Protein Alignment Met and clock

DIOPT Version :10

• Sequence 1: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001122127.1
• Gene: clock / 100038163
• XenbaseID: XB-GENE-495448
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 653
• Identity: 139/653 - (21%)
• Similarity: 240/653 - (36%)
• Gaps: 206/653 - (31%)

  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102
            |.:||.:||:|||:.|..|:||.:|:|   .::||:||:.||:.:...||........:.....:
 Frog    27 RVSRNKSEKRRRDQFNILIKELGSMLP---GNARRMDKSTVLQKSIDFLRKHKEISAQSDASEIR 88

  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167
            ...|.|.:|          :...|..:::.||..||.:...|.|:.||.||..||.|..|||..|
 Frog    89 QDWKPTFLS----------NEEFTQLMLEALDGFFLAVMTDGNIIYVSESVTSLLEHLPSDLVDQ 143

  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGSDLEEEEMETEE 232
            ::.... |:.:                          |:......||....||| |..|.::|:.
 Frog   144 SIFNFV-PEGE--------------------------HSEVYKILSTRMLESGS-LSSEYLKTKN 180

  Fly   233 ------HRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEAT 291
                  |.|   :|.||..|        ||.
 Frog   181 ELEFCCHML---RGTADPKE--------PST---------------------------------- 200

  Fly   292 RHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQ 356
              ||.||..|.|:    ||....::.:......::||..                 ||..:.:..
 Frog   201 --YEFVKFIGNFK----SLNNVPSSTHNGFDGALQRSLR-----------------PPYEERVCF 242

  Fly   357 AALHGISGNDIVLVAMARVLREERPPEE-TEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQR 420
            .|        .|.:|..:.::|....|| ||                |:.:||.::...:..|.|
 Frog   243 VA--------TVRLATPQFIKEMCTVEESTE----------------EFTSRHSLEWKFLFLDHR 283

  Fly   421 IGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDY-----GESC-YRLLSRNGRFIY 479
            ...:.||:..||...|.:.:.|:||       |..:..|:...     |:|| ||.|::..::|:
 Frog   284 APPIIGYLPFEVLGTSGYDYYHVDD-------LENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIW 341

  Fly   480 LHTKGFLEVDRGSNKVHSFLCVNTLLD-EEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQA 543
            |.|:.::...:.:::....:|.:|::. .|.|.::            :.|...:.|.|.:.|.
 Frog   342 LQTRYYITYHQWNSRPEFIVCTHTVVSYAEVGAER------------RRERGIEDSPPAITAD-- 392

  Fly   544 PQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELAPSPTPALALVPPAP 608
                                       :..:|:.|:..::.:....||....|.||:    |.:.
 Frog   393 ---------------------------KNQDSVSDNHMNTVSLKEALERFDDSRTPS----PSSK 426

  Fly   609 SSVKSSISKSVSVVNVTAARKFQQEHQKQR------ERDREQLKERTNSTQGVIRQLSSCLSEAE 667
            ||:|||...:||..:.|..:...:.....|      ::.|..:..::.|:|.|.:.||..:.: :
 Frog   427 SSIKSSSHTAVSDPSSTPTKITTETSTPPRQAITGLDKRRSSVSSQSMSSQSVSQALSQSVMK-Q 490

  Fly   668 TAS 670
            |||
 Frog   491 TAS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	22/50 (44%)
		PAS	137..>186	CDD:238075	16/48 (33%)
		PAS_11	401..510	CDD:464214	27/115 (23%)
clock	NP_001122127.1	bHLH-PAS_CLOCK	20..80	CDD:381577	22/55 (40%)
		PAS	100..>188	CDD:395786	28/115 (24%)
		PAS_11	264..368	CDD:464214	28/126 (22%)
		SP1-4_N	541..>717	CDD:425404