DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho-4 and RHBDF2

DIOPT Version :9

Sequence 1:	NP_525084.1	Gene:	rho-4 / 32109	FlyBaseID:	FBgn0030318	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_078875.4	Gene:	RHBDF2 / 79651	HGNCID:	20788	Length:	856	Species:	Homo sapiens

Alignment Length:	199	Identity:	38/199 - (19%)
Similarity:	90/199 - (45%)	Gaps:	17/199 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 NPYKRYEGWRFVSYMFVHVGIMHLMMNLIIQIFLGIALELVHHWWRVGLVYLAGVLAGSMGTSLT 289
            ||....:.:|....:|:|.|::|.:::::.|:.:...||.:..|.|:.::::...:.|::.:::.
Human   647 NPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIF 711

  Fly   290 SPRIFLAGASGGVYALITAHIATIIMNYSEME---YAIVQLLAFLVFCFTDLGTSVYRHLTDQHD 351
            .|.....|.:|..:.|:......:..::..:|   .|.:.|.|.::|.|          :.....
Human   712 LPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLF----------ICGLLP 766

  Fly   352 QIGYVAHLSGAVAGLLVGIGVLRNLEV----RRWERILWWVAVIVYFALMTTGIIIHVFVPDYFP 412
            .|..:||:.|.::|||:....|..:..    :..:|.|..|:::.:..|....::.....|..:|
Human   767 WIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFAGLFAALVLWLYIYPINWP 831

  Fly   413 KQEY 416
            ..|:
Human   832 WIEH 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-4	NP_525084.1	EFh_HEF	<57..197	CDD:355006
		EFh	73..134	CDD:238008
		Rhomboid	226..374	CDD:396315	29/150 (19%)
RHBDF2	NP_078875.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		Rhomboid_SP	128..334	CDD:289371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..184
		Involved in interaction with FRMD8. /evidence=ECO:0000269\|PubMed:29897333	191..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..553
		Rhomboid	648..789	CDD:279958	29/150 (19%)
		GtrA	748..832	CDD:303012	18/93 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820