DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1703 and HEF3

DIOPT Version :9

Sequence 1:	NP_001285130.1	Gene:	CG1703 / 32112	FlyBaseID:	FBgn0030321	Length:	901	Species:	Drosophila melanogaster
Sequence 2:	NP_014384.3	Gene:	HEF3 / 855718	SGDID:	S000004959	Length:	1044	Species:	Saccharomyces cerevisiae

Alignment Length:	1039	Identity:	231/1039 - (22%)
Similarity:	366/1039 - (35%)	Gaps:	401/1039 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PSKKNKKNKKKNDDFSDEDKPELDLDDLDNEEDEVEVVAVKP-------ASKKSKKKQQAQQKNM 186
            ||..:|...|.||......|.   |..:.:..:.|.|.|:.|       .|.|.|:| .|..:.:
Yeast    93 PSVCSKAGSKDNDVQLAATKA---LKAIASAVNPVAVKALLPHLIHSLETSNKWKEK-VAVLEVI 153

  Fly   187 FAMSDDEEDEVADDLP------NDSEEEEKEQLSNKAAKESKKEQQKQPEKEVEEQKVEQVLSEK 245
            ..:.|..::::|..:|      ::|..:.|     |..||:......:..:.|:.:.:|:.:.:.
Yeast   154 SVLVDAAKEQIALRMPELIPVLSESMWDTK-----KGVKEAATTTITKATETVDNKDIERFIPKL 213

  Fly   246 VAAVSLKEKTPEPVP-------KAEPEP---------------ESEPQPDEEADAEVDS--KFEE 286
            :..::...:.||.|.       .||..|               |.|.....:|...:|:  |..|
Yeast   214 IECIANPNEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKLVE 278

  Fly   287 ------------------------SKEAKEKKLTHKEKKKQKKQQEYERQMELMTKKGGAGHSDL 327
                                    ..||:|..|               :.::.:.:.|..|..|:
Yeast   279 DPQVVAPFLGKLLPGLKNNFATIADPEAREVTL---------------KALKTLRRVGNVGEDDV 328

  Fly   328 --------DNNFTMSQV------QKSA-------------------------------------- 340
                    |.:.|:..:      :|.|
Yeast   329 LPEISHAGDVSTTLGVIKELLEPEKVAPRFTIVVEYIAAIAANLIDERIIDQQTWFTHVTPYMTI 393

  Fly   341 --GQKAALEQAVDIK---IENFTIS--------------------AKGNDLFVN-ANLLIAHGRR 379
              .:|.|.|...|.:   ::|..:.                    |.|..:.:| ..|.:..|||
Yeast   394 FLHEKTAKEILDDFRKRAVDNIPVGPNFQDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRGRR 458

  Fly   380 YGLVGPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADE 444
            |||.||||.||:||:|.||.                                        .:.|.
Yeast   459 YGLCGPNGAGKSTLMRSIAN----------------------------------------GQVDG 483

  Fly   445 LEKQFVAGDLTVQEELNDTFAELKAIG-AYSAEARARRILAG----LGFSKEMQDRPTNKFSGGW 504
            ...|.....:.|:.::::|.:::..:. .||.....:.::..    .|||.||.:.|....||||
Yeast   484 FPTQDECRTVYVEHDIDNTHSDMSVLDFVYSGNVGTKDVITSKLKEFGFSDEMIEMPIASLSGGW 548

  Fly   505 RMRVSLARALYLEPTLLMLDEPTNHLDLNAVIWLDNYLQGWKKTLLIVSHDQSFLDNVCNEIIHL 569
            :|:::||||:..:..:|:|||||||||...|.||.|||.....|.:|||||..|||.||..|||.
Yeast   549 KMKLALARAVLKDADILLLDEPTNHLDTVNVEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHY 613

  Fly   570 DQKKLQYYKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKN 634
            :..||:.||||.|.|    |||.......||.
Yeast   614 EGLKLRKYKGNLSEF----VQKCPTAQSYYEL--------------------------------- 641

  Fly   635 KSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQL------QPPILGVHNVTFAFP-SQKPLFIK 692
                       |..:|         :|:||.|..|      |..|:.|.|:||.:| :.||....
Yeast   642 -----------GASDL---------EFQFPTPGYLEGVKTKQKAIVKVSNMTFQYPGTTKPQVSD 686

  Fly   693 VDFGIDLTSRVAIVGPNGVGKSTFLKLLLGELEPQEGEQRKNHRLHVGRFDQHSGEHLTA--EES 755
            |.|...|:||:|::||||.||||.:.:|.|||.|..||...:....:....||:..|:.:  :::
Yeast   687 VTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKT 751

  Fly   756 AAEYLQRLFN------------------------------------------------------- 765
            .:||:|..|.
Yeast   752 PSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRVAGIHSRRKFKNTYEYECSF 816

  Fly   766 -----------------------LP-------HEK------ARKAL--GSF-------------- 778
                                   ||       |.|      .::||  |.|
Yeast   817 LLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMVAEIDMKEALASGQFRALTRKEIELHCAM 881

  Fly   779 -----GLVSHAHTIKMKDLSGGQKARVALAELCLSAPDVLILDEPTNNLDIESIDALAEAINEYE 838
                 .||||:   :::.||||||.::.||......|.:::||||||.||.:|:.||::|:..:|
Yeast   882 LGLDSELVSHS---RIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFE 943

  Fly   839 GGVIIVSHDERLIRETGCTLYVIEDQTI-----NEIVG-------EFDDYRKEVLDSLGEVVNN 890
            |||||::|.....:.....::.::|..:     |.:.|       |..:...:..|::|..:|:
Yeast   944 GGVIIITHSAEFTKNLTDEVWAVKDGKMTPSGHNWVAGQGAGPRIEKKEEEGDKFDAMGNKINS 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1703	NP_001285130.1	Uup	351..879	CDD:223562	175/689 (25%)
		ABCF_EF-3	352..573	CDD:213188	73/249 (29%)
		ABC_tran_Xtn	567..>611	CDD:289608	15/43 (35%)
		ABCF_EF-3	676..865	CDD:213188	76/303 (25%)
HEF3	NP_014384.3	HEAT repeat	129..158	CDD:293787	6/29 (21%)
		HEAT repeat	170..200	CDD:293787	5/34 (15%)
		HEAT repeat	208..232	CDD:293787	3/23 (13%)
		HEAT repeat	244..273	CDD:293787	4/28 (14%)
		4HB	336..411	CDD:407796	8/74 (11%)
		Uup	429..986	CDD:223562	172/656 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810