DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho-4 and Rhbdf2

DIOPT Version :9

Sequence 1:	NP_525084.1	Gene:	rho-4 / 32109	FlyBaseID:	FBgn0030318	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	XP_030101763.1	Gene:	Rhbdf2 / 217344	MGIID:	2442473	Length:	853	Species:	Mus musculus

Alignment Length:	424	Identity:	74/424 - (17%)
Similarity:	163/424 - (38%)	Gaps:	93/424 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QQLQ--LQQQRDVENGLYPTIPAERRSPPSRPQTLRQDTIDMEEIPLNQTNSQEPEDRRKMHEIF 78
            ||::  ::::||:|......:..:|   ....|||::|..:.....:...|...|.|:..:.:
Mouse   479 QQIEQLVRRERDIERTSGCCVQNDR---SGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQ-- 538

  Fly    79 DKHDSDRDGLINTHE----LKELISDGYCRDIPAYI-ADQILK------RSDQDNDG--HLDFE- 129
                 .:...:..|:    .:|..|.|      |:| .|.|.|      ::..::.|  |:|.:
Mouse   539 -----KQPSAVVCHQDPRTCEEPASSG------AHIWPDDITKWPICTEQAQSNHTGLLHIDCKI 592

  Fly   130 EFYAMSLRHKWMVRNMLTRYCRYVVPPPKPLEGDEPDGAYEKQMSICPPPLTMVLFSIIEIIMFL 194
            :.....:..|.........||.::            .|.:.:..::|..  ...|..:..::.||
Mouse   593 KGRPCCIGTKGSCEITTREYCEFM------------HGYFHEDATLCSQ--VHCLDKVCGLLPFL 643

  Fly   195 VDVIHFQDDPNYQDRIGESTSGPAATLFIYNPYKRYEGWRFVSYMFVHVGIMHLMMNLIIQIFLG 259
                    :|...|:.                   |..|   ..:|:|.||:|.:::::.|:.:.
Mouse   644 --------NPEVPDQF-------------------YRIW---LSLFLHAGIVHCLVSVVFQMTIL 678

  Fly   260 IALELVHHWWRVGLVYLAGVLAGSMGTSLTSPRIFLAGASGGVYALITAHIATIIMNYSEME--- 321
            ..||.:..|.|:.::::...:.|::.:::..|.....|.:|..:.|:......:..::..:|
Mouse   679 RDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPW 743

  Fly   322 YAIVQLLAFLVFCFTDLGTSVYRHLTDQHDQIGYVAHLSGAVAGLLVGIGVLRNLEV----RRWE 382
            .|...|.|.::|.|          :......|..:||:.|.::|:|:....|..:..    :..:
Mouse   744 KAFFNLSAIVLFLF----------ICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRK 798

  Fly   383 RILWWVAVIVYFALMTTGIIIHVFVPDYFPKQEY 416
            |.|..|:::|:..|..:.::.....|..:|..||
Mouse   799 RALILVSLLVFAGLFASLVLWLYIYPINWPWIEY 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-4	NP_525084.1	EFh_HEF	<57..197	CDD:355006	23/153 (15%)
		EFh	73..134	CDD:238008	12/74 (16%)
		Rhomboid	226..374	CDD:396315	29/150 (19%)
Rhbdf2	XP_030101763.1	Rhomboid_SP	98..328	CDD:372211
		Rhomboid	648..788	CDD:366759	31/171 (18%)
		MFS	746..>836	CDD:391944	20/97 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820