Protein Alignment nod and KIF3B

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_004789.1
• Gene: KIF3B / 9371
• HGNCID: 6320
• Length: 747
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 166/697 - (23%)
• Similarity: 272/697 - (39%)
• Gaps: 185/697 - (26%)

  Fly    48 FHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM-GMTPPGEILPEHLG 111
            |.||..:.....|.|:|.....||||.:|:||..|..|||||||||:|:| |:.  |:  ||..|
Human    57 FTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIR--GD--PEKRG 117

  Fly   112 ILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLG-------STPHMPMVAARCQRC 169
            ::|.:...||..: :|.:|.:..::  ||::|||.|:..|||.       .....|......:..
Human   118 VIPNSFDHIFTHI-SRSQNQQYLVR--ASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDL 179

  Fly   170 TCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSK------THHSR---MNIV 225
            :.....|..::.|::.:|.:||.|..||||.:|||||||..|.::..      .:|.|   :|:|
Human   180 SSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLV 244

  Fly   226 DLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAG-HTVIPYRDSVLTTVLQASLTAQS 289
            ||||||...:||.:|...:|...|||.|.::..|:.::..| .|.||||||.||.:||.||...:
Human   245 DLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNA 309

  Fly   290 YLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM---------------QVARQKQSLAART- 338
            ....:|.:.|...::.|||:|||:...||.::..|.               ::||.|..|..|:
Human   310 KTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSI 374

  Fly   339 ----------------------------------------------THVFRQALCTSTAI----- 352
                                                          ..:.::|:....::
Human   375 GRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEK 439

  Fly   353 --------------------------KSNAANHNSIVVPKSKYSTTKPLSAVLHRTRSELGMTPK 391
                                      |..|.....:|..|:....|.....:|.:.|.|:.   :
Human   440 MRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIA---E 501

  Fly   392 AKKRAREL-----------LELEETTLEL-SSIHIQDSSLSLLGFHSDSDK-------DRHLMPP 437
            .|:|.||:           |||:||...| ..:.|:...|..|.....:.|       :.|:
Human   502 QKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHI--- 563

  Fly   438 PTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTT----------ISP 492
                :.||...|.        :.|.....|::..::...:|...:.::.|..          :.|
Human   564 ----KERQELEQT--------QNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHP 616

  Fly   493 ISLRASSSQRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLR-----RSTR 552
            |:        .|...|.|:..|.|...:..|.:..|::..:|.:.......::.|.     |:||
Human   617 IT--------RLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTR 673

  Fly   553 ------LAGIREHATSVVVKNETDAIPHLRSTVQKKRTRNVKPAPKA 593
                  :|...:.|....:::| |.|....|:.:....:..|..||:
Human   674 DYEGPAIAPKVQAALDAALQDE-DEIQVDASSFESTANKKSKARPKS 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	104/287 (36%)
		ComEA	606..>645	CDD:441164
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	106/289 (37%)
		Smc	<355..>581	CDD:440809	33/243 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		0/37 (0%)
		Globular	580..747		26/149 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..747		4/21 (19%)