Protein Alignment Met and trh

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Alignment Length: 837
• Identity: 167/837 - (19%)
• Similarity: 279/837 - (33%)
• Gaps: 205/837 - (24%)

  Fly     4 PETGNTGS----TGSAG-------------------------STGSGSGSGSGSGSSSDPAN--- 36
            |..|:.||    .||.|                         .||.....|:|..:...|..
  Fly    19 PTPGHPGSHMATMGSLGMPAVPFTHSWMVPTQDLCAMPPYNKMTGHQQPPGAGMHAQQQPLEPGI 83

  Fly    37 ---GREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG----- 93
               .:|....|.:.||.|.|....|||.|:|..|..:.:|||.:::|.....|:|:...|
  Fly    84 LELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPP 148

  Fly    94 --KSASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQL 156
              :.||...|   ||...:..||..||...  |....::|.||...|.:...|:.:.:|.:|...
  Fly   149 WTREASSSSK---LKSAAIRRSPAVDLFEQ--HQGTHILQSLDGFALAVAADGRFLYISETVSIY 208

  Fly   157 LGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGS 221
            ||..|.::.|.::....|..|...:..||            ......|......|:|:.....|:
  Fly   209 LGLSQVEMTGSSIFDYIHQADHSEIADQL------------GLSLTSGGGGGGGSSSSGGGGGGA 261

  Fly   222 DLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARAST 286
            .          ..:......|.||....:....|........|:.......| |.|.||:....|
  Fly   262 G----------GGMASPTSGASDDGSGTHGTNNPDVAASMTQASTSGYKGYD-RSFCVRMKSTLT 315

  Fly   287 RAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQ- 350
            :.            ||..:|.......|.:|....:.....::|.....:..:|......:.||
  Fly   316 KR------------GCHFKSSGYRASDATSNCNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQY 368

  Fly   351 ---HDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLE-----YHTR 407
               |...:|..|.|       :||:|..|    ||              |..:::.     :.||
  Fly   369 TFSHSRKSQPPLLG-------MVALAIAL----PP--------------PSVHEIRLECDMFVTR 408

  Fly   408 HLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGE---SCYR 469
            ...|..:..|:.|:..:..|..:::.|.|.:...|.:|..    .||:.:....:.|:   ..||
  Fly   409 VNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDAN----RLRKSHSDLIEKGQVLTGYYR 469

  Fly   470 LLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQE--MKEKFSTIIKAE---- 528
            |::::|.:.:|.|...:.....:....:.:|||.::........:.:  ..|.....||.|
  Fly   470 LMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEEGLG 534

  Fly   529 MPTQSSSPDLPAS-QAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEE 592
            ....|.||...|| :....|....:.|  |..|:.....:..|:|..:....|  |..|:||:.:
  Fly   535 NDKSSGSPGGDASGEGNSHLSAGDMKL--NSPKTDSEGHSHRGRGRSAAASHG--SSMNSLTMIK 595

  Fly   593 LAPSP---------------TPALALVPPAPSSVKSSISKS------------VSVVNVTAARKF 630
            .:|:|               ||..|..||..|:.:...:|:            :|...:......
  Fly   596 DSPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTM 660

  Fly   631 QQEHQKQRERDREQLKERTNS-TQGVIRQLSSCLSEAETASCILSPASSLSASEAPDTP------ 688
            :|..|:.|.|....:.|:.:| ....::.|...:|:.     :.|||:.:|.: .|:|.
  Fly   661 EQRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKH-----LPSPAAVVSVA-PPNTDFSADSL 719

  Fly   689 ----------DPHSNTS-----------PPPSL----------HTRPSVLHRTLTST 714
                      ||:..:|           ||..:          ..|.||:..|...|
  Fly   720 LKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQT 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	17/50 (34%)
		PAS	137..>186	CDD:238075	11/48 (23%)
		PAS_11	401..510	CDD:464214	22/116 (19%)
trh	NP_001261207.1	bHLH-PAS_trachealess_like	83..152	CDD:381576	19/68 (28%)
		PAS	176..236	CDD:214512	14/59 (24%)
		PAS_3	415..502	CDD:430001	17/90 (19%)