Protein Alignment CG2247 and Fbxo41

DIOPT Version :10

• Sequence 1: NP_572735.1
• Gene: CG2247 / 32111
• FlyBaseID: FBgn0030320
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_001101341.1
• Gene: Fbxo41 / 312504
• RGDID: 1566130
• Length: 873
• Species: Rattus norvegicus
• Alignment Length: 1005
• Identity: 189/1005 - (18%)
• Similarity: 308/1005 - (30%)
• Gaps: 391/1005 - (38%)

  Fly   142 QRERHREPSTHRDDLEPCDLGLMGWTGEFPKLTPISNIESNSDKEPLSTA------------KPG 194
            :.:|.|..|:.|..||        ::..:..|..:|...|..|....:.|            :|.
  Rat    15 EHKRFRSLSSLRAHLE--------YSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPA 71

  Fly   195 VL---PWSGLKVFPRVEPQ-EETAAGTTKPA--HITNKSEEQQQQPSLTTPIMTSPLD------- 246
            .|   |.:..:||.....| :|.|||.. ||  |:.:.....       .|:...|.|
  Rat    72 ALLAVPGARREVFESTSFQGKEQAAGPA-PAGPHLLHHHHHH-------APLAHFPGDLVPASLP 128

  Fly   247 ----ASQGELDAA------IKSPLN---AKKSPNATGIAT----------TSKSSTTPTNMQPSD 288
                |..|.:.||      |:.||.   |:||..::..:|          :..:|.:|.:..|:|
  Rat   129 CEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCSGPTSASPASPSPAD 193

  Fly   289 --------------------------LYNQVEDK------------------------------- 296
                                      |..:||.|
  Rat   194 VAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGR 258

  Fly   297 -KEDTTKKQAEADHTLHKSLKDARIVKRSMSTHSPPEHSRRSVRFSSHTPLTDETNIMKETSTET 360
             ||:..::.:|....:..|::....:|:.: .|...|.||:............|| ..:|.|.:.
  Rat   259 EKEELEERASELSRQVDVSVELLASLKQDL-VHKEQELSRKQQEVVQIDQFLKET-AAREASAKL 321

  Fly   361 SLKVIFERLKQTG--VERDLFIPSSENPRPRSNGSPVPKVAEMEHVAVVKCKTVAKQGAVVKGKA 423
            .|:...|.|.:..  .||.|.:.||      |.|| .|..            ::.:.|.......
  Rat   322 RLQQFIEELLERADRAERQLQVISS------SCGS-TPSA------------SLGRGGGGSASGP 367

  Fly   424 GLANPSNVM-----PQTPALTVTGKRVSKPKVPKGASPPSEGWTS----------TRAVKG---- 469
            ||..|..:.     |..|:.....:..|.|.....:..|:...:|          .|..:|
  Rat   368 GLRGPGRMREHHAGPAVPSTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRQEEGPSED 432

  Fly   470 ------NSRADYTNSSSCGSPIGNTNIRRRRAHAKAAPDKSKPCVRCAASVHPSGPKLCKKCIYE 528
                  .|||..||..|                     ::|:|         |....|.::.|
  Rat   433 SGPGGLGSRAQATNGGS---------------------ERSQP---------PRSSGLRRQAI-- 465

  Fly   529 KGYANKKWMKKTGGNEDHYDDDDDSDFSMIEVTLENEISVQQAEKKQLENVNKQTVIKEQEVVVI 593
                 :.|.::...:....::.|.||                        |..:|...|.|....
  Rat   466 -----QNWQRRPRRHSTEGEEGDVSD------------------------VGSRTTESEAEGPSD 501

  Fly   594 GGRKAIAIIADPIGCNLKVIP------NRQNLAGLKKISKDKCSSSLVQSLGDCHIGCQIVMAVM 652
            ..|...|:......|.|...|      .|:...|....|.:..|..::          ::..|:.
  Rat   502 VPRPGPAVAGPLNSCRLSARPEGGSGRGRRMERGSPSRSNEVISPEIL----------KMRAALF 556

  Fly   653 KIMTMKDR---VNMAQVCKTWAMISQDKSVWRTVMLRDTHISNWPRFIRELANNCTRELDM-LGV 713
            .|.|..|.   ::.|:||:.|..:::..:||..|:|.:..:.:  :|:..||..||:...: |..
  Rat   557 CIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCS--KFLAMLAQWCTQAHSLTLQN 619

  Fly   714 ILPNPPD---------------ILATLDISVLKA----LRVLRT--CP--VDDQFLFKVFRELPQ 755
            :.|....               :.|.|: |:|||    |.:||.  ||  :.|:.|:
  Rat   620 LKPRQRGKKESKEEYARSTRGCLEAGLE-SLLKAAGGNLLILRISHCPNILTDRSLW-------- 675

  Fly   756 LLELRAICYSPTFNFLNLARQWSKIRVLQILMTDHRSKV-----ESLDSLGDLVHLTELNIRGVN 815
                .|.||               .|.||.:  .:||..     |.:.:||
  Rat   676 ----LASCY---------------CRALQAV--TYRSATDPVGHEVIWALG-------------- 705

  Fly   816 YIGSQDFRFLKKLVNLKVLVLSSCQGMDTEEFGQQVLPFLTSLRRLRLENK--HMINTTFPLYHI 878
             .|.:|      :|:|:|..|..||                  :..|..|:  .||...:|  |:
  Rat   706 -AGCRD------IVSLQVAPLHPCQ------------------QPTRFSNRCLQMIGRCWP--HL 743

  Fly   879 MC-GV-AAACSVQQL--------ELVNVEVDDL------------------LTSLIGMCTTVTHL 915
            .. || .|.|.||.|        .|..:|:|.:                  |..|:...|.||
  Rat   744 RALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVT-- 806

  Fly   916 LLVPKCLQNSANVIYSVMRAVRENASQLRV 945
               ||.|.:    ..|:.|.::....|:.:
  Rat   807 ---PKALLH----FNSICRNLKSIVVQIGI 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2247	NP_572735.1	PRK08581	90..>379	CDD:236304	64/344 (19%)
		F-box_SF	646..682	CDD:459239	10/38 (26%)
Fbxo41	NP_001101341.1	Smc	<200..>342	CDD:440809	22/143 (15%)
		CwlO1	209..512	CDD:443091	62/384 (16%)
		F-box_FBXO41	545..591	CDD:438881	11/55 (20%)
		leucine-rich repeat	657..683	CDD:275381	10/52 (19%)
		leucine-rich repeat	684..710	CDD:275381	8/42 (19%)
		leucine-rich repeat	711..742	CDD:275381	11/50 (22%)
		leucine-rich repeat	743..767	CDD:275381	7/23 (30%)
		leucine-rich repeat	768..794	CDD:275381	3/25 (12%)
		leucine-rich repeat	795..819	CDD:275381	9/32 (28%)