back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pkm and nhr-246

DIOPT Version :10

Sequence 1:	NP_996412.1	Gene:	pkm / 32108	FlyBaseID:	FBgn0030317	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001256661.1	Gene:	nhr-246 / 191499	WormBaseID:	WBGene00014192	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	88/374 - (23%)
Similarity:	146/374 - (39%)	Gaps:	113/374 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 EDLPNEQVTQFLRQLVS---QLWPELGA-----NPEL----RLERASAKGDNYLGVVWRLQAASD 273
            |::|  ...::|.:|:.   .:.|::|.     |.||    .|.:.....||           .|
Worm     7 ENIP--LTKEWLAELIEIKIGVKPKIGTVGILENSELGFMSLLRKVRLHFDN-----------DD 58

  Fly   274 SKRSLVVKLPPQNRVRRKQFFARPCFLRETAAYEVFLPLTALIQDKWKIIGDDRFRQHALC---- 334
            ..:.:|:|: |||        .:.|.:.|.|...|.....:::         :||..:..|
Worm    59 LPKHVVLKI-PQN--------TKGCSVVENAGGGVKNVDHSVV---------ERFMHNTECNYYK 105

  Fly   335 -FGTRQDEPNE-----------------CIVLEDL-SCAGFSLHNRFLDLSVEHVRRVMLTYAKL 380
             |.:..::|.:                 .||||.| .|   .||:.....:.:.:.:::....||
Worm   106 LFSSLSEKPLQIPTTYLASKAGEKAPVPVIVLEMLEDC---KLHDLIPGFNEDQLFKIVDELVKL 167

  Fly   381 HAISLA---GKRQLPEKMQQ-----LQQLV-DIFEQRRDDHALGV---YFENLKESALSALLAPA 433
            |..||.   .|..:|::.:.     ||.:| |:..:...:..|||   |.||..::
Worm   168 HIFSLTTEKWKEIVPDESKLAMSGFLQCMVADVGRKLAQNPELGVILSYVENTLDT--------- 223

  Fly   434 DDAYRVRLEAYFARGSYFELLLPLVSGFNCEPFAVICHGDCWNNNILYKSTERGELED--VRLID 496
            |..|..::     |..|          .|.|..:||||||.|...||:      :.||  ..::|
Worm   224 DPNYLQKM-----RDEY----------INEERPSVICHGDLWAPQILW------DKEDNIAGIVD 267

  Fly   497 WQLMRYASPVTDLAYFLFTCTSRRFRQRHLENMLEDYYEELGLQLIRLG 545
            ||.....||:.||.:.|.||||.:.|:...:.:|:.||.:|.:.|...|
Worm   268 WQATHRGSPMEDLHHILSTCTSVQNRKTFTKPLLDHYYNKLKVGLKEKG 316

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.