Protein Alignment Met and NCOA2

DIOPT Version :9

• Sequence 1: NP_001285132.1
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: XP_016868450.1
• Gene: NCOA2 / 10499
• HGNCID: 7669
• Length: 1533
• Species: Homo sapiens
• Alignment Length: 830
• Identity: 162/830 - (19%)
• Similarity: 258/830 - (31%)
• Gaps: 279/830 - (33%)

  Fly    24 SGSGSGSSSDPAN-------------GREARNLAEKQRRDKLNASIQELATMV----PHAAESSR 71
            ||.|. ::|||:.             |...:...||:.|::.|..|:|||.::    ......:.
Human     2 SGMGE-NTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNF 65

  Fly    72 RLDKTAVLRFATHGLRLQYVFGKSASR---RRKKTGLKGTGMSASPVGDLPNPSLHLTDTLMQLL 133
            :.||.|:|:.....:|......|:|:.   ..:|:.:..||.     |.:...:  |...:::.|
Human    66 KPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQ-----GVIDKDA--LGPMMLEAL 123

  Fly   134 DCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQ 198
            |..|..:...|.:|.||.:|.|.|.:.|.:|..:::..|.|..|.....:.|:|:.|.      .
Human   124 DGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIV------N 182

  Fly   199 HHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEA-------------DDDEDHP- 249
            .....|..|:::|.:.:.......|.:.|.|..:::...|:.|.             ::.||..
Human   183 GGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQS 247

  Fly   250 ----YNRRTPSPRR------------------MAHLATIDDRLRMD-------RRCFTVRLARAS 285
                ..||.|...|                  :..|.|...|..|.       |||  ::...|.
Human   248 CLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRC--IQKFHAQ 310

  Fly   286 TRAE----ATRHYERVKIDGC-------FRRSD---------SSLTGGAAANYP-IVSQLIRRSR 329
            ...|    |.||:..|...|.       |..||         |.|......|.| :|..|....|
Human   311 HEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHR 375

  Fly   330 NNNMLAAAAAVAAEAATVP--------PQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETE 386
            ..|:......:..:....|        |.|    ||...|..|.|:.|.:....     |....:
Human   376 EQNVCVMNPDLTGQTMGKPLNPISSNSPAH----QALCSGNPGQDMTLSSNINF-----PINGPK 431

  Fly   387 GTVGLTIYR------------------QPEPYQLEYHT-------------------RHLIDGSI 414
            ..:|:.:.|                  |...|.|:.::                   ||.:...
Human   432 EQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPG- 495

  Fly   415 IDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCYRLLSRNGRFIY 479
                     |||..:......||...:|                  |..|
Human   496 ---------VAGSPRIPPSQFSPAGSLH------------------SPVG--------------- 518

  Fly   480 LHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDL------ 538
                    |...:...||:  .|:.|:      .:|.:.|.....:.:.:    :||||
Human   519 --------VCSSTGNSHSY--TNSSLN------ALQALSEGHGVSLGSSL----ASPDLKMGNLQ 563

  Fly   539 --PASQAPQQLERIVLYLIENLQKSVDSAETVG--GQGMESLMDDGYSS--PANTLTLEELAPSP 597
              |.:..|..|.::         .|:||.:..|  |:..|.......||  |.      |...:.
Human   564 NSPVNMNPPPLSKM---------GSLDSKDCFGLYGEPSEGTTGQAESSCHPG------EQKETN 613

  Fly   598 TPALALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSC 662
            .|.|   |||.||                            ||...|.:...:..|..:.||.:.
Human   614 DPNL---PPAVSS----------------------------ERADGQSRLHDSKGQTKLLQLLTT 647

  Fly   663 LSEAETASCILSPASSLSASEAPDTPD-PHSNTSPPPSLHTRPSVLHRTL 711
            .|:....|.:   |||||.:....|.. |.|.::...||..:..:|||.|
Human   648 KSDQMEPSPL---ASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLL 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	12/52 (23%)
		PAS	137..>186	CDD:238075	13/48 (27%)
		PAS_11	403..510	CDD:291273	15/125 (12%)
NCOA2	XP_016868450.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810