DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1703 and Abcf1

DIOPT Version :9

Sequence 1:	NP_001285130.1	Gene:	CG1703 / 32112	FlyBaseID:	FBgn0030321	Length:	901	Species:	Drosophila melanogaster
Sequence 2:	NP_038882.1	Gene:	Abcf1 / 224742	MGIID:	1351658	Length:	837	Species:	Mus musculus

Alignment Length:	899	Identity:	452/899 - (50%)
Similarity:	579/899 - (64%)	Gaps:	90/899 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LEKVQEKKPP------------TSKKGGKKGKRGGGGGDSSDEDVTTRNR---DNEDLESIASSN 68
            :.|..:::||            .:.|..||||:......:..|::...::   :.|.|:......
Mouse     1 MPKGPKQQPPEPEWIGDGEGTSPADKVVKKGKKDKKTKKTFFEELAVEDKQAGEEEKLQKEKEQQ 65

  Fly    69 QSKQQTAGKKQAKKGKKGKRNNDWSDE----DEKPEKSLPANDLDDEDDDEAPLASKPAAKKPQP 129
            |.:||...|:..:||::.|..:|.|||    :...:.|:||:|.:||              .|.|
Mouse    66 QQQQQQKKKRDTRKGRRKKDVDDDSDERVLMERLKQLSVPASDEEDE--------------VPAP 116

  Fly   130 SKKNKKNKKKNDDFSDEDKPELDLDDLDNEEDEVEVVAVKPASKKSKKKQQAQQKNMFAMSDDEE 194
            ..:.:|..|..:.|.     .|..||.:.||:|.|...:|||..:..:..:|
Mouse   117 IPRGRKKAKGGNVFE-----ALIQDDSEEEEEEEENRVLKPAKPEKNRINKA------------- 163

  Fly   195 DEVADDLPNDSEEEEKEQLSNKAAKESKKEQQKQPEKEVEEQKVEQVLSEKVAAVSLKEKTPEPV 259
              ||::.|....::.||:.|...||........:.|:|.|:              :.|||.|...
Mouse   164 --VAEEPPGLRSKKGKEEKSKGKAKSKPAAADSEGEEEEED--------------TAKEKEPPQQ 212

  Fly   260 PKAEPEPESEPQPDEEADAEVDSKFEESKEAKEK------KLTHKEKKKQKKQQEYERQMELMTK 318
            .|...:.|:|....||         :|.||...|      .|:.|||||.|||.:||||:|.:..
Mouse   213 GKDRDKKEAEQGSGEE---------KEEKEGDLKANDPYANLSKKEKKKLKKQMDYERQVESLKA 268

  Fly   319 KGGAGHSDLDNNFTMSQVQKSAGQKAALEQAVDIKIENFTISAKGNDLFVNANLLIAHGRRYGLV 383
            ...|     :|:|::||.:.|:.| |.||.|.|||:|.|:|||.|.:|||||:|.|..|||||||
Mouse   269 ANAA-----ENDFSVSQAEVSSRQ-AMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV 327

  Fly   384 GPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQ 448
            ||||.||||||:|||.||.:||||||||||||||||.:..|:..:|.||.:|..:|::...|:.|
Mouse   328 GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLRLLEEERRLQGQ 392

  Fly   449 FVAGDLTVQEELNDTFAELKAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARA 513
            ...||.|..|:|...:.||:|.||.:|||:||||||||||..|||:|||.|||||||||||||||
Mouse   393 LEQGDDTAAEKLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARA 457

  Fly   514 LYLEPTLLMLDEPTNHLDLNAVIWLDNYLQGWKKTLLIVSHDQSFLDNVCNEIIHLDQKKLQYYK 578
            |::||||||||||||||||||||||:||||||:||||||||||.|||:||.:|||||.::|.||:
Mouse   458 LFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDTQRLHYYR 522

  Fly   579 GNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDE 643
            |||..|||||.||::|::|:||||||:|:||||.|:|.|.|||:.||.|||||:|.:.|.|.::.
Mouse   523 GNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEVLTRKQQKCRRKNQDEES 587

  Fly   644 DEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTSRVAIVGP 708
            .| |.|||.|||||.|:|.||:|..|.||:||:|.|||.:..|||||..:|||||:.||:.||||
Mouse   588 QE-PPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYEGQKPLFKNLDFGIDMDSRICIVGP 651

  Fly   709 NGVGKSTFLKLLLGELEPQEGEQRKNHRLHVGRFDQHSGEHLTAEESAAEYLQRLFNLPHEKARK 773
            |||||||.|.||.|:|.|..||.||||||.:|.|:|...|.|..||:..|||||.||||::.|||
Mouse   652 NGVGKSTLLLLLTGKLTPTNGEMRKNHRLKIGFFNQQYAEQLHMEETPTEYLQRSFNLPYQDARK 716

  Fly   774 ALGSFGLVSHAHTIKMKDLSGGQKARVALAELCLSAPDVLILDEPTNNLDIESIDALAEAINEYE 838
            .||.|||.||||||::..|||||||||..|||....|||||||||||||||||||||.||||:|:
Mouse   717 CLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINDYK 781

  Fly   839 GGVIIVSHDERLIRETGCTLYVIEDQTINEIVGEFDDYRKEVLDSLGEV-VNNP 891
            |.||:||||.|||.||.|.|:|:|:|.:::|.|:||||::|||::|||| ||.|
Mouse   782 GAVIVVSHDARLITETNCQLWVVEEQGVSQIDGDFDDYKREVLEALGEVMVNRP 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1703	NP_001285130.1	Uup	351..879	CDD:223562	349/527 (66%)
		ABCF_EF-3	352..573	CDD:213188	154/220 (70%)
		ABC_tran_Xtn	567..>611	CDD:289608	28/43 (65%)
		ABCF_EF-3	676..865	CDD:213188	125/188 (66%)
Abcf1	NP_038882.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256		75/311 (24%)
		Uup	294..825	CDD:223562	351/531 (66%)
		ABCF_EF-3	296..517	CDD:213188	154/220 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..599		27/48 (56%)
		ABCF_EF-3	619..808	CDD:213188	125/188 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849476
Domainoid	1	1.000	215	1.000	Domainoid score	I2708
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H849
Inparanoid	1	1.050	804	1.000	Inparanoid score	I494
Isobase	1	0.950	-	0	Normalized mean entropy	S789
OMA	1	1.010	-	-		QHG53504
OrthoDB	1	1.010	-	-		D249617at33208
OrthoFinder	1	1.000	-	-		FOG0006074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104427
Panther	1	1.100	-	-	LDO	PTHR19211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3772
SonicParanoid	1	1.000	-	-		X4371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750