DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho-4 and rhbdf2

DIOPT Version :9

Sequence 1:	NP_525084.1	Gene:	rho-4 / 32109	FlyBaseID:	FBgn0030318	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_001090673.1	Gene:	rhbdf2 / 100036646	XenbaseID:	XB-GENE-966769	Length:	826	Species:	Xenopus tropicalis

Alignment Length:	379	Identity:	68/379 - (17%)
Similarity:	142/379 - (37%)	Gaps:	111/379 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SDRDGLINTHE--------------------LKEL-----ISDGYCR------DIPAYI-----A 111
            :|:.|.:.||.                    |.|:     .|...|.      :.||.|     |
Frog   474 NDKSGCVQTHRKDCSETLATFIKWPEHDAPVLDEVTGMKRTSGAVCHQDPRTCEEPASIQPHVWA 538

  Fly   112 DQILK------RSDQDNDG--HLDFE-EFYAMSLRHKWMVRNMLTRYCRYVVPPPKPLEGDEPDG 167
            |.|.|      ::..::.|  |:|.| :.....:..|.........||.::            .|
Frog   539 DDITKWPICTYQAMNNHTGIRHMDCEIKGRPCCIGTKGSCEITTREYCTFM------------HG 591

  Fly   168 AYEKQMSICPPPLTMVLFSIIEIIMFLVDVIHFQDDPNYQDRIGESTSGPAATLFIYNPYKRYEG 232
            .:.::.::|..  ...|..:..::.||        :|.|.|:.                   |..
Frog   592 YFHEEATLCSQ--VHCLDEVCGLLPFL--------NPEYPDQF-------------------YRL 627

  Fly   233 WRFVSYMFVHVGIMHLMMNLIIQIFLGIALELVHHWWRVGLVYLAGVLAGSMGTSLTSPRIFLAG 297
            |   ..:|:|.|::|..::::.|:.:...||.:..|.|:.::|:...:.|::.::|..|.....|
Frog   628 W---LSLFLHAGVIHCCVSVVFQMTVLRDLEKLAGWLRISIIYILSGITGNLASALFLPYRAEVG 689

  Fly   298 ASGGVYALITAHIATIIMNYSEME---YAIVQLLAFLVFCFTDLGTSVYRHLTDQHDQIGYVAHL 359
            .:|..:.|:......:..::..:.   .|.::||..::|.|          |......|..:||:
Frog   690 PAGSQFGLLACLFVELFQSWQILAKPWKAFLKLLGIVLFLF----------LFGLLPWIDNIAHI 744

  Fly   360 SGAVAGLLVGIGVLRNL------EVRRWERILWWVAVIVYFALMTTGIIIHVFV 407
            .|.::|||:....|..:      :.|:...|:  ::::|:..|..: ::|.::|
Frog   745 FGFLSGLLLSFSFLPYITFGTADKFRKRAMII--ISLLVFVGLFAS-LVIWLYV 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-4	NP_525084.1	EFh_HEF	<57..197	CDD:355006	27/158 (17%)
		EFh	73..134	CDD:238008	19/95 (20%)
		Rhomboid	226..374	CDD:396315	31/150 (21%)
rhbdf2	NP_001090673.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..78
		Rhomboid_SP	90..287	CDD:372211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180
		Rhomboid	620..761	CDD:366759	34/172 (20%)
		MFS	746..>803	CDD:391944	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920