Protein Alignment Met and Npas1

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_032744.1
• Gene: Npas1 / 18142
• MGIID: 109205
• Length: 594
• Species: Mus musculus
• Alignment Length: 680
• Identity: 145/680 - (21%)
• Similarity: 231/680 - (33%)
• Gaps: 201/680 - (29%)

  Fly     1 MAAPETGNTGSTGSAGSTGSGSGSGSG--------------SGSSSDPANGREARNLAEKQRRDK 51
            ||.|..    .:|..|....|.|.|:|              .|.........::|| |.:.||.|
Mouse     1 MATPYP----RSGGRGEVKCGGGRGAGVPWDFLPGLMVKAPPGPCLQAQRKEKSRN-AARWRRGK 60

  Fly    52 LNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKKTGLKGTGMSASPVG 116
            .|....|||.::|.....|.:|||.:::|.:...|||:    :.|:......||:..|   .|.|
Mouse    61 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLR----RFAALGAPPWGLRAVG---PPAG 118

  Fly   117 DLPNP-----------SLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLL 170
            ..|..           ..||...::|.||.....|...|:.:.:|.:|...||..|.:|.|.::.
Mouse   119 LAPGRRGPVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVF 183

  Fly   171 QITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRL 235
            ...||.|...:.:||..|....            ..|...|.|:|:|:|.|.|    ::|.|.
Mouse   184 DYIHPGDHSEVLEQLGLRAASI------------GPPTPPSVSSSSSSSSSSL----VDTPEI-- 230

  Fly   236 GRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKID 300
                 ||...|..|                   ..|...|.|.||:     ::..|:....||
Mouse   231 -----EASPTEASP-------------------AFRAQERSFFVRM-----KSTLTKRGLNVK-- 264

  Fly   301 GCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQAALHGISGN 365
                          |:.|.::..      ...:.|.|..:.|...|:||.  .:|:..|||
Mouse   265 --------------ASGYKVIHV------TGRLRARALGLVALGHTLPPA--PLAELPLHG---- 303

  Fly   366 DIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKD 430
            .:::..:               ::|||                     |:.|:.|:.........
Mouse   304 HMIVFRL---------------SLGLT---------------------ILACESRVSDHMDMGPS 332

  Fly   431 EVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGE---SCYRLLSRNGRFIYLHTKGFLEVDRGS 492
            |:...|.:.|:|..|.    ..:||.:....|.|:   ..||.|.|.|.|::|.:...:..:..|
Mouse   333 ELVGRSCYQFVHGQDA----TRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKS 393

  Fly   493 NKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAE------MPTQSSSP-----DLPASQ---- 542
            ...|..|.|:.:|....|.|...:..:..:.:.:.|      .||:...|     .:||.|
Mouse   394 TGEHHVLWVSHVLSNAEGSQTPLDAFQLPAIVSQEEPSRPGPEPTEEEPPVDGKQAVPADQDKDK 458

  Fly   543 APQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSP---------ANTLTLEELAP--- 595
            .||...:.:  .:|...|....:|..|    |..:.|..:.|         |..|..:.:.|
Mouse   459 DPQARGKRI--KVEASPKEARGSEDSG----EEELSDPPAPPRPEFTSVIRAGALKHDPVLPWGL 517

  Fly   596 ----SPTPAL---ALVPP------APSSVK 612
                .|:|||   ..:||      .|.:::
Mouse   518 TTPGDPSPALLHAGFLPPVVRGLCTPGTIR 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	18/50 (36%)
		PAS	137..>186	CDD:238075	13/48 (27%)
		PAS_11	401..510	CDD:464214	24/111 (22%)
Npas1	NP_032744.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	23/80 (29%)
		PAS	141..198	CDD:214512	15/56 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..237		12/41 (29%)
		PAS_3	316..387	CDD:430001	19/74 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..498		16/76 (21%)