DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and Ncoa1

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_006515068.1	Gene:	Ncoa1 / 17977	MGIID:	1276523	Length:	1447	Species:	Mus musculus

Alignment Length:	812	Identity:	162/812 - (19%)
Similarity:	274/812 - (33%)	Gaps:	239/812 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SGSGSGSSSDPAN-------GREARNLA---EKQRRDKLNASIQELATM----VPHAAESSRRLD 74
            ||.|. |||||||       |.....||   ||:||::.|..::|||.:    :......|.:.|
Mouse     2 SGLGD-SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPD 65

  Fly    75 KTAVLRFATHGLRLQYVFGKSASRRRKKT--GLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCF 137
            |..:|:.....::|.    |...:.:..|  .::.:.:|:|..|.:...|  |...|::.||..|
Mouse    66 KCKILKKTVDQIQLM----KRMEQEKSTTDDDVQKSDISSSSQGVIEKES--LGPLLLEALDGFF 124

  Fly   138 LTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQ 202
            ..:.|.|:||.||.:|...||:.|.:|...::..|.|..|.....:.|:|:.:           .
Mouse   125 FVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSL-----------V 178

  Fly   203 QGHNPQQHSTSTSASTSGSDL-----EEEEMETEE----------HRLGRQQGEADDDEDHP--- 249
            .|....|.:|..::.|....:     |:...|.:|          ..:.:.:...:|.||..
Mouse   179 NGVPWPQEATRRNSHTFNCRMLIHPPEDPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCL 243

  Fly   250 --YNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEATRHYE---RVKIDGCFR---RS 306
              ..||.|.|..:..:.:.  ..:.|.....:.:..:|.||.....:|   |..|...|:   |.
Mouse   244 ICIARRLPRPPAITGVESF--MTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGRE 306

  Fly   307 DS--------SLTGGAAA--NYPIVSQLIRRSRNNNMLAAAA--------------------AVA 341
            .|        .:|.|.|:  :|..:      ..:..||:|..                    .:.
Mouse   307 PSYARQLFQEVMTRGTASSPSYRFI------LNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIID 365

  Fly   342 AEAATVPPQHDAIAQAAL--------------HGI--------SGNDIVLVAMARVLREERPPEE 384
            .|.:.:.||.|:.:..::              ||:        |.|::|   .|||.|::.....
Mouse   366 REHSGLSPQDDSNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMV---SARVNRQQSSDLN 427

  Fly   385 TEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWV 449
            :..:                ||....:.....|.....:||.
Mouse   428 SSSS----------------HTNSSNNQGNFGCSPGNQIVAN----------------------- 453

  Fly   450 IVALRQMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKV 514
             |||.|        |::                        ||...:..|.:|....|..|....
Mouse   454 -VALNQ--------GQA------------------------GSQSSNPSLNLNNSPMEGTGIALS 485

  Fly   515 QEMKEK----FSTIIKAEMPTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMES 575
            |.|..:    .....:|.|...|..|::|...:|   ..|......|..:|..:......|||..
Mouse   486 QFMSPRRQANSGLATRARMSNNSFPPNIPTLSSP---VGITSGACNNNNRSYSNIPVTSLQGMNE 547

  Fly   576 LMDDGYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRER 640
            ..::.....|.:..|.:::...:|:...:.||.:..|.| .:..|::|    ...|.::......
Mouse   548 GPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDS-KEIASILN----EMIQSDNSDNSAN 607

  Fly   641 D-----------REQLKE---RTNSTQGVIRQLSSCLSEAE------TASC--ILS-PASSLSAS 682
            :           .::|.|   :.:.|...:.||.:..:|.:      ..||  :|| ..:|.|||
Mouse   608 EGKPLDSGLLHNNDRLSEGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSAS 672

  Fly   683 EAPD---TPDPHSNTSPPPSLHTRPSVLHRTL 711
            ..|.   .|..||      ||..|..:|||.|
Mouse   673 SNPSGGTCPSSHS------SLTERHKILHRLL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	14/55 (25%)
		PAS	137..>186	CDD:238075	15/48 (31%)
		PAS_11	403..510	CDD:291273	15/106 (14%)
Ncoa1	XP_006515068.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	16/63 (25%)
		PAS	120..213	CDD:238075	25/103 (24%)
		PAS_11	260..370	CDD:405306	18/117 (15%)
		NCOA_u2	469..591	CDD:406952	25/125 (20%)
		SRC-1	636..712	CDD:400955	22/69 (32%)
		DUF4927	747..824	CDD:406644
		Nuc_rec_co-act	930..975	CDD:400942
		Med15	980..>1366	CDD:312941
		DUF1518	1155..1211	CDD:400033
		DUF1518	1218..1274	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900