Protein Alignment CG1703 and YEF3

DIOPT Version :10

• Sequence 1: NP_572736.1
• Gene: CG1703 / 32112
• FlyBaseID: FBgn0030321
• Length: 901
• Species: Drosophila melanogaster
• Sequence 2: NP_013350.1
• Gene: YEF3 / 850951
• SGDID: S000004239
• Length: 1044
• Species: Saccharomyces cerevisiae
• Alignment Length: 972
• Identity: 219/972 - (22%)
• Similarity: 346/972 - (35%)
• Gaps: 370/972 - (38%)

  Fly   158 NEEDEVEVV----------AVKPASKKS---------KKKQQAQQK-----NMFAMSDDEEDEVA 198
            |::.|::.|          ||.|.:.|:         .:..:.|:|     .:.||.|..:|:||
Yeast   101 NKDKEIQSVASETLISIVNAVNPVAIKALLPHLTNAIVETNKWQEKIAILAAISAMVDAAKDQVA 165

  Fly   199 DDLPN----------DSEEEEKEQLSNKAAKESKKEQQKQPEKEV--------EEQKVEQVLSEK 245
            ..:|.          |:::|.|...:....|.::....|..|:.:        :..:|.:.:...
Yeast   166 LRMPELIPVLSETMWDTKKEVKAAATAAMTKATETVDNKDIERFIPSLIQCIADPTEVPETVHLL 230

  Fly   246 VAAVSLKEKTPEPVPKAEP-------EPES------------------EPQ-------------- 271
            .|...:.|.||..:....|       |.|:                  :||
Yeast   231 GATTFVAEVTPATLSIMVPLLSRGLNERETGIKRKSAVIIDNMCKLVEDPQVIAPFLGKLLPGLK 295

  Fly   272 ------PDEEADAEV----------------DSKFEESKEAKEKKLTHKEKKKQKKQQEYERQME 314
                  .|.|| .||                |....|...|.:...|.:...:..|.:....:.:
Yeast   296 SNFATIADPEA-REVTLRALKTLRRVGNVGEDDAIPEVSHAGDVSTTLQVVNELLKDETVAPRFK 359

  Fly   315 LMTKKGGAGHSDLDNNFTMSQV---------------QKSAGQKAALEQAVDIKIENFTISA--- 361
            ::.:...|..:||.:...:.|.               :|.|  |..|::.....::|..:..
Yeast   360 IVVEYIAAIGADLIDERIIDQQAWFTHITPYMTIFLHEKKA--KDILDEFRKRAVDNIPVGPNFD 422

  Fly   362 ----KGNDLFVNANLLIAHG---------------RRYGLVGPNGHGKTTLLRHIA---TRAFAI 404
                :|.|| .|....:|:|               ||||:.||||.||:||:|.||   ...|..
Yeast   423 DEEDEGEDL-CNCEFSLAYGAKILLNKTQLRLKRARRYGICGPNGCGKSTLMRAIANGQVDGFPT 486

  Fly   405 PPNIDVLLCEQEVVAT--DKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAEL 467
            ......:..|.::..|  |.:.::.:.|:.|...|.:|                     |...|
Yeast   487 QEECRTVYVEHDIDGTHSDTSVLDFVFESGVGTKEAIK---------------------DKLIE- 529

  Fly   468 KAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLEPTLLMLDEPTNHLDL 532
                              .||:.||...|.:..||||:|:::||||:.....:|:|||||||||.
Yeast   530 ------------------FGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDT 576

  Fly   533 NAVIWLDNYLQGWKKTLLIVSHDQSFLDNVCNEIIHLDQKKLQYYKGNYSMFKKMYVQKRREMIK 597
            ..|.||.|||.....|.:.:|||..||||||..||:.:..||:.||||::.|
Yeast   577 VNVAWLVNYLNTCGITSITISHDSVFLDNVCEYIINYEGLKLRKYKGNFTEF------------- 628

  Fly   598 EYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFR 662
                             .||....|..|.|:...                           ::|:
Yeast   629 -----------------VKKCPAAKAYEELSNTD---------------------------LEFK 649

  Fly   663 FPEPSQL------QPPILGVHNVTFAFP-SQKPLFIKVDFGIDLTSRVAIVGPNGVGKSTFLKLL 720
            ||||..|      |..|:.|.|:.|.:| :.||....::|...|:||:|::||||.||||.:.:|
Yeast   650 FPEPGYLEGVKTKQKAIVKVTNMEFQYPGTSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVL 714

  Fly   721 LGELEPQEGEQRKNHRLHVGRFDQHSGEHL-----------------TAE-------------ES 755
            .|||.|..||...:....:....||:..|:                 |.|             |:
Yeast   715 TGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINEN 779

  Fly   756 AAEYLQRLFNL------------------------------------------------------ 766
            .||.:.::|.:
Yeast   780 DAEAMNKIFKIEGTPRRIAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWIPRGE 844

  Fly   767 ---PHEK------ARKALGS-----------------FGL----VSHAHTIKMKDLSGGQKARVA 801
               .|.|      .::||.|                 .||    |||:   :::.||||||.::.
Yeast   845 LVESHSKMVAEVDMKEALASGQFRPLTRKEIEEHCSMLGLDPEIVSHS---RIRGLSGGQKVKLV 906

  Fly   802 LAELCLSAPDVLILDEPTNNLDIESIDALAEAINEYEGGVIIVSHDERLIRETGCTLYVIED 863
            ||......|.:::||||||.||.:|:.||::|:.|:||||||::|.....:.....::.::|
Yeast   907 LAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKNLTEEVWAVKD 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1703	NP_572736.1	Uup	354..878	CDD:440254	169/658 (26%)
YEF3	NP_013350.1	HEAT repeat	129..158	CDD:293787	4/28 (14%)
		HEAT repeat	170..200	CDD:293787	4/29 (14%)
		HEAT repeat	208..232	CDD:293787	1/23 (4%)
		HEAT repeat	244..273	CDD:293787	3/28 (11%)
		4HB	336..411	CDD:407796	10/76 (13%)
		Uup	437..973	CDD:440254	164/632 (26%)
		CD_eEF3	794..861	CDD:349276	2/66 (3%)