Protein Alignment Met and Bmal2

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_038963872.1
• Gene: Bmal2 / 362464
• RGDID: 620230
• Length: 625
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 147/677 - (21%)
• Similarity: 251/677 - (37%)
• Gaps: 188/677 - (27%)

  Fly    36 NG-REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRR 99
            || |||.:..||:||||:|..|.:|::|:|....::.:|||.::||.|...||.|
  Rat    85 NGIREAHSQTEKRRRDKMNHLIWKLSSMIPPHIPTAHKLDKLSILRRAVQYLRSQ---------- 139

  Fly   100 RKKTGLKGTGMSASPVGDLPNPSL----HLTDTLMQLLDCCFLTLTC-SGQIVLVSTSVEQLLGH 159
                    .||:...:|:...||.    .|:..:::..:...|.:.| .|:|:.||.||.:.|.:
  Rat   140 --------RGMTEFYLGENAKPSFIQDKELSHLILKAAEGFLLVVGCEGGRILFVSKSVSKTLHY 196

  Fly   160 CQSDLYGQNLLQITHPDDQDLLRQQLI--------PRDIETLFYQHQHHQQQGHNPQQHSTSTSA 216
            .|:.|.||||.....|.|...:::||.        |...::.|:     .|...:||.||.|
  Rat   197 DQASLMGQNLFDFLQPKDVAKVKEQLSCDVSLREKPIGTKSEFF-----LQSLASPQVHSHS--- 253

  Fly   217 STSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRL 281
                             .:||.:       .|..:||: ...||....|:.  ::.::||
  Rat   254 -----------------HIGRSR-------VHSGSRRS-FFFRMKSSCTVP--VKEEQRC----- 286

  Fly   282 ARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVA-AEAA 345
             .:.::.:..|.:..:...|..|....::.|        ..:.:...:::..|....|:. .:..
  Rat   287 -SSCSKKKDQRKFHTIHCTGYLRSWPPNVVG--------TEKEMGSGKDSGPLTCLVAMGRLQPY 342

  Fly   346 TVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLI 410
            ||||::..|                       ..||                    .|:.||..:
  Rat   343 TVPPKNGKI-----------------------NVRP--------------------AEFITRFAM 364

  Fly   411 DGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNG 475
            :|..:..|||...:.||:..|:...|.:.:.|.||...:....:.:...........|:...::|
  Rat   365 NGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNLSDKHKAVLQSKEKILTDSYKFRVKDG 429

  Fly   476 RFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPA 540
            .|:.|.:|.|...:..:.|:...:.||||:   .||.:                 |..|.|...:
  Rat   430 SFVTLKSKWFSFTNPWTKKLEYIVSVNTLV---LGRSE-----------------TAVSVPQCRS 474

  Fly   541 SQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVP 605
            ||:.:...|.....:..:     |..|:.|.|  |:..|    .||.:...:.:.|.:|..|
  Rat   475 SQSSEDSFRQPCVSVPGI-----STGTLLGAG--SIGTD----IANEVLSLQRSHSSSPEDA--- 525

  Fly   606 PAPSSV---KSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGV--IRQLSSCLSE 665
             .||.|   |.|::...:.|.|:....|....:                |:|:  .||..|
  Rat   526 -NPSGVVRDKHSVNFGSAPVPVSTGELFALSPE----------------TEGLEAARQHQS---- 569

  Fly   666 AETASC---ILSPASSLSASEAPDTPD 689
            ||.|.|   :||.::.|......|:.|
  Rat   570 AEPAHCHKPLLSDSTQLGFDALCDSDD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	22/50 (44%)
		PAS	137..>186	CDD:238075	18/49 (37%)
		PAS_11	401..510	CDD:464214	25/108 (23%)
Bmal2	XP_038963872.1	bHLH_SF	87..146	CDD:469605	25/76 (33%)
		PAS	171..268	CDD:238075	32/129 (25%)
		PAS_11	357..459	CDD:464214	24/101 (24%)