DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and Arnt

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_036912.3	Gene:	Arnt / 25242	RGDID:	2153	Length:	809	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	156/766 - (20%)
Similarity:	268/766 - (34%)	Gaps:	215/766 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SSSDPAN-GREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG 93
            ||:|... .||..:..|::||:|:.|.|.||:.|||..:..:|:.||..:||.|...::
  Rat    82 SSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK------ 140

  Fly    94 KSASRRRKKTGLKGTGMSASPVGDLPNPSLHLTD-----TLMQLLDCCFLTLTC-SGQIVLVSTS 152
                      .|:|||.:::.....|:   .|||     .:::..|.....::| :|::|.||.|
  Rat   141 ----------SLRGTGNTSTDGSYKPS---FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDS 192

  Fly   153 VEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSAS 217
            |..:|...||:.:|..|....||||.|.||:||                         |||.:|.
  Rat   193 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL-------------------------STSENAL 232

  Fly   218 T-------SGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRR 275
            |       :|:..:|.:..:....:|              :||:...|.....:::|. :.|:|.
  Rat   233 TGRILDLKTGTVKKEGQQSSMRMCMG--------------SRRSFICRMRCGTSSVDP-VSMNRL 282

  Fly   276 CFTVRLAR--ASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAA 338
            .|.....|  ..:..|...|:..|...|..:
  Rat   283 SFLRNRCRNGLGSVKEGEPHFVVVHCTGYIK---------------------------------- 313

  Fly   339 AVAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLE 403
            |......::|.......|       |:...|||:.| |:....|..|:    ::...||    .|
  Rat   314 AWPPAGVSLPDDDPEAGQ-------GSKFCLVAIGR-LQVTSSPNCTD----MSNICQP----TE 362

  Fly   404 YHTRHLIDGSIIDCDQRIGLVAGYMKDEV--RNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGES 466
            :.:||.|:|.....|.|.....||...|:  :|:..||  |.:|.:.:..:.:|:..........
  Rat   363 FISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFC--HPEDQQLLRDSFQQVVKLKGQVLSV 425

  Fly   467 CYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQK------VQEMKEKFSTII 525
            .:|..::|..::::.|..|...:..|:::...:|.||.:...:...:      :|..:...:|.:
  Rat   426 MFRFRAKNREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRSQLGPTTNL 490

  Fly   526 KAEMPT-------------QSSSPDLPASQAPQQLERIVLYLI---------ENLQKSVDSAETV 568
            ..||.|             |.........|..||.::..|.::         .:.|.||....|.
  Rat   491 SLEMGTGQLASRQQQQQQQQQQQQQQQQQQQQQQQQQTELDMVPGRDGLASYSHSQVSVQPVATA 555

  Fly   569 GGQ---------------------------------GMES--------LMDDGYSSPANTLTLEE 592
            |.:                                 |:.|        |...|.|.|.|....|.
  Rat   556 GSEHSKPLEKSEGLFVQDRDPRFSEIYPNISADQSKGLSSSTVPATQQLFSQGSSFPPNPRPAEN 620

  Fly   593 LAPSP-TPALALVPPAPSS--VKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQG 654
            ...|. ||.:.:|.|:.|:  :.:.||:..::...:|.............:...|...:|.|:|.
  Rat   621 FRNSGLTPPVTIVQPSSSAGQILAQISRHSNLTQGSAPTWTSSTRPGFSAQLPTQATAKTRSSQF 685

  Fly   655 VIRQLSSCLSEAETASCILSPASSLSASEAPDTPDPHSNTSPPPSLHTRPS 705
            .:....:              :||.||...|..|....:|:..|:|..|.|
  Rat   686 GVNNFQT--------------SSSFSAMSLPGAPTASPSTAAYPTLPNRGS 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	19/48 (40%)
		PAS	137..>186	CDD:238075	20/49 (41%)
		PAS_11	403..510	CDD:291273	24/108 (22%)
Arnt	NP_036912.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..95		5/12 (42%)
		bHLH-PAS_ARNT	86..150	CDD:381517	23/79 (29%)
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:P53762	88..128		14/39 (36%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		50/209 (24%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		18/74 (24%)
		PAS	166..230	CDD:214512	25/88 (28%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		0/3 (0%)
		PAS_3	373..461	CDD:369881	17/89 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..487		1/21 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..575		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..685		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..735		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740