DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Met and ncoa2

DIOPT Version :9

Sequence 1:	NP_001285132.1	Gene:	Met / 32114	FlyBaseID:	FBgn0002723	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001135631.1	Gene:	ncoa2 / 100216190	XenbaseID:	XB-GENE-482311	Length:	1440	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	156/754 - (20%)
Similarity:	248/754 - (32%)	Gaps:	249/754 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SGSGSGSGSGSSSDPANGREA--------RNLAEKQRRDKLNASIQELATMVPHAAESSRRL--- 73
            ||.|......|.::|...:|:        :...||:.|::.|..|:|||.::.........|
Frog     2 SGMGENPSDPSRAEPRKRKESIDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNLNFK 66

  Fly    74 -DKTAVLRFATHGLRLQYVFGKSASRRR---KKTGLKGTGMSA---SPVGDLPNPSLHLTDTLMQ 131
             ||.|:|:.....:|......|:|:...   :|..:..||.|.   ..:|.:          :::
Frog    67 PDKCAILKETVKQIRQIKEHEKTAAANEDEVQKADVSSTGQSVIDKDALGPM----------MLE 121

  Fly   132 LLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQ 196
            .||..|..:...|.:|.||.:|.|.|.:.|.:|...::..|.|..|.....:.|:|:.|
Frog   122 ALDGFFFVVNREGNVVFVSENVTQYLRYNQEELMNTSVYSILHVGDHSEFIKNLLPKSI------ 180

  Fly   197 HQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMA 261
                  ....|:::|.:.:...    |.:..||.||        |..|.::......|
Frog   181 ------VNGGPRRNSHTFNCRM----LVKPMMECEE--------EGHDGQETHQKYET------- 220

  Fly   262 HLATIDDRLRMDRRCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIR 326
                        .:||.|...::            :|.:|
Frog   221 ------------MQCFAVSQPKS------------IKEEG------------------------- 236

  Fly   327 RSRNNNMLAAAAAVAAEAATVPPQHDAI-AQAALHG-ISGNDIVLVAMARVLREERPPEETEGTV 389
            ....:.::..|..|..:...|||..::. .:..|.| |:..|   ....|.|.  ||  ..|..|
Frog   237 EDFQSCLICVARRVPMKERPVPPPSESFTTRQDLQGKITSLD---TTNMRALM--RP--GWEDLV 294

  Fly   390 GLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALR 454
            ...|.|        :|::|  ||.|           .|.|           .|..:|      ||
Frog   295 RRCIQR--------FHSQH--DGEI-----------SYSK-----------RHHQEV------LR 321

  Fly   455 QMYDCNSDYGESCYRLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEE---------AG 510
            |.: ..|.:    ||....:|..:..|||..|...:.:|:....|.::.|..|:         ||
Frog   322 QGH-ATSPF----YRFALSDGTTVLAHTKSKLMRSQTTNEPQLVLSLHVLQREQNMCGLNQDLAG 381

  Fly   511 RQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQA-----PQQ---LERIVLYLIENLQKSVDSA-- 565
                |.|.:..:       |.||||   ||.||     |.|   :...:.|.|...::.:..|
Frog   382 ----QAMGKTLN-------PVQSSS---PAHQAMYGGNPGQDTTISSNMNYAITGPKEQMGMAAG 432

  Fly   566 ETVGGQGMESLMDDGYSSP-ANTLTLEELAPSP--------------------TPALALVP---P 606
            ..||..||..:.....::| .|...|:..:||.                    :|.:|..|   |
Frog   433 RFVGSGGMNHISSLQATTPQGNNYALKINSPSQGSPGMGQGQPNSMLSPRHRVSPGVAGSPRIAP 497

  Fly   607 APSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQGVIRQLSSCLSEAETASC 671
            :..|...|:...|||.:.|.     ..|            ..|||:...::.||      |....
Frog   498 SQFSPAGSLHSPVSVCSSTG-----NSH------------SYTNSSLNALQALS------EGHGV 539

  Fly   672 ILSPASSLSASEAPDTPDPHSNTSP----PPSLHTRPSV 706
            .|:|..|     :||....:...||    ||.|....|:
Frog   540 PLAPPLS-----SPDLKVGNVQHSPVNMNPPQLRKMGSI 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_001285132.1	HLH	38..87	CDD:238036	14/60 (23%)
		PAS	137..>186	CDD:238075	13/48 (27%)
		PAS_11	403..510	CDD:291273	24/115 (21%)
ncoa2	NP_001135631.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		8/37 (22%)
		bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	15/62 (24%)
		PAS	118..175	CDD:214512	15/66 (23%)
		PAS_11	262..371	CDD:373151	36/158 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..409		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..521		15/84 (18%)
		NCOA_u2	456..580	CDD:374708	31/146 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..571		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..656
		SRC-1	626..703	CDD:370145
		LXXLL motif 1. /evidence=ECO:0000255	631..635
		LXXLL motif 2. /evidence=ECO:0000255	684..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..731
		DUF4927	725..812	CDD:374467
		LXXLL motif 3. /evidence=ECO:0000255	739..743
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	948..970
		PRK10263	<950..>1242	CDD:236669
		Nuc_rec_co-act	1066..1111	CDD:312376
		LLXXLXXXL motif. /evidence=ECO:0000255	1074..1082
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1287..1306
		DUF1518	1288..1344	CDD:369380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910