DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and arntl1b

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_005166673.1	Gene:	arntl1b / 352935	ZFINID:	ZDB-GENE-030408-1	Length:	676	Species:	Danio rerio

Alignment Length:	704	Identity:	156/704 - (22%)
Similarity:	253/704 - (35%)	Gaps:	206/704 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRR 100
            |.|||.:..||:||||:|:.|.|||::||.....||:|||..|||.|...::.
Zfish   128 NAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------ 180

  Fly   101 KKTGLKGTGMSASPVGDLPNPSLHLTD-----TLMQLLDCCFLTLTCS-GQIVLVSTSVEQLLGH 159
                |:|   :|:|..:.......|:|     .:::..|.....:.|. |:|:.||.||.::|.:
Zfish   181 ----LRG---AANPYTEANYKPAFLSDDELKHLILKAADGFLFVVGCDRGKILFVSESVYKILNY 238

  Fly   160 CQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLE 224
            .|:||.||:|....||.|...:::||                                 |.||..
Zfish   239 SQNDLIGQSLFDYLHPKDIAKVKEQL---------------------------------SSSDTA 270

  Fly   225 EEEMETEEHRLGRQQGEADDDEDHPYNRRT---PSPRRMAHLATIDDRLRMDRRCFTVRLA--RA 284
            ..|      ||      .|.....|.  ||   |||.|:...|         ||.|..|:.  |:
Zfish   271 PRE------RL------IDAKTGLPV--RTDIAPSPSRLCSGA---------RRSFFCRMKCNRS 312

  Fly   285 STRAE-----ATRHYERVKIDGCFRRSDSSL-TGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAE 343
            ..:.|     :|  ..:.|.|   |:|..:: :.|...::|.....:.....
Zfish   313 MVKMEDKDFPST--CSKKKAD---RKSFCTIHSTGYLKSWPPTKMGLDEDNE------------- 359

  Fly   344 AATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRH 408
                 |.::..          |...|||:.| |.....|:...|.:      :.:|  .||.:||
Zfish   360 -----PDNEGC----------NLSCLVAIGR-LHPHIVPQPVNGDI------RVKP--TEYVSRH 400

  Fly   409 LIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSR 473
            .|||..:..|||...:..|:..|:...|.:.:.|.||:..:....||:..........||:...:
Zfish   401 AIDGKFVFVDQRATAILAYLPQELLGTSFYEYFHQDDIGHLAECHRQVLQMREKINTHCYKFKIK 465

  Fly   474 NGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLD------EEAGRQKVQEMKEKFSTIIKAEMPTQ 532
            :|.||.|.::.|..::..:.:|...:..||::.      .|.|..::....:...:::.|...:.
Zfish   466 DGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVSGSSVDGAEPGFPQLSASPQSMDSVLTAADGSG 530

  Fly   533 SSSPDLPAS--QAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAP 595
            .:.|.||..  ....::.|::...:..:.:...|:.:..|           |||.|       ..
Zfish   531 KTVPGLPGGTRAGAGKIGRMIAEEVMEIHRIRGSSPSSCG-----------SSPLN-------IS 577

  Fly   596 SPTPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLS 660
            :.||     ||..||              .||||.                    |..|.....|
Zfish   578 NSTP-----PPDTSS--------------PAARKM--------------------SNGGTPDIPS 603

  Fly   661 SCLSEAETA-------SCILSPASSLSASEAPDTPDPHSNTSPPPSLHTRPSVL 707
            :.|...:.:       |.|||..|.:...:..|.|...|.:|...::....|:|
Zfish   604 AGLGSGQDSIGYPYSNSSILSDNSHIGIGDIMDEPGSSSPSSDEAAMAIIMSLL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	25/48 (52%)
		PAS	137..>186	CDD:238075	18/49 (37%)
		PAS_11	403..510	CDD:291273	29/112 (26%)
arntl1b	XP_005166673.1	HLH	130..182	CDD:278439	25/67 (37%)
		PAS	202..309	CDD:279347	39/162 (24%)
		PAS	205..264	CDD:214512	18/58 (31%)
		PAS_11	395..498	CDD:291273	28/102 (27%)
		PAS	397..492	CDD:238075	24/94 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940