DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Met and npas2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_840084.1	Gene:	npas2 / 352934	ZFINID:	ZDB-GENE-030408-3	Length:	845	Species:	Danio rerio

Alignment Length:	714	Identity:	150/714 - (21%)
Similarity:	243/714 - (34%)	Gaps:	194/714 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||.||: ......|::||:.:|:.....|:.|............:
Zfish    44 RASRNKSEKKRRDQFNVLIKELCTML-QGQGHPRKMDKSTILQRTIDFLQKQKEITAQTESCEVR 107

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ...|.:.:|          :...|..:::.||...:.||..|.|:.||.||..|:||..||:..|
Zfish   108 QDWKPSFLS----------NEEFTQLMLEALDGFLIALTTDGNIIYVSDSVSSLIGHLPSDMVDQ 162

  Fly   168 NLLQI----THPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEM 228
            |:|..    .|.|...||                          ..|...|.:||... |...|.
Zfish   163 NILNFLPEREHADVYKLL--------------------------SSHMLLTESSTVDL-LNSNET 200

  Fly   229 ETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRH 293
            ..|                                             |...:||.:...:....
Zfish   201 HVE---------------------------------------------FCCHIARGNIDPKEPPT 220

  Fly   294 YERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAA 358
            ||.||..|.|                       :..||..|::...           :|......
Zfish   221 YEYVKFVGDF-----------------------KFHNNVPLSSCNG-----------YDLAFPRT 251

  Fly   359 LHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGL 423
            |.......:.|||..|:    ..|:..:....:      |....|:.:||.::...:..|.|...
Zfish   252 LQSSIEEQVCLVATVRL----ATPQFLKDLCNV------EDVCDEFTSRHSLEWKFLFLDHRASP 306

  Fly   424 VAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESC-YRLLSRNGRFIYLHTKGFLE 487
            :.||:..||...|.:.:.|:||:..:....:|:..|..  |:|| ||.|::..::|:|.|..::.
Zfish   307 IIGYLPFEVLGTSGYDYYHVDDLELIAQCHKQLMQCGK--GKSCYYRFLTKGQQWIWLQTHYYIT 369

  Fly   488 VDRGSNKVHSFLCVNTLL---DEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLER 549
            ..:.::|....:|.::::   :..|.|::              |...:.||.|:..|....|  .
Zfish   370 YHQWNSKPEFIVCTHSVVSYAEVRAERRR--------------EFGLEESSSDMATSSIKGQ--E 418

  Fly   550 IVLYL---IENLQKSVDSAETVGGQGME-----SLMDDGYSS-----PANTLTLEELAPSP---- 597
            :.|.:   :|..:..::||.:|..|...     :|.|...:|     .|.|.:.:..:..|
Zfish   419 VFLDMCPPLEATRDRINSARSVSSQSSRKSSHTALSDSASNSSVRYTEACTSSRQSASIGPEKSS 483

  Fly   598 -----TPALALVPPAPSSVKSSISKSVS--VVNVTAARKFQQEHQKQRERDREQLKERTNSTQGV 655
                 |....|:....||...|:|.|.|  .....:...|||.......:.:|||:|||...|..
Zfish   484 NRMTHTGTKTLIQRQSSSEPPSLSPSCSQHSAMTQSLYSFQQPQLGVMHQLKEQLEERTRILQAD 548

  Fly   656 IR-------QLSSCLSEAETASCILSPASSLSASEAPDTPDP----HSNTSPPP------SLHT 702
            |:       .:...|..|.....:..|.....|...|....|    ..||.|.|      |.||
Zfish   549 IKTQQQELHDIKEKLQLANLQMLLQQPIQGEFAGSGPQQQGPGRPAQQNTHPKPQHCVSHSSHT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	18/48 (38%)
		PAS	137..>186	CDD:238075	20/52 (38%)
		PAS_11	403..510	CDD:291273	26/110 (24%)
npas2	NP_840084.1	HLH	40..96	CDD:238036	20/52 (38%)
		PAS	119..>203	CDD:307226	29/110 (26%)
		PAS_3	285..388	CDD:330807	26/104 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740