609
            ..|.|.:..:.|          .|..:|...:.:..::   ::.|..||...:       ||.|.
Human   531 VTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPR 595

  Fly   610 SVK----SSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETAS 670
            ..:    |.::..|::|..:|:          ..:...|:...:|.|||.....:.......:|.
Human   596 PAENFRNSGLAPPVTIVQPSAS----------AGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQ 650

  Fly   671 CILSPA-----------------SSLSASEAPDTPDPHSNTSPPPSLHTRPS 705
            .:.:.|                 ||.|:...|..|......:..|||..|.|
Human   651 QVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	19/48 (40%)
		PAS	137..>186	CDD:238075	20/49 (41%)
		PAS_11	403..510	CDD:291273	25/108 (23%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		19/90 (21%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		14/39 (36%)
		HLH	91..143	CDD:278439	19/67 (28%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		54/228 (24%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		18/74 (24%)
		PAS	163..269	CDD:279347	38/163 (23%)
		PAS	166..230	CDD:214512	25/88 (28%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		0/3 (0%)
		PAS_11	362..462	CDD:291273	23/101 (23%)
		PAS	362..458	CDD:238075	22/97 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		5/26 (19%)
		Med3	<523..>734	CDD:288447	34/190 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789		10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740