DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Met and Npas2

DIOPT Version :9

Sequence 1:NP_001285132.1 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_032745.2 Gene:Npas2 / 18143 MGIID:109232 Length:816 Species:Mus musculus


Alignment Length:756 Identity:160/756 - (21%)
Similarity:261/756 - (34%) Gaps:249/756 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||::|:|   .::|::|||.||                    .|.
Mouse    11 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVL--------------------EKV 52

  Fly   103 TGL--KGTGMSA-SPVGDLP---NPSL----HLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLL 157
            .|.  |...:|| :.:.|:.   .||.    ..|..:::.||...:.:|..|.|:.||.|:..||
Mouse    53 IGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTDGSIIYVSDSITPLL 117

  Fly   158 GHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQ-----QGHNPQQHSTSTSAS 217
            ||..:|:..||||.                      |...|.|.:     ..|.....|.|....
Mouse   118 GHLPADVMDQNLLN----------------------FLPEQEHSEVYKILSSHMLVTDSPSPEFL 160

  Fly   218 TSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLA 282
            .|.:|||                                                    |...|.
Mouse   161 KSDNDLE----------------------------------------------------FYCHLL 173

  Fly   283 RASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATV 347
            |.|...:....||.:|..|.|                       ||.||               |
Mouse   174 RGSLNPKEFPTYEYIKFVGNF-----------------------RSYNN---------------V 200

  Fly   348 PPQ----HDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRH 408
            |..    .|.......|...|.|:..:|..|:   ..|....|..|.      .||.: |:.:||
Mouse   201 PSPSCNGFDNTLSRPCHVPLGKDVCFIATVRL---ATPQFLKEMCVA------DEPLE-EFTSRH 255

  Fly   409 LIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGES-CYRLLS 472
            .::...:..|.|...:.||:..||...|.:.:.|:||:.  ::|....:......|:| |||.|:
Mouse   256 SLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLE--LLARCHQHLMQFGKGKSCCYRFLT 318

  Fly   473 RNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGR-QKVQEM---------------KEKF 521
            :..::|:|.|..::...:.::|....:|.::::.....| ::.||:               |||.
Mouse   319 KGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPTEAMHPSAVKEKD 383

  Fly   522 STIIKAEMPTQSSSPD-----LPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGY 581
            |::   |.|...::.|     ||:|.:|....|          .|..|:.|.        |.:..
Mouse   384 SSL---EPPQPFNALDMGASGLPSSPSPSASSR----------SSHKSSHTA--------MSEPT 427

  Fly   582 SSPANTLTLEELAPSPTPA-------------LALVPPA-PSSVKSSISKSVSVVNV-------- 624
            |:|...:........|.||             .|.:|.| .||....::|.:.:.::        
Mouse   428 STPTKLMAENSTTALPRPATLPQELPVQGLSQAATMPTALHSSASCDLTKQLLLQSLPQTGLQSP 492

  Fly   625 -TAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASCIL----------SPASS 678
             ....:|..:. ...:..::||::||...|..||.....|.:.:...|::          .||.|
Mouse   493 PAPVTQFSAQF-SMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVS 556

  Fly   679 LSASEAPDTPDPHSNTSPPPSLHTRPSVLHRT-----LTST 714
            ||.| :...|.........|:..::|.::..|     :|||
Mouse   557 LSFS-STQRPAAQQQLQQRPAAPSQPQLVVNTPLQGQITST 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_001285132.1 HLH 38..87 CDD:238036 20/48 (42%)
PAS 137..>186 CDD:238075 15/48 (31%)
PAS_11 403..510 CDD:291273 25/107 (23%)
Npas2NP_032745.2 bHLH-PAS_NPAS2_PASD4 1..77 CDD:381580 26/88 (30%)
Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269|PubMed:23831463 1..61 23/72 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 5/9 (56%)
PAS 84..195 CDD:366402 37/207 (18%)
PAS_11 249..352 CDD:373151 25/105 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..431 17/87 (20%)
omega_3_PfaA <440..>740 CDD:274311 32/159 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..639
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..705
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..816
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834647
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

Return to query results.
Submit another query.