DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and clocka

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_571032.2	Gene:	clocka / 30140	ZFINID:	ZDB-GENE-990630-14	Length:	892	Species:	Danio rerio

Alignment Length:	803	Identity:	163/803 - (20%)
Similarity:	265/803 - (33%)	Gaps:	267/803 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TGSAGSTGSGSGSGSGSGSSSDPANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKT 76
            |.|.....|....|.......|.|. |.:||.:||:|||:.|..|:||.||:|   .::|::||:
Zfish     2 TSSIDRDDSSIFDGLMEEDEKDKAK-RVSRNRSEKKRRDQFNVLIKELGTMLP---GNTRKMDKS 62

  Fly    77 AVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPNPSL---HLTDTLMQLLDCCFL 138
            .:|:             ||....||...:.....|:....|...|.|   ..|..:::.||..||
Zfish    63 TILQ-------------KSIDFLRKHKEIAAQSESSEIRQDWKPPFLSNEEFTQLMLEALDGFFL 114

  Fly   139 TLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQ 203
            .:...|.|:.||.||..||.|..|||..||||             ..:|               .
Zfish   115 AIMTDGNIIYVSESVTSLLEHLPSDLVDQNLL-------------NFLP---------------L 151

  Fly   204 GHNPQQHSTSTSASTSGSDLEEEEMETEE------HRLGRQQGEADDDEDHPYN----------- 251
            |.:.:.:...::....|..|..:.::|:.      |.|   :|..|..|...|.
Zfish   152 GEHSEVYKALSTHMLEGETLTPDYLKTKNQLEFCCHML---RGTIDPKEPPVYEYVKFIGNFKSL 213

  Fly   252 RRTPSPRRMAHLATIDDRLR---MDRRCF--TVRLARASTRAEATRHYERVKIDGCFRRSDSSLT 311
            ...|:..|......|...||   .||.||  |||||:
Zfish   214 NTVPNSTRNGFEGVIQRSLRHAFEDRVCFIATVRLAK---------------------------- 250

  Fly   312 GGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVL 376
                      .|.|:                |..||
Zfish   251 ----------PQFIK----------------EMCTV----------------------------- 260

  Fly   377 REERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFM 441
              |.|.|                   |:.:||.::...:..|.|...:.||:..||...|.:.:.
Zfish   261 --EEPNE-------------------EFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYY 304

  Fly   442 HLDDVRWVIVALRQMYDCNSDY--GESC-YRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNT 503
            |:||:.    .|.:.::....|  |:|| ||.|::..::|:|.|..::...:.:::....:|.:|
Zfish   305 HVDDLE----TLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHT 365

  Fly   504 LLD--EEAGRQKVQEMKEKFSTIIKAEMPTQS-SSPDLPASQAPQQLERIVLYLIENLQKSVDSA 565
            ::.  |....|:.:...|:....|.|:....| |...|..|...:.|||.            |.:
Zfish   366 VVSYAEVRAEQRRELGIEESPPEISADKSQDSGSESQLNTSSLKEALERF------------DHS 418

  Fly   566 ETVGGQGMESLMDDGY---SSPANTLTLEELAPSPTP---------------------------- 599
            .|.......|.....:   |.|.:|.|..:...|..|
Zfish   419 RTPSASSRSSRKSSSHTAVSDPTSTQTKLQTDRSTPPRQSVSAIEMTSQRRSSISSQSMSSQTTG 483

  Fly   600 -----ALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQR--------ERDREQLKERTNS 651
                 :|...|..|.::::::...:.......|.:..:|..:||        :|.:|:|::..:.
Zfish   484 QTMGTSLVSQPQQPQTLQATVQPVLQFSTQMDAMQHLKEQLEQRTRMIEANIQRQQEELRQIQDE 548

  Fly   652 TQGVIRQ--------------LSSC----LSEAETASCI-----LSPASSLSAS-EAPDTPDPHS 692
            .|.|..|              |||.    .|..:||..:     :.|.::|.:| ::..:...|:
Zfish   549 LQRVQGQGLQMFLQPSGGGLNLSSVQLTQSSSVQTAGTLSMQGAVVPTATLQSSLQSTHSSTQHT 613

  Fly   693 NTSPPPSLHTRPSVLHRTLTSTL 715
            .|..|.....:...|.|..|:.|
Zfish   614 VTQHPQQTAVQQQNLLRDQTTNL 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	19/48 (40%)
		PAS	137..>186	CDD:238075	18/48 (38%)
		PAS_11	403..510	CDD:291273	27/111 (24%)
clocka	NP_571032.2	HLH	23..77	CDD:238036	25/70 (36%)
		PAS	100..>169	CDD:279347	23/96 (24%)
		PAS	109..207	CDD:238075	31/128 (24%)
		PAS_11	265..368	CDD:291273	27/125 (22%)
		PAS	266..364	CDD:238075	25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740