Protein Alignment Met and ahr2

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_571339.1
• Gene: ahr2 / 30517
• ZFINID: ZDB-GENE-990714-16
• Length: 1027
• Species: Danio rerio
• Alignment Length: 675
• Identity: 142/675 - (21%)
• Similarity: 232/675 - (34%)
• Gaps: 209/675 - (30%)

  Fly    29 GSSSDPANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG 93
            |..|:|:          |:.||:||:.:.:|..::|.:.:...||||.:|||.:...|:::..|.
Zfish    28 GVKSNPS----------KRHRDRLNSELDKLTNLLPFSEDVRARLDKLSVLRLSVGYLKVKSFFN 82

  Fly    94 KSASRRRKKTG-----------LKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIV 147
            .:.    ||||           ..|.|.:||   .|...:....:.|:|.|:...|.:|..|.:.
Zfish    83 ATI----KKTGGNGWLNDRSGTFGGNGQTAS---SLDGVNFSEGELLLQALNGFVLVVTAEGYVF 140

  Fly   148 LVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGH---NPQQ 209
            ..|.:::..||..|||:...::.::.|.||:.:.|:||                   |   ||..
Zfish   141 YSSPTIQDYLGFHQSDVVHHSVFELIHTDDRAMFRRQL-------------------HFALNPSS 186

  Fly   210 HSTSTS-ASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMD 273
            .|...| |..|.||:..:.:.                    ||.:...|...:.|
Zfish   187 DSADGSEAMQSSSDITRDMVN--------------------YNPQHIPPENSSFL---------- 221

  Fly   274 RRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAA 338
            .|.|..|                      ||....:.:|..|.|:   ...::.....|.||...
Zfish   222 ERSFCCR----------------------FRCLLDNSSGFLALNF---QGRLKYLHGQNKLAEDG 261

  Fly   339 AVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLE 403
            .:|      .||                :.|..:|..|   :||...|          .....|.
Zfish   262 TLA------HPQ----------------LALFIIATPL---QPPSILE----------IRSKTLL 291

  Fly   404 YHTRHLIDGSIIDCDQRIGLVAGYMKDEV-RNLSPFCFMHLDDVRWVIVALRQMYDCNSDY---- 463
            :.|:|.:|.:.:..|.|..:|.||.:.|: ...|.:.|:|..|:         || |..::
Zfish   292 FQTKHKLDFTPMGIDTRGKVVLGYTEIELCMRGSGYQFIHAADM---------MY-CADNHIRMI 346

  Fly   464 --GES---CYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMK----- 518
              |||   .:||||:.|.:|::.....|....|  :....:.....|..|.|.:.:::.|
Zfish   347 KTGESGLTVFRLLSKGGTWIWVQANARLVYKAG--RPDFIIARQRALTNEEGEEHLRQRKLQLPF 409

  Fly   519 ----------EKFSTIIKAEMPTQSSSPDL--PASQAPQQL------ERIVLYLIENLQKSVDSA 565
                      |...|:..||:..||....:  |.|..|..|      :...||...|...|..:.
Zfish   410 NCATGEGVLYEVGPTLDVAEIQNQSKGQKMLNPPSLDPDSLLGSMLKQDHSLYSQNNDPNSQFTI 474

  Fly   566 ETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVV----NVTA 626
            :...|.....|     :.|.|  |.:...|:..|.:    ...:.||..:.....::    |..:
Zfish   475 DKAFGDSHALL-----NVPGN--TWQPSTPNTVPGI----KEEAVVKDMLETLQQIIEVGNNCNS 528

  Fly   627 ARKFQQEHQKQRERDREQLKERTNS 651
            ...|        ..||.:|||..|:
Zfish   529 LEDF--------NLDRMELKEWENT 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	15/50 (30%)
		PAS	137..>186	CDD:238075	14/48 (29%)
		PAS_11	401..510	CDD:464214	30/118 (25%)
ahr2	NP_571339.1	bHLH-PAS_AhR_like	27..85	CDD:381539	19/66 (29%)
		PAS	120..183	CDD:214512	19/81 (23%)
		PAS_3	312..386	CDD:430001	22/85 (26%)
		Med15	<600..>832	CDD:312941