Protein Alignment Met and Ncoa3

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_032705.2
• Gene: Ncoa3 / 17979
• MGIID: 1276535
• Length: 1403
• Species: Mus musculus
• Alignment Length: 860
• Identity: 176/860 - (20%)
• Similarity: 286/860 - (33%)
• Gaps: 274/860 - (31%)

  Fly    26 SGSGSSS-DP-------------ANGREARNLAEKQRRDKLNASIQELATMVPHAAESSR----- 71
            ||.|.|| ||             |.|:......||.||::.:..|:|||.::  :|..|.
Mouse     2 SGLGESSLDPLAAESRKRKLPCDAPGQGLVYSGEKWRREQESKYIEELAELI--SANLSDIDNFN 64

  Fly    72 -RLDKTAVLRFATHGLRLQYVFGKSASRRR--KKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLL 133
             :.||.|:|:.....:|.....||:.|...  :|..:..||.     |.:...|  |...|:|.|
Mouse    65 VKPDKCAILKETVRQIRQIKEQGKTISSDDDVQKADVSSTGQ-----GVIDKDS--LGPLLLQAL 122

  Fly   134 DCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDD-QDLLRQQLIPRD-IETLFYQ 196
            |.....:...|.||.||.:|.|.|.:.|.||...::..|.|..| :|.|:.  :|:. :..:.:.
Mouse   123 DGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYSILHEQDRKDFLKH--LPKSTVNGVSWT 185

  Fly   197 HQHHQQQGHN------PQQHSTSTSASTSGSDLEEEEMETEE-HRLGRQQGEADDDEDHP----- 249
            :::.:|:.|.      .:.|......:.|..  ..:..||.: ..|.:.:...::.||..
Mouse   186 NENQRQKSHTFNCRMLMKTHDILEDVNASPE--TRQRYETMQCFALSQPRAMLEEGEDLQCCMIC 248

  Fly   250 YNRRTPSP---------------RRMAHLATIDDRLRMD-------RRC----FTVRLARASTRA 288
            ..||..:|               .::.::.|...|..|.       |||    |::...::.::
Mouse   249 VARRVTAPFPSSPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQ- 312

  Fly   289 EATRHYERVKIDG-----CFRRSDSSLTGGAAANYPIVSQLIRRSRNNNM--LAAAAAVAAEAAT 346
              .|||:...:.|     .:|   .||..|...:....|:|.|....|:.  ..:...:..|...
Mouse   313 --KRHYQEAYVHGHAETPVYR---FSLADGTIVSAQTKSKLFRNPVTNDRHGFISTHFLQREQNG 372

  Fly   347 VPPQHDAIAQ-----AALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHT 406
            ..|..:...|     ||..|:|                ..|.:....:|...|..|:|
Mouse   373 YRPNPNPAGQGIRPPAAGCGVS----------------MSPNQNVQMMGSRTYGVPDP------- 414

  Fly   407 RHLIDGSIIDCDQRIGLVAGY---MKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCY 468
                        ...|.:.|.   ....|.:|:|                .|.....|.|..|.|
Mouse   415 ------------SNTGQMGGARYGASSSVASLTP----------------GQSLQSPSSYQNSSY 451

  Fly   469 RL-----------LSRNGRFIYLHTKGFLEVDRGSNKV-----------------------HSFL 499
            .|           |..|.:.|.:..:     :|||.|:                       |||
Mouse   452 GLSMSSPPHGSPGLGPNQQNIMISPR-----NRGSPKMASHQFSPAAGAHSPMGPSGNTGSHSF- 510

  Fly   500 CVNTLLDEEAGRQKVQEMKEKFSTIIKAEM----PTQSSSPDLPASQAPQQL------ERIVLYL 554
                   ..:....:|.:.|...|.:.:.:    |...:||::..|| |.::      ..:.||.
Mouse   511 -------SSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNISQ-PSKVSGQDSKSPLGLYC 567

  Fly   555 IEN-LQKSV------------DSAETVG-----------GQGMESLM--------DDGYSSPANT 587
            .:| ::.||            :|.|:.|           .:|.:.|:        |.|:||
Mouse   568 EQNPVESSVCQSNSRDHPSEKESKESSGEVSETPRGPLESKGHKKLLQLLTCSSDDRGHSS---- 628

  Fly   588 LTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNST 652
            ||...|.|:...:...| .:||.|.||.|.:||..:.......|::|     |...:|.:..||.
Mouse   629 LTNSPLDPNCKDSSVSV-TSPSGVSSSTSGTVSSTSNVHGSLLQEKH-----RILHKLLQNGNSP 687

  Fly   653 QGVIRQLSSCLSE--AETASC--------ILSP-----------------ASSLSASEAPDTPDP 690
            ..|.:..:....:  :.||||        .|||                 .|.:.|.|.....|.
Mouse   688 AEVAKITAEATGKDTSSTASCGEGTTRQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADS 752

  Fly   691 HSNTSPPPSLHTRPS 705
            ..:.....|..|.||
Mouse   753 GDSKLSQCSCSTNPS 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	15/56 (27%)
		PAS	137..>186	CDD:238075	16/49 (33%)
		PAS_11	401..510	CDD:464214	21/145 (14%)
Ncoa3	NP_032705.2	bHLH_SF	33..102	CDD:469605	19/70 (27%)
		PAS	117..172	CDD:214512	19/54 (35%)
		PAS_11	262..372	CDD:464214	20/115 (17%)
		NCOA_u2	451..564	CDD:465223	21/126 (17%)
		SRC-1	608..696	CDD:462615	26/97 (27%)
		DUF4927	714..801	CDD:465083	11/54 (20%)
		Nuc_rec_co-act	1056..1102	CDD:462608
		Med15	1094..>1395	CDD:312941
		DUF1518	1270..1327	CDD:462174