Protein Alignment Met and Ncoa1

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_017449617.1
• Gene: Ncoa1 / 313929
• RGDID: 1309046
• Length: 1443
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 164/789 - (20%)
• Similarity: 264/789 - (33%)
• Gaps: 196/789 - (24%)

  Fly    24 SGSGSGSSSDPAN-------GREARNLA---EKQRRDKLNASIQELATM----VPHAAESSRRLD 74
            ||.|. |||||||       |.....||   ||:||::.|..::|||.:    :......|.:.|
  Rat     2 SGLGD-SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPD 65

  Fly    75 KTAVLRFATHGLRLQYVFGKSASRRRKKT--GLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCF 137
            |..:|:.....::|.    |...:.:..|  .::.:.:|:|..|.:...|  |...|::.||..|
  Rat    66 KCKILKKTVDQIQLM----KRMEQEKSTTDDDVQKSDISSSSQGVIEKES--LGPLLLEALDGFF 124

  Fly   138 LTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQ 202
            ..:.|.|:||.||.:|...||:.|.:|...::..|.|..|.....:.|:|:.:
  Rat   125 FVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSL------------ 177

  Fly   203 QGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATID 267
                           .:|....:|......|....:......||....|:.......:
  Rat   178 ---------------VNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEV------- 220

  Fly   268 DRLRMDRRCFTVRLARASTRAEATRHYERVKIDG--------CFRR---SDSSLTGGAAANYPIV 321
                  .:||||...::            ::.||        |..|   ...::||        |
  Rat   221 ------MQCFTVSQPKS------------IQEDGEDFQSCLICIARRLPRPPAITG--------V 259

  Fly   322 SQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQA--ALHGISGNDIVLVAMARVLREERPPEE 384
            ...:.:......:.:....:..||......|.:.:.  |.....|.:   .:.||.|.:|   ..
  Rat   260 ESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGRE---PSYARQLFQE---VM 318

  Fly   385 TEGTVGLTIYR--QPEPYQLEYHTR------------------HLID----GSIIDCDQRIGLVA 425
            |.||.....||  ..:...|..||:                  |:||    |.....|...|:..
  Rat   319 TRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSI 383

  Fly   426 GYMKDEVR-NLSPFCFMH-------LDDVRWVIVALR----QMYDCNSDYGESCYRLLSRNGRF- 477
            ..:...|. .:||   .|       |......:|:.|    |..|.||  |.|.....|..|.|
  Rat   384 PRINPSVNPGISP---AHGVTRSSTLPPSNNNMVSARANRQQSTDLNS--GSSHSNSSSSQGSFG 443

  Fly   478 -----IYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEK----FSTIIKAEMPTQS 533
                 ..:.:....:...||...:..|.:|....|..|....|.|..:    .....:|.|...|
  Rat   444 CSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNS 508

  Fly   534 SSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPSPT 598
            ..|::|...:|   ..|......|..:|..:......|||....::.....|.:..|.:::...:
  Rat   509 FPPNIPTLSSP---VGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNS 570

  Fly   599 PALALVPPAPSSVKSSISKSVSVVNVTAARKFQQE--------------HQKQRERDREQLKERT 649
            |:...:.||.:..|.: .:..|::|    ...|.:              |...|..|.:   .:.
  Rat   571 PSRLSMQPAKAESKDN-KEIASILN----EMIQSDNSANEGKPLDSGLLHNNDRLSDGD---SKY 627

  Fly   650 NSTQGVIRQLSSCLSEAE------TASC--ILS-PASSLSASEAPD---TPDPHSNTSPPPSLHT 702
            :.|...:.||.:..:|.:      ..||  :|| ..:|.|||..|.   .|..||      ||..
  Rat   628 SQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHS------SLTE 686

  Fly   703 RPSVLHRTL 711
            |..:|||.|
  Rat   687 RHKILHRLL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	14/57 (25%)
		PAS	137..>186	CDD:238075	15/48 (31%)
		PAS_11	401..510	CDD:464214	30/148 (20%)
Ncoa1	XP_017449617.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	16/63 (25%)
		PAS	120..213	CDD:238075	25/119 (21%)
		PAS_11	259..370	CDD:464214	21/116 (18%)
		NCOA_u2	469..591	CDD:465223	24/125 (19%)
		SRC-1	630..709	CDD:462615	23/72 (32%)
		DUF4927	744..821	CDD:465083
		Nuc_rec_co-act	927..972	CDD:462608
		Med15	<977..>1289	CDD:312941
		DUF1518	1152..1208	CDD:462174
		DUF1518	1215..1270	CDD:462174