DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and hif1ab

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_001296971.1 Gene:hif1ab / 393202 ZFINID:ZDB-GENE-040426-706 Length:777 Species:Danio rerio


Alignment Length:776 Identity:140/776 - (18%)
Similarity:243/776 - (31%) Gaps:277/776 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            :|....|.:.||.|.:....|||..:|.....:..|||.:::|.....||::.:........:::
Zfish    18 KEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLNSDEKEEKEE 82

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ..|:.                .|....::.|:...:.|:..|.:|.:|.:|.:.:|..|.||.|.
Zfish    83 NELES----------------QLNGFYLKALEGFLMVLSEDGDMVYLSENVSKSMGLTQFDLTGH 131

  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEE 232
            ::.:.:||.|.:.||:.|:                                              
Zfish   132 SIFEFSHPCDHEELREMLV---------------------------------------------- 150

  Fly   233 HRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERV 297
            ||.|.::.:..:.|...:.|..         .|:..|.|      ||.:..|:.:......:.||
Zfish   151 HRTGSKKTKEQNTERSFFLRMK---------CTLTSRGR------TVNIKSATWKVLHCAGHVRV 200

  Fly   298 KIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGI 362
            . :|.....||..      ..|.|:.|:                                     
Zfish   201 H-EGSEASEDSGF------KEPPVTYLV------------------------------------- 221

  Fly   363 SGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLE-------YHTRHLIDGSIIDCDQR 420
                                        |.....|.|..:|       :.:||.:|.....||:|
Zfish   222 ----------------------------LICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDER 258

  Fly   421 IGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY-----------GESC---YRLL 471
            |..:.||..|::.|.|.:.:.|..|               ||:           |::.   ||:|
Zfish   259 ITELMGYEPDDLLNRSVYEYYHALD---------------SDHLTKTHHNLFAKGQATTGQYRML 308

  Fly   472 SRNGRFIYLHTKGFLEVDRGSNKVHSFLCVN-----------------TLLDEEAGRQKVQEMKE 519
            ::.|.|:::.|:..:..:..:::....:|||                 |:.:.:|..::.:|.:|
Zfish   309 AKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEKESEETEE 373

  Fly   520 KFS--TIIKAEMP------TQSSS--------PDLPASQAP------------------QQLERI 550
            |.|  .|:|...|      .:||:        |:.....||                  |.|:.:
Zfish   374 KTSELDILKLFKPESLNCSLESSTLYNKLKEEPEALTVLAPAAGDAIISLDFNNSDSDIQLLKEV 438

  Fly   551 VLY----LIENLQK---------------SVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPS 596
            .||    |..:.:|               ::...||.|.....|...|....|.||.:...|..|
Zfish   439 PLYNDVMLPSSSEKLPLSLSPLTPSDSIPALTKLETGGEDFPFSSASDRVPDPTNTPSTSGLGSS 503

  Fly   597 -PTPAL----ALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVI 656
             |...:    .:.|...|..|..:.:.:..::..|...|..  |...:.|.|.|...........
Zfish   504 GPNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFST--QPMEDLDLEMLAPYIPMDDDFQ 566

  Fly   657 RQLSSCLSEAETASCILSPASSLSASEAPDTPDPHSNTSPPPSLHT---------RPSVLH 708
            .::.|.|....:|:..:|..|||.      .|.|.|..||..|..:         .||.||
Zfish   567 LRIPSPLDPLPSATHSVSAMSSLF------QPLPSSPASPASSTSSTVKQEASSRAPSPLH 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 15/50 (30%)
PAS 137..>186 CDD:238075 15/48 (31%)
PAS_11 401..510 CDD:464214 28/146 (19%)
hif1abNP_001296971.1 bHLH_SF 12..75 CDD:469605 15/56 (27%)
PAS 94..149 CDD:214512 16/54 (30%)
PAS_3 254..339 CDD:430001 21/99 (21%)
HIF-1 543..574 CDD:463274 5/32 (16%)
HIF-1a_CTAD 740..776 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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