DRSC/TRiP Functional Genomics Resources

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Protein Alignment Met and Epas1

DIOPT Version :10

Sequence 1:NP_511126.2 Gene:Met / 32114 FlyBaseID:FBgn0002723 Length:716 Species:Drosophila melanogaster
Sequence 2:NP_034267.3 Gene:Epas1 / 13819 MGIID:109169 Length:874 Species:Mus musculus


Alignment Length:814 Identity:156/814 - (19%)
Similarity:250/814 - (30%) Gaps:313/814 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 SSDPANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKS 95
            ||......::|: |.:.||.|......|||..:|.....|..|||.:::|.|...||...:....
Mouse    10 SSSELRKEKSRD-AARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSV 73

  Fly    96 ASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHC 160
            .|....:.           ..|....:|:|     :.|:.....:|..|.::.:|.::.:.:|..
Mouse    74 CSENESEA-----------EADQQMDNLYL-----KALEGFIAVVTQDGDMIFLSENISKFMGLT 122

  Fly   161 QSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEE 225
            |.:|.|.::...|||.|.:.:|:.|                            |..:.||...:.
Mouse   123 QVELTGHSIFDFTHPCDHEEIRENL----------------------------TLKNGSGFGKKS 159

  Fly   226 EEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEA 290
            :::.||.....|.:                        .|:.:|.|      ||.|..|:.:...
Mouse   160 KDVSTERDFFMRMK------------------------CTVTNRGR------TVNLKSATWKVLH 194

  Fly   291 TRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIA 355
            .....|| .:.|  ...|||.|   :..|::|.||              :..|    |.||.   
Mouse   195 CTGQVRV-YNNC--PPHSSLCG---SKEPLLSCLI--------------IMCE----PIQHP--- 232

  Fly   356 QAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQR 420
                   |..||.|.:..                              :.:||.:|.....||.|
Mouse   233 -------SHMDIPLDSKT------------------------------FLSRHSMDMKFTYCDDR 260

  Fly   421 IGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESC---------YRLLSRNGR 476
            |..:.||..:|:...|.:.|.|..|..          :....:...|         ||:|:::|.
Mouse   261 ILELIGYHPEELLGRSAYEFYHALDSE----------NMTKSHQNLCTKGQVVSGQYRMLAKHGG 315

  Fly   477 FIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQ----------------------------- 512
            :::|.|:|.:..:..:.:....:|||.:|.|.....                             
Mouse   316 YVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSDDV 380

  Fly   513 -----------KVQEMKEKFSTII------------------------KAEMP------------ 530
                       |::|..|:.:.:.                        ||.:|            
Mouse   381 AVTEKSNYLFTKLKEEPEELAQLAPTPGDAIISLDFGSQNFDEPSAYGKAILPPGQPWVSGLRSH 445

  Fly   531 -TQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSS----------- 583
             .||.|..|||...||         .:....:..||.:.......|..:|.|||           
Mouse   446 SAQSESGSLPAFTVPQ---------ADTPGNTTPSASSSSSCSTPSSPEDYYSSLENPLKIEVIE 501

  Fly   584 -----------PANT------LTLEELAP-----------SP-TPALALVPPAPS-------SVK 612
                       |.:|      |.||.|||           || .|...|:|.:|.       |..
Mouse   502 KLFAMDTEPRDPGSTQTDFSELDLETLAPYIPMDGEDFQLSPICPEEPLMPESPQPTPQHCFSTM 566

  Fly   613 SSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNST----QGVIRQLSSCLSEAETASCIL 673
            :||.:.:: ...|....|..::.:|.|..:.:.:....|:    .|....||.|..:|.|     
Mouse   567 TSIFQPLT-PGATHGPFFLDKYPQQLESRKTESEHWPMSSIFFDAGSKGSLSPCCGQAST----- 625

  Fly   674 SPASSLSASEAPDTPDPHSNTS--PPPSLHTRPS 705
             |.||:..         .|||.  |.|.||..|:
Mouse   626 -PLSSMGG---------RSNTQWPPDPPLHFGPT 649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MetNP_511126.2 bHLH_PAS 38..89 CDD:381397 17/50 (34%)
PAS 137..>186 CDD:238075 12/48 (25%)
PAS_11 401..510 CDD:464214 27/117 (23%)
Epas1NP_034267.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 3/13 (23%)
bHLH-PAS_HIF2a_PASD2 9..74 CDD:381571 19/64 (30%)
DNA-binding. /evidence=ECO:0000269|PubMed:26245371 26..53 9/26 (35%)
PAS 86..147 CDD:214512 15/65 (23%)
Required for heterodimer formation with ARNT. /evidence=ECO:0000269|PubMed:26245371 171..192 8/50 (16%)
PAS_3 254..341 CDD:430001 20/96 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..489 12/59 (20%)
NTAD 495..541 8/45 (18%)
HIF-1 516..548 CDD:463274 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..803
CTAD 834..874
HIF-1a_CTAD 837..873 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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