Protein Alignment Met and sim1a

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_835740.2
• Gene: sim1a / 260351
• ZFINID: ZDB-GENE-020829-1
• Length: 745
• Species: Danio rerio
• Alignment Length: 812
• Identity: 145/812 - (17%)
• Similarity: 249/812 - (30%)
• Gaps: 307/812 - (37%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVF----GKSASR 98
            :|....|.:.||:|.|:...|||.::|..:..:.:|||.:::|..|..|:::.||    |:|...
Zfish     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESWGH 66

  Fly    99 RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSD 163
            ..:.|.|:..|.             .|...|:|.||.....:...|:|:.:|.:....||..|.:
Zfish    67 VSRTTSLENVGR-------------ELGSHLLQTLDGFIFVVAPDGKILYISETASVHLGLSQVE 118

  Fly   164 LYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQ-HHQQQGHNPQQHSTSTSASTSGSDLEEEE 227
            |.|.::.:..||.|.|         ::..:...|| :|....|                   |.|
Zfish   119 LTGNSIYEYIHPADHD---------EMTAVLTAHQPYHSHFVH-------------------EYE 155

  Fly   228 METEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEA-- 290
            ||                                             |.|.:|:.....:..|
Zfish   156 ME---------------------------------------------RSFFLRMKCVLAKRNAGL 175

  Fly   291 ---------------TRHY--ERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAA 338
                           .|.|  :....|||::.                                .
Zfish   176 TCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQN--------------------------------V 208

  Fly   339 AVAAEAATVPPQHDAIAQAALHGISGNDIVLVA---MARVLREERPPEETEGTVGLTIYRQPEPY 400
            .:.|...::||  .|:.:..||   .|..:..|   |..:..:.|..|       ||.|   ||.
Zfish   209 GLVAVGHSLPP--SAVTEIKLH---SNMFMFRASLDMKLIFLDSRVAE-------LTGY---EPQ 258

  Fly   401 QL----EYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNS 461
            .|    .||..|..|...:.|...:.||.|.:..:.
Zfish   259 DLIEKTLYHHVHSCDTFHLRCAHHLLLVKGQVTTKY----------------------------- 294

  Fly   462 DYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTL------------LDEEA----- 509
                  ||.|::.|.::::.:...:..:..|::.|..:.||.:            ||:.|
Zfish   295 ------YRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQAASTKPS 353

  Fly   510 ----------------GRQKVQEMKEKFSTIIKAE---MPTQSSSPD---------LPASQAPQQ 546
                            |:.:|...|.|......::   .||..|..|         |..|.:||.
Zfish   354 FTYNSPSNPVTENRRVGKSRVSRTKTKTRLSPYSQYPGFPTDRSESDQDSPWGGSPLTDSASPQL 418

  Fly   547 LE-----------------RIVLYLIENLQKSVDSAETVGGQGMESL------------------ 576
            ||                 |.:.|.:...:....|.|.......||.
Zfish   419 LEQCEGIESSCVYRQFSDPRSLCYGLPLTEDHHTSNELYSHPHSESCERGCCKAGRYFLGTPQPG 483

  Fly   577 MDDGYSSPANTLTLEELAPSPTPALALVPPAPSSV-----------KSSISKSVSVVNVTAARKF 630
            .:..:.:..:.|.|.:.:|....:...|.|..:|:           .|::|.........:..:|
Zfish   484 REAWWGAARSVLPLPKSSPENGDSFEGVMPHIASIHSLQVRGHWDEDSAVSSPDGGSASDSGDRF 548

  Fly   631 QQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCI-LSPASSLSAS-EAPDTPD---- 689
            :.:..:...::..:::....:||.:|::..|.|...:..:.: |.|.:||:.| .:.|.|.
Zfish   549 RADQCRSSPQEPSKIETLIRATQQMIKEEESRLQLRKLPTDVPLEPTNSLAKSFHSTDFPQSAMQ 613

  Fly   690 ------PHSNTSPPPSLHTRPSVLHRTLTSTL 715
                  |....||.||    |..|.| |:|.|
Zfish   614 SVVCRGPAQVISPAPS----PVPLSR-LSSPL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	16/50 (32%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	20/145 (14%)
sim1a	NP_835740.2	bHLH-PAS_SIM1	1..71	CDD:381581	20/68 (29%)
		PAS	88..>158	CDD:238075	22/142 (15%)
		PAS_3	243..329	CDD:430001	22/130 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..413		9/62 (15%)
		SIM_C	358..647	CDD:461963	52/288 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		4/18 (22%)