DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and HIF1A

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_001230013.1 Gene:HIF1A / 3091 HGNCID:4910 Length:850 Species:Homo sapiens


Alignment Length:721 Identity:127/721 - (17%)
Similarity:215/721 - (29%) Gaps:276/721 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 NGR-------EARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG 93
            |||       |....|.:.||.|.:....|||..:|.....|..|||.:|:|.....||::.:. 
Human    34 NGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLL- 97

  Fly    94 KSASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFL--------TLTCSGQIVLVS 150
                                ..||     |.:.|.:...::|.:|        .||..|.::.:|
Human    98 --------------------DAGD-----LDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYIS 137

  Fly   151 TSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTS 215
            .:|.:.:|..|.:|.|.::...|||.|.:.:|:.|                              
Human   138 DNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREML------------------------------ 172

  Fly   216 ASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVR 280
                            .||.|                                            
Human   173 ----------------THRNG-------------------------------------------- 177

  Fly   281 LARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAA 345
            |.:........|.:        |.|...:||.              |.|..|:         ::|
Human   178 LVKKGKEQNTQRSF--------FLRMKCTLTS--------------RGRTMNI---------KSA 211

  Fly   346 TVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPY--QLE----- 403
            |....|   ....:|....|     :.......::||     ...|.:..:|.|:  .:|     
Human   212 TWKVLH---CTGHIHVYDTN-----SNQPQCGYKKPP-----MTCLVLICEPIPHPSNIEIPLDS 263

  Fly   404 --YHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGES 466
              :.:||.:|.....||:||..:.||..:|:...|.:.:.|..|...:......|: ........
Human   264 KTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTG 327

  Fly   467 CYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVN-------------TLLDEEAGRQKVQEMK 518
            .||:|::.|.::::.|:..:..:..:::....:|||             :|...|...:.|:...
Human   328 QYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSD 392

  Fly   519 EKFSTII-KAEMPTQSS-------SPDLPASQAP--------------------QQLERIVLYLI 555
            .|.:.:. |.|....||       .||.....||                    ||||.:.||  
Human   393 MKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLY-- 455

  Fly   556 ENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVS 620
                                 .|....||...|....||.||.|......|..||...::::.|:
Human   456 ---------------------NDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVA 499

  Fly   621 VVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCILSPASSLSASEAP 685
            :               :.|.:.|.|            :||..:.:.:..:...|..|:..:|..|
Human   500 L---------------KLEPNPESL------------ELSFTMPQIQDQTPSPSDGSTRQSSPEP 537

  Fly   686 DTPDPH 691
            ::|..:
Human   538 NSPSEY 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 18/57 (32%)
PAS 137..>186 CDD:238075 15/56 (27%)
PAS_11 401..510 CDD:464214 25/128 (20%)
HIF1ANP_001230013.1 bHLH-PAS_HIF1a_PASD8 37..107 CDD:381570 20/95 (21%)
PAS 117..172 CDD:214512 15/54 (28%)
PAS_3 278..363 CDD:430001 17/85 (20%)
HIF-1 575..605 CDD:463274
HIF-1a_CTAD 813..849 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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