DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1703 and NEW1

DIOPT Version :9

Sequence 1:	NP_001285130.1	Gene:	CG1703 / 32112	FlyBaseID:	FBgn0030321	Length:	901	Species:	Drosophila melanogaster
Sequence 2:	NP_015098.1	Gene:	NEW1 / 855875	SGDID:	S000006147	Length:	1196	Species:	Saccharomyces cerevisiae

Alignment Length:	839	Identity:	221/839 - (26%)
Similarity:	330/839 - (39%)	Gaps:	287/839 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 EKEVEEQKVEQV--LSEKVAAVSLKEKTPEPVPKAEPEPESEPQPDEEADAEVDSKFE---ESKE 289
            :|.|:...:.:|  |:||...| |||                   |:|||.|  :||.   ..:|
Yeast   436 QKVVDTASLPEVRELAEKALNV-LKE-------------------DDEADKE--NKFSGRLTLEE 478

  Fly   290 AKEKKLTHKEKKK--------------------------QKKQQEYERQMELMTKKGGAGHS--- 325
            .::..|.|.:..|                          .....:::|..:.:|...|...|
Yeast   479 GRDFLLDHLKDIKADDSCFVKPYMNDETVIKYMSKILTVDSNVNDWKRLEDFLTAVFGGSDSQRE 543

  Fly   326 ----DLDNNFTMSQVQKSAGQKAALEQAVDIKIENFTISAKGNDLFVN-ANLLIAHGRRYGLVGP 385
                |..:|......|:.  ::|..::.::|...:|:: |.|:.:.:| .||.:..|.||||.|.
Yeast   544 FVKQDFIHNLRALFYQEK--ERADEDEGIEIVNTDFSL-AYGSRMLLNKTNLRLLKGHRYGLCGR 605

  Fly   386 NGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFV 450
            ||.||:||:|.||.......|:.|.|                       ||..:    |.:.|..
Yeast   606 NGAGKSTLMRAIANGQLDGFPDKDTL-----------------------RTCFV----EHKLQGE 643

  Fly   451 AGDL------TVQEELNDTFAELKAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVS 509
            .|||      .:.|||..|..|..|..           |..:||.:|.:.:.....||||:|::.
Yeast   644 EGDLDLVSFIALDEELQSTSREEIAAA-----------LESVGFDEERRAQTVGSLSGGWKMKLE 697

  Fly   510 LARALYLEPTLLMLDEPTNHLDLNAVIWLDNY-LQGWKKTLLIVSHDQSFLDNVCNEIIHLDQKK 573
            ||||:..:..:|:|||||||||::.|.||:.| |:....|.||||||..|||.||.:|||.:.||
Yeast   698 LARAMLQKADILLLDEPTNHLDVSNVKWLEEYLLEHTDITSLIVSHDSGFLDTVCTDIIHYENKK 762

  Fly   574 LQYYKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQ 638
            |.|||||.:.|    |:::                          .|.|...:||
Yeast   763 LAYYKGNLAAF----VEQK--------------------------PEAKSYYTLT---------- 787

  Fly   639 QKQDEDEGPQELLARPKEYIVKFRFPEPSQL------QPPILGVHNVTFAFP-SQKPLFIKVDFG 696
                 |...|            .|||.|..|      ...:..:.:|||::| :|||....|...
Yeast   788 -----DSNAQ------------MRFPPPGILTGVKSNTRAVAKMTDVTFSYPGAQKPSLSHVSCS 835

  Fly   697 IDLTSRVAIVGPNGVGKSTFLKLLLGELEPQEGEQRKNHRLHVGRFDQHSGEHLT--AEESAAEY 759
            :.|:||||.:||||.||||.:|||.|||.|.||:..|:..|.:|...||:.:|:.  .|::|.:|
Yeast   836 LSLSSRVACLGPNGAGKSTLIKLLTGELVPNEGKVEKHPNLRIGYIAQHALQHVNEHKEKTANQY 900

  Fly   760 LQRLFNL---------------------------------------------------------- 766
            ||..:..
Yeast   901 LQWRYQFGDDREVLLKESRKISEDEKEMMTKEIDIDDGRGKRAIEAIVGRQKLKKSFQYEVKWKY 965

  Fly   767 ---------------------------PHEKARKALGSFGLVSHAHTIKMKD------------- 791
                                       .||.:|:.||...|:....|...:|
Yeast   966 WKPKYNSWVPKDVLVEHGFEKLVQKFDDHEASREGLGYRELIPSVITKHFEDVGLDSEIANHTPL 1030

  Fly   792 --LSGGQKARVALAELCLSAPDVLILDEPTNNLDIESIDALAEAINEYEGGVIIVSHDERLIRET 854
              |||||..:|.:|....:.|.:|:||||||.||.:|:.|||.||.::.|||:::||:...:...
Yeast  1031 GSLSGGQLVKVVIAGAMWNNPHLLVLDEPTNYLDRDSLGALAVAIRDWSGGVVMISHNNEFVGAL 1095

  Fly   855 GCTLYVIED-QTINEIVGEFDDYRKE---VLDSLGEVVNN---PSV-----VANAAVLQ 901
            ....:::|: :.:.:...:.|..:.|   ..|::|...:|   |||     .||..|.|
Yeast  1096 CPEQWIVENGKMVQKGSAQVDQSKFEDGGNADAVGLKASNLAKPSVDDDDSPANIKVKQ 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1703	NP_001285130.1	Uup	351..879	CDD:223562	181/645 (28%)
		ABCF_EF-3	352..573	CDD:213188	81/228 (36%)
		ABC_tran_Xtn	567..>611	CDD:289608	12/43 (28%)
		ABCF_EF-3	676..865	CDD:213188	78/292 (27%)
NEW1	NP_015098.1	HEAT repeat	183..214	CDD:293787
		HEAT repeat	224..253	CDD:293787
		HEAT repeat	264..291	CDD:293787
		Uup	572..1122	CDD:223562	181/645 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810