Protein Alignment CG2247 and FBXO41

DIOPT Version :10

• Sequence 1: NP_572735.1
• Gene: CG2247 / 32111
• FlyBaseID: FBgn0030320
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_001073879.2
• Gene: FBXO41 / 150726
• HGNCID: 29409
• Length: 875
• Species: Homo sapiens
• Alignment Length: 1000
• Identity: 184/1000 - (18%)
• Similarity: 309/1000 - (30%)
• Gaps: 379/1000 - (37%)

  Fly   142 QRERHREPSTHRDDLEPCDLGLMGWTGEFPKLTPISNIESNSDKEPLSTA------------KPG 194
            :.:|.|..|:.|..||        ::..:..|..:|...|..|....:.|            :|.
Human    15 EHKRFRSLSSLRAHLE--------YSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPA 71

  Fly   195 VL---PWSGLKVFPRVEPQ-EETAAGTTKPA-HITNKSEEQQQQPSLTTPIMTSPLD-------- 246
            .|   |.:..:||.....| :|.|||.:..| |:.:.....       .|:...|.|
Human    72 ALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHH-------APLAHFPGDLVPASLPC 129

  Fly   247 ---ASQGELDAA--------IKSPLN---AKKSPNATGIAT----------TSKSSTTPTNMQPS 287
               |..|.:.||        |:.||.   |:||..::..:|          ...:|.:|.:..|:
Human   130 EELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPA 194

  Fly   288 D--------------------------LYNQVEDK------------------------------ 296
            |                          |..:||.|
Human   195 DVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLG 259

  Fly   297 --KEDTTKKQAEADHTLHKSLKDARIVKRSMSTHSPPEHSRRSVRFSSHTPLTDETNIMKETSTE 359
              ||:..::.:|....:..|::....:|:.: .|...|.||:............|| ..:|.|.:
Human   260 REKEELEERASELSRQVDVSVELLASLKQDL-VHKEQELSRKQQEVVQIDQFLKET-AAREASAK 322

  Fly   360 TSLKVIFERLKQTG--VERDLFIPSSENPRPRSNGSPVPKVAEMEHVAVVKCKTVAKQGAVVKGK 422
            ..|:...|.|.:..  .||.|.:.||                        .|.:.........|.
Human   323 LRLQQFIEELLERADRAERQLQVISS------------------------SCGSTPSASLGRGGG 363

  Fly   423 AGLANPS----------NVMPQTPALTVTGKRVSKPKVPKGASPPSEGWTSTRAVKGNSRADYTN 477
            .|.|.|:          :|.|..|         :...|.:..|.||.|.:|.......|...|.:
Human   364 GGGAGPNARGPGRMREHHVGPAVP---------NTYAVSRHGSSPSTGASSRVPAASQSSGCYDS 419

  Fly   478 SS------SCGSP--IGNTNIRRRRAHAKAAPDKSKPCVRCAASVHPSGPKLCKKCIYEKGYANK 534
            .|      ..|:|  .|...:..|...|....::|:|         |....|.::.|       :
Human   420 DSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQP---------PRSSGLRRQAI-------Q 468

  Fly   535 KWMKKTGGNEDHYDDDDDSDFSMIEVTLENEISVQQAEKKQLENVNKQTVIKEQEVVVIGGRKAI 599
            .|.::...:....::.|.||                        |..:|...|.|..:...|...
Human   469 NWQRRPRRHSTEGEEGDVSD------------------------VGSRTTESEAEGPLDAPRPGP 509

  Fly   600 AIIADPIGCNL---------------KVIPNRQNLAGLKKISKDKCSSSLVQSLGDCHIGCQIVM 649
            |:......|.|               :|.|:|.|.....:|.|.:.:                :.
Human   510 AMAGPLSSCRLSARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAA----------------LF 558

  Fly   650 AVMKIMTMKDRVNMAQVCKTWAMISQDKSVWRTVMLRDTHISNWPRFIRELANNCTRELDM-LGV 713
            .:...:..:..::.|:||:.|..:::..:||..|:|.:..:.:  :|:..||..||:...: |..
Human   559 CIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCS--KFLAMLAQWCTQAHSLTLQN 621

  Fly   714 ILPNPPD---------------ILATLDISVLKA----LRVLRT--CP--VDDQFLFKVFRELPQ 755
            :.|....               :.|.|: |:|||    |.:||.  ||  :.|:.|:
Human   622 LKPRQRGKKESKEEYARSTRGCLEAGLE-SLLKAAGGNLLILRISHCPNILTDRSLW-------- 677

  Fly   756 LLELRAICYSPTFNFLNLARQWSKIRVLQILMTDHRSKVESLDSLGDLVHLTELNIRGVNYIGSQ 820
                .|.||               .|.||.:  .:||   :.|.:|..|         :..:|:.
Human   678 ----LASCY---------------CRALQAV--TYRS---ATDPVGHEV---------IWALGAG 709

  Fly   821 DFRFLKKLVNLKVLVLSSCQGMDTEEFGQQVLPFLTSLRRLRLENK--HMINTTFPLYHIMC-GV 882
                .:::|:|:|..|..||                  :..|..|:  .||...:|  |:.. ||
Human   710 ----CREIVSLQVAPLHPCQ------------------QPTRFSNRCLQMIGRCWP--HLRALGV 750

  Fly   883 -AAACSVQQL--------ELVNVEVDDL------------------LTSLIGMCTTVTHLLLVPK 920
             .|.|.||.|        .|..:|:|.:                  |..|:...|.||     ||
Human   751 GGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVT-----PK 810

  Fly   921 CLQNSANVIYSVMRAVRENASQLRV 945
            .|.:    ..|:.|.::....|:.:
Human   811 ALLH----FNSICRNLKSIVVQIGI 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2247	NP_572735.1	PRK08581	90..>379	CDD:236304	63/345 (18%)
		F-box_SF	646..682	CDD:459239	6/35 (17%)
FBXO41	NP_001073879.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	85..110		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..194		3/28 (11%)
		Smc	<202..>344	CDD:440809	22/143 (15%)
		CwlO1	211..491	CDD:443091	57/354 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..542		43/267 (16%)
		F-box_FBXO41	547..593	CDD:438881	8/61 (13%)
		leucine-rich repeat	659..685	CDD:275381	10/52 (19%)
		leucine-rich repeat	686..712	CDD:275381	8/43 (19%)
		leucine-rich repeat	713..744	CDD:275381	11/50 (22%)
		leucine-rich repeat	745..769	CDD:275381	7/23 (30%)
		leucine-rich repeat	770..796	CDD:275381	3/25 (12%)
		leucine-rich repeat	797..821	CDD:275381	9/32 (28%)