DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and Ncoa2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_017174718.1	Gene:	Ncoa2 / 17978	MGIID:	1276533	Length:	1517	Species:	Mus musculus

Alignment Length:	945	Identity:	175/945 - (18%)
Similarity:	293/945 - (31%)	Gaps:	321/945 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SGSGSGSSSDPAN-------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSR 71
            ||.|. ::|||:.             |...:...||:.|::.|..|:|||.::    ......:.
Mouse     2 SGMGE-NTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNF 65

  Fly    72 RLDKTAVLRFATHGLRLQYVFGKSASR---RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLL 133
            :.||.|:|:.....:|......|:|:.   ..:|:.:..||.     |.:...:  |...:::.|
Mouse    66 KPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQ-----GVIDKDA--LGPMMLEAL 123

  Fly   134 DCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQ 198
            |..|..:...|.:|.||.:|.|.|.:.|.:|..:::..|.|..|.....:.|:|:.:.      .
Mouse   124 DGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMV------N 182

  Fly   199 HHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEA-------------DDDEDHP- 249
            .....|..|::.|.:.:.......|.:.|.|..:.:...|:.||             ::.||..
Mouse   183 GGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKEEGEDLQS 247

  Fly   250 ----YNRRTPSPRR------------------MAHLATIDDRLRMD-------RRCFTVRLARAS 285
                ..||.|...|                  :..|.|...|..|.       |||    :.:..
Mouse   248 CLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRC----IQKFH 308

  Fly   286 TRAE------ATRHYERVKIDGC-------FRRSD---------SSLTGGAAANYP-IVSQLIRR 327
            |:.|      |.||:..|...|.       |..||         |.|......|.| :|..|...
Mouse   309 TQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHML 373

  Fly   328 SRNNNMLAAAAAVAAEAATVP--------PQHDAIAQAALHGISGNDIVL--------------- 369
            .|..|:......:..:|...|        |.|    ||...|..|.|:.|
Mouse   374 HREQNVCVMNPDLTGQAMGKPLNPISSSSPAH----QALCSGNPGQDMTLGSNINFPMNGPKEQM 434

  Fly   370 -VAMAR-----------------------VLREERPPEETEG----------------TVGLTIY 394
             :.|.|                       .|:...|.:.:.|                :.|:...
Mouse   435 GMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGS 499

  Fly   395 RQPEPYQL----EYHT----------RHLIDGSIIDCDQRIG---------------LVAGYMKD 430
            .:..|.|.    ..|:          .|....|.::..|.:.               |..|.:::
Mouse   500 PRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQN 564

  Fly   431 EVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGE-----------SCYRLLSRNGRFIYLHTKG 484
            ...|::|.....:..:        ...||...|||           ||:.
Mouse   565 SPVNMNPPPLSKMGSL--------DSKDCFGLYGEPSEGTTGQAEASCHP--------------- 606

  Fly   485 FLEVDRGSN-------------KVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPT----- 531
              |..:|.|             :.||     .|.|.:...:.:|.:..|...:..:.:|:
Mouse   607 --EEQKGPNDSSMPQAASGDRAEGHS-----RLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDT 664

  Fly   532 -QSSSPDLPA-----SQAPQQLERIVLYLIENLQKSVDSAE-TVGGQGMESLMDDGYSSPANTLT 589
             :.|:..||.     ..:.::..:|:..|:::....||.|: |....|.|...:...::|.:.:|
Mouse   665 NKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVT 729

  Fly   590 LEELAPSP-------------------------TPAL----ALVPPAPSSVKSSISKSVSVVNVT 625
            :::...||                         ||.|    :...||      |.:|.:::..|.
Mouse   730 VKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPA------SNTKLIAMKTVK 788

  Fly   626 AARKFQQEHQKQRERD--REQLKERTNSTQGVIRQLSSCLSE----AETAS----CILSPASSLS 680
            ....|:...|...|.|  .|.|.:..||      ||.....:    |.|.|    .|::....|:
Mouse   789 EEVSFEPSDQPGSELDNLEEILDDLQNS------QLPQLFPDTRPGAPTGSVDKQAIINDLMQLT 847

  Fly   681 ASEAPDTPDPHSNTSPPPSLHT----RPSVLHRTL 711
            |..:|..|......:...|..|    ||..|.|.|
Mouse   848 ADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	12/52 (23%)
		PAS	137..>186	CDD:238075	13/48 (27%)
		PAS_11	403..510	CDD:291273	22/155 (14%)
Ncoa2	XP_017174718.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	14/62 (23%)
		PAS	118..175	CDD:214512	15/56 (27%)
		PAS_11	268..378	CDD:405306	24/113 (21%)
		NCOA_u2	463..587	CDD:406952	16/131 (12%)
		SRC-1	636..709	CDD:400955	12/72 (17%)
		DUF4927	731..816	CDD:406644	16/90 (18%)
		Nuc_rec_co-act	1076..1120	CDD:400942
		Med15	<1130..>1408	CDD:312941
		DUF1518	1284..1341	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900