DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and Kif4a

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_006257175.1	Gene:	Kif4a / 84393	RGDID:	620526	Length:	1231	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	178/693 - (25%)
Similarity:	289/693 - (41%)	Gaps:	162/693 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EGAKLSAVRIAVREAPYRQFLGRRE-----PSVVQFPPWSDGKSLIVDQNEFHFDHAFPATISQD 61
            |..|...||:|:|..|    |..:|     .:.:.|.| .:.:.::.....|.:|..|..:..|:
  Rat     3 EEVKGIPVRVALRCRP----LVSKEINEGCQTCLSFVP-GEPQVVVGTDKSFTYDFVFDPSTEQE 62

  Fly    62 EMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEH---LGILPRALGDIFER 123
            |::...:.||:..:.:|:..|.|||||||:||:||||.....|  .||   :|::||.:..:|:.
  Rat    63 EVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAE--QEHDSAIGVIPRVIQLLFKE 125

  Fly   124 VTARQENNKDAIQ--VYASFIEIYNEKPFDLL-----------------------GSTPHMPMVA 163
            :     |.|...:  :..|::|||||:..|||                       |.|....:||
  Rat   126 I-----NKKTDFEFTLKVSYLEIYNEEILDLLCSSREKASQINIREDPKEGIKIVGLTEKTVLVA 185

  Fly   164 ARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTHHSR 221
            :....|              ||.|...|.|..|.|||.|||||||.||.:       |:.:..|:
  Rat   186 SDTVSC--------------LEQGNNCRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSK 236

  Fly   222 MNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGH--TVIPYRDSVLTTVLQAS 284
            :::|||||||..::|..||...:||:|||.|||.:..|:.::....  ..:|||||.||.:||.|
  Rat   237 LHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDS 301

  Fly   285 LTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNP-MQVARQKQSLAARTTHVFRQALCT 348
            |...|:...:||:||...:|.|||:|||:...|:|::..| :.:..|    ||...|:.:|....
  Rat   302 LGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQ----AAELNHLKQQVQQL 362

  Fly   349 STAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRTRSELGMTPKAKKRARELLE--------LEET 405
            ...:   ...|...:........::.|.:::.:.:|   :..:.:|.:|.|.|        ||..
  Rat   363 QVLL---LQAHGGTLPGNINVKPSENLQSLMEKNQS---LVEENEKLSRGLSEAAGQTAQMLERI 421

  Fly   406 TLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIVEETEPKESSKV-- 468
            .|...:....::.|..|..|:....|.                  ..|...:|:.|.||:.::
  Rat   422 ILTEQANEKMNAKLEELRQHAACKVDL------------------QKLAETLEDQEVKENIEIIC 468

  Fly   469 -QQSMVAPTVPTTVRCQLFNTTI------------SPISLRAS---SSQRELSGIQPMEETVVAS 517
             .|..:|......|.|  ...||            ||.:.|:|   |:|..|...|..:|.:..:
  Rat   469 NLQQAIARLSDEAVAC--MTATIDTAGEVDTQEQSSPDTSRSSDVFSTQHALRQAQMSKELIELN 531

  Fly   518 PQQPCLRRSVRLASSMRSQNYGAIPKVM-----NLRR-STRLAGIREHATSVVVKNETDAIPHLR 576
            .:   |.....||..| :||...:..:.     |::. ...:..:::....:|::.:|
  Rat   532 KE---LALKEALAKKM-TQNDNQLQPIQFQYQDNIKNLELEVLSLQKEKEELVLELQT------- 585

  Fly   577 STVQKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVKQLQEIPG 619
               .||.....|                 |:....|:|||:.|
  Rat   586 ---AKKDVNQAK-----------------LSERRRKRLQELEG 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	119/359 (33%)
		KISc	8..318	CDD:276812	116/351 (33%)
		ComEA	540..648	CDD:224472	12/86 (14%)
Kif4a	XP_006257175.1	KISc_KIF4	8..338	CDD:276823	118/355 (33%)
		KISc	9..344	CDD:214526	119/360 (33%)
		HCR	390..1057	CDD:284517	50/273 (18%)
		COG4985	<494..638	CDD:227318	27/146 (18%)
		Cas1_I-II-III	<681..>744	CDD:294435
		Pre-SET	<1070..1120	CDD:282838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810