DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and Arnt2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_036913.3	Gene:	Arnt2 / 25243	RGDID:	2154	Length:	712	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	162/757 - (21%)
Similarity:	272/757 - (35%)	Gaps:	199/757 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAPETGNTGSTGSAGSTGSGSGSG------SGSGSSSDPANGREARNLAEKQRRDKLNASIQEL 59
            |||  ||.....|:..:.|....||      .|.|.|.   ..||..:..|::||:|:...|.||
  Rat    27 MAA--TGQVRMAGAMPARGGKRRSGMDFDDEDGEGPSK---FSRENHSEIERRRRNKMTQYITEL 86

  Fly    60 ATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVGDLPN--PS 122
            :.|||..:..:|:.||..:||.|...::                .::|||..::.....|:  ..
  Rat    87 SDMVPTCSALARKPDKLTILRMAVSHMK----------------SMRGTGNKSTDGAYKPSFLTE 135

  Fly   123 LHLTDTLMQLLD-CCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLI 186
            ..|...:::..| ..|:....:|:::.||.||..:|...||:.:|..|.:..||||.:.||:||
  Rat   136 QELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQL- 199

  Fly   187 PRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSG-SDLEEEEMETEEHRLGRQQGEADDDEDHPY 250
                                    .||.::.|.. .||:...::.|    |:|..
  Rat   200 ------------------------CTSENSMTGRILDLKTGTVKKE----GQQSS---------- 226

  Fly   251 NRRTPSPRRMAHLATIDDRLRM---DRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTG 312
                               :||   .||.|..|:.                   |         |
  Rat   227 -------------------MRMCMGSRRSFICRMR-------------------C---------G 244

  Fly   313 GAAANY-PIVSQLIRRSRNNNMLAAAAAVAAEAATV---------PPQHDAIAQAALHGISGNDI 367
            .|..:: |:......|.|..|.|.......|:.|.|         ||...:|.:.......|:..
  Rat   245 NAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMSIPEEDADVGQGSKY 309

  Fly   368 VLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEV 432
            .|||:.|:       :.|...|.:.:.....|  .|:.:||..||.|...|.|...|.||...::
  Rat   310 CLVAIGRL-------QVTSSPVCMDMSGMSVP--TEFLSRHNSDGIITFVDPRCISVIGYQPQDL 365

  Fly   433 --RNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKV 495
              :::..||  |.:|...:..:.:|:...........||..::|..::.:.|..|...:..|:::
  Rat   366 LGKDILEFC--HPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEI 428

  Fly   496 HSFLCVNTLLDEEAGRQKVQEMKEK--FSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENL 558
            ...:|.||.:.:...:|...|:.::  .|:...:::|.    |:||..             :...
  Rat   429 EYVICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPV----PNLPTG-------------VHEA 476

  Fly   559 QKSVDSAETVGGQGME---SLMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVS 620
            .|.|:.|:.:..|..:   :.|..|.|:....:.....|.......:...|.|:. .|..:.|.|
  Rat   477 GKPVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAG-HSGKAFSSS 540

  Fly   621 VVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETA------------SCIL 673
            ||:|......|.                ::||...|.|:|..|::.:.|            |...
  Rat   541 VVHVPGVNDIQS----------------SSSTGQNISQISRQLNQGQVAWTGSRPPFPGQPSKTQ 589

  Fly   674 SPASSLSASEA-PDTPDPHSNTSPP----PSLHTRPSVLHRT 710
            |.|..:.:|.. |..|..:|..|.|    ||.:..||:.:||
  Rat   590 SSAFGIGSSHPYPADPSSYSPLSSPAASSPSGNAYPSLANRT 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	18/48 (38%)
		PAS	137..>186	CDD:238075	18/48 (38%)
		PAS_11	403..510	CDD:291273	25/108 (23%)
Arnt2	NP_036913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		10/41 (24%)
		bHLH-PAS_ARNT	62..124	CDD:381517	21/80 (26%)
		PAS	137..243	CDD:395786	35/182 (19%)
		PAS_11	336..436	CDD:405306	23/101 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..712		16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740