Protein Alignment rho-4 and RHBDL3

DIOPT Version :9

• Sequence 1: NP_525084.1
• Gene: rho-4 / 32109
• FlyBaseID: FBgn0030318
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_001350764.1
• Gene: RHBDL3 / 162494
• HGNCID: 16502
• Length: 428
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 72/278 - (25%)
• Similarity: 125/278 - (44%)
• Gaps: 53/278 - (19%)

  Fly    37 ERRSP-PSRPQTLRQDTIDMEEIPLNQTNSQEPEDRRKMHEIFDKHDSDRDGLINTHELKELISD 100
            |..|| |:.......:.|:..|....:.....|||..|:  :||:.|....|.|:|.:.:.|: :
Human     3 EHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKV--LFDQFDPGNTGYISTGKFRSLL-E 64

  Fly   101 GYCRDIPAYIADQILKRSDQDNDGHLDFEEFYAM-------SLRHKWMVRN-------------- 144
            .:...:..:..:.:|..:|...||.:.:::|.::       |.|...:..|
Human    65 SHSSKLDPHKREVLLALADSHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGL 129

  Fly   145 -MLTRYCRYVVPPPKPLEGDEPDGAYEKQMSICPPPLTMVLFSIIEIIMFL----------VDVI 198
             :..|..|:|.....|.|.|..  .|....:.||||..|:..:::|:..||          :.|.
Human   130 SLSQRLIRHVAYETLPREIDRK--WYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVT 192

  Fly   199 HFQDDPNYQDRIGESTSGPAATLFIYNPYKRYEGWRFVSYMFVHVGIMHLMMNLIIQIFLGIALE 263
            |    |.|           .....:|:|..|.:.||:::|:|:|.||.||.:|:::|:.:|:.||
Human   193 H----PRY-----------LKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLE 242

  Fly   264 LVHHWWRVGLVYLAGVLA 281
            :||...|:||||:|||:|
Human   243 MVHGATRIGLVYVAGVVA 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rho-4	NP_525084.1	EFh_HEF	<57..197	CDD:355006	35/171 (20%)
		EFh	73..134	CDD:238008	13/60 (22%)
		Rhomboid	226..374	CDD:396315	27/56 (48%)
RHBDL3	NP_001350764.1	EF-hand_7	36..100	CDD:316058	15/66 (23%)
		EF-hand motif	38..67	CDD:320054	8/31 (26%)
		Rhomboid	205..>260	CDD:328780	26/54 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880