Protein Alignment Met and NCOA2

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_016868450.1
• Gene: NCOA2 / 10499
• HGNCID: 7669
• Length: 1533
• Species: Homo sapiens
• Alignment Length: 830
• Identity: 162/830 - (19%)
• Similarity: 258/830 - (31%)
• Gaps: 279/830 - (33%)

  Fly    24 SGSGSGSSSDPAN-------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSR 71
            ||.|. ::|||:.             |...:...||:.|::.|..|:|||.::    ......:.
Human     2 SGMGE-NTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNF 65

  Fly    72 RLDKTAVLRFATHGLRLQYVFGKSASR---RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLL 133
            :.||.|:|:.....:|......|:|:.   ..:|:.:..||.     |.:...:  |...:::.|
Human    66 KPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQ-----GVIDKDA--LGPMMLEAL 123

  Fly   134 DCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQ 198
            |..|..:...|.:|.||.:|.|.|.:.|.:|..:::..|.|..|.....:.|:|:.|.      .
Human   124 DGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIV------N 182

  Fly   199 HHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEA-------------DDDEDHP- 249
            .....|..|:::|.:.:.......|.:.|.|..:::...|:.|.             ::.||..
Human   183 GGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQS 247

  Fly   250 ----YNRRTPSPRR------------------MAHLATIDDRLRMD-------RRCFTVRLARAS 285
                ..||.|...|                  :..|.|...|..|.       |||  ::...|.
Human   248 CLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRC--IQKFHAQ 310

  Fly   286 TRAE----ATRHYERVKIDGC-------FRRSD---------SSLTGGAAANYP-IVSQLIRRSR 329
            ...|    |.||:..|...|.       |..||         |.|......|.| :|..|....|
Human   311 HEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHR 375

  Fly   330 NNNMLAAAAAVAAEAATVP--------PQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETE 386
            ..|:......:..:....|        |.|    ||...|..|.|:.|.:....     |....:
Human   376 EQNVCVMNPDLTGQTMGKPLNPISSNSPAH----QALCSGNPGQDMTLSSNINF-----PINGPK 431

  Fly   387 GTVGLTIYR------------------QPEPYQLEYHT-------------------RHLIDGSI 414
            ..:|:.:.|                  |...|.|:.::                   ||.:...
Human   432 EQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPG- 495

  Fly   415 IDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIY 479
                     |||..:......||...:|                  |..|
Human   496 ---------VAGSPRIPPSQFSPAGSLH------------------SPVG--------------- 518

  Fly   480 LHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDL------ 538
                    |...:...||:  .|:.|:      .:|.:.|.....:.:.:    :||||
Human   519 --------VCSSTGNSHSY--TNSSLN------ALQALSEGHGVSLGSSL----ASPDLKMGNLQ 563

  Fly   539 --PASQAPQQLERIVLYLIENLQKSVDSAETVG--GQGMESLMDDGYSS--PANTLTLEELAPSP 597
              |.:..|..|.::         .|:||.:..|  |:..|.......||  |.      |...:.
Human   564 NSPVNMNPPPLSKM---------GSLDSKDCFGLYGEPSEGTTGQAESSCHPG------EQKETN 613

  Fly   598 TPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSC 662
            .|.|   |||.||                            ||...|.:...:..|..:.||.:.
Human   614 DPNL---PPAVSS----------------------------ERADGQSRLHDSKGQTKLLQLLTT 647

  Fly   663 LSEAETASCILSPASSLSASEAPDTPD-PHSNTSPPPSLHTRPSVLHRTL 711
            .|:....|.:   |||||.:....|.. |.|.::...||..:..:|||.|
Human   648 KSDQMEPSPL---ASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLL 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	13/54 (24%)
		PAS	137..>186	CDD:238075	13/48 (27%)
		PAS_11	401..510	CDD:464214	16/127 (13%)
NCOA2	XP_016868450.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	14/62 (23%)
		PAS	118..175	CDD:214512	15/56 (27%)
		PAS_11	268..378	CDD:464214	24/111 (22%)
		NCOA_u2	463..587	CDD:465223	29/195 (15%)
		SRC-1	636..709	CDD:462615	19/62 (31%)
		DUF4927	731..816	CDD:465083
		Nuc_rec_co-act	1071..1115	CDD:462608
		DUF1518	1351..1407	CDD:462174