Protein Alignment Met and Ahr

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_038492.1
• Gene: Ahr / 11622
• MGIID: 105043
• Length: 805
• Species: Mus musculus
• Alignment Length: 790
• Identity: 155/790 - (19%)
• Similarity: 266/790 - (33%)
• Gaps: 241/790 - (30%)

  Fly    34 PANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG---KS 95
            ||.|  .::...|:.||:||..:..||:::|...:...:|||.:|||.:...||.:..|.   ||
Mouse    26 PAEG--IKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKS 88

  Fly    96 ASRRRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHC 160
            ....|.    .|.....:.:.|..:  |...:.|:|.|:...|.:|....:...|::::..||..
Mouse    89 TPADRN----GGQDQCRAQIRDWQD--LQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQ 147

  Fly   161 QSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEE 225
            |||:..|::.::.|.:|:...::||                        |......|..|.|
Mouse   148 QSDVIHQSVYELIHTEDRAEFQRQL------------------------HWALNPDSAQGVD--- 185

  Fly   226 EEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATID----DRLRMDRRCFTVRLARAST 286
                 |.|                      .|.:.|...|.|    :......|||..||
Mouse   186 -----EAH----------------------GPPQAAVYYTPDQLPPENASFMERCFRCRL----- 218

  Fly   287 RAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQH 351
                     |..:|        :.:|..|.|:         ......|........:.|.:|||
Mouse   219 ---------RCLLD--------NSSGFLAMNF---------QGRLKYLHGQNKKGKDGALLPPQ- 256

  Fly   352 DAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIID 416
                           :.|.|:|..|   :||...|......|:|          |:|.:|.:.|.
Mouse   257 ---------------LALFAIATPL---QPPSILEIRTKNFIFR----------TKHKLDFTPIG 293

  Fly   417 CDQRIGLVAGYMKDEV-RNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIYL 480
            ||.:..|:.||.:.|: ...|.:.|:|..|:.....:..:|.. ..:.|.:.:|||:::.|:.::
Mouse   294 CDAKGQLILGYTEVELCTRGSGYQFIHAADILHCAESHIRMIK-TGESGMTVFRLLAKHSRWRWV 357

  Fly   481 HTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQ------------------EMKEKFSTIIKA 527
            .:...| :.|.....:.......|.||| ||:.:|                  |:...||.|:.
Mouse   358 QSNARL-IYRNGRPDYIIATQRPLTDEE-GREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMD- 419

  Fly   528 EMPTQSSSPDLPASQAP-------------------QQLERIVL------------YLIENLQKS 561
            .:|.::.|.......||                   ||.|.|.|            :|:.::.|.
Mouse   420 PLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPALLDSHFLMGSVSKC 484

  Fly   562 VDSAETVGGQGMESLMDD---GYSSPANTLTLEELAPSPTPALALVPPAPSSVKSSISKSVSVVN 623
            ....::....|.|:.:..   |::...|      ||.|..|: .|.|...::...||.:::. ::
Mouse   485 GSWQDSFAAAGSEAALKHEQIGHAQDVN------LALSGGPS-ELFPDNKNNDLYSIMRNLG-ID 541

  Fly   624 VTAARKFQQEHQKQRE---------RDREQLKERTNSTQGVIRQL----SSCLSEAET--ASCIL 673
            ....|..|.|...:.:         :|.:...|.....|..:...    |:|..:..|  .||:|
Mouse   542 FEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCML 606

  Fly   674 SPASSLSASEAPDTPDPHS-------------------------------NTSPPPSLH-TRPSV 706
            .....|...:....|.|.:                               |.:||.|.: .:..:
Mouse   607 QERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQEL 671

  Fly   707 LHRTLTSTLR 716
            .|..|.|:|:
Mouse   672 KHYQLFSSLQ 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	16/50 (32%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	26/109 (24%)
Ahr	NP_038492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		4/13 (31%)
		Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869	12..15
		bHLH-PAS_AhR	27..87	CDD:381442	19/61 (31%)
		Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869	36..41		2/4 (50%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869	37..65		8/27 (30%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869	49..81		11/31 (35%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869	63..71		5/7 (71%)
		PAS	111..>177	CDD:395786	17/89 (19%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	116..124		3/7 (43%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	260..262		0/1 (0%)
		PAS_3	291..376	CDD:430001	19/86 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..449		4/27 (15%)