DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and KIF18A

DIOPT Version :10

Sequence 1:NP_511125.2 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_112494.3 Gene:KIF18A / 81930 HGNCID:29441 Length:898 Species:Homo sapiens


Alignment Length:760 Identity:171/760 - (22%)
Similarity:292/760 - (38%) Gaps:207/760 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 KSLIVDQN---EFHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM--G 98
            :::|..||   :|.||..|..|.:|.|:::....|::...|.|:.||.||||.||.||:::|  .
Human    62 QNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGS 126

  Fly    99 MTPPGEILPEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLL---------- 153
            ...||.:....|. |.:.:.:|.|         :.......|::|:|||:..|||          
Human   127 ADEPGVMYLTMLH-LYKCMDEIKE---------EKICSTAVSYLEVYNEQIRDLLVNSGPLAVRE 181

  Fly   154 ---------GSTPHMPMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIV 209
                     |.|.|.|              .|..::.|:|:.|.:||...||:||:.||||||:.
Human   182 DTQKGVVVHGLTLHQP--------------KSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVF 232

  Fly   210 TIHVKSK---------THHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAA 265
            .|:::.:         ...::|:::||||||....:|.:|....||.|||..||::..|:.::|.
Human   233 QIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALAD 297

  Fly   266 G---HTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAK----KLRLN 323
            .   :..||||:|.||.:|:.||........:|.:||......:|.:||::...||    .|:.|
Human   298 SKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSN 362

  Fly   324 PMQVARQ------------------KQSLAA---------------------------------- 336
            .:.|...                  |:.|.|                                  
Human   363 VLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILN 427

  Fly   337 ---------RTTHVFRQALCTSTAIKS--NAANHNSIVVPKSKYSTTKPLS------AVLHRTRS 384
                     |..::..:.|.....:||  ....|..|.:..|:....|...      |:|...||
Human   428 CLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRS 492

  Fly   385 ELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLG----FHSDSDKDRHLMPPPTGQEPRQ 445
            .|     .|:|..||.:.:|.|   :.:|..:..:.||.    ...:..||.|........:..:
Human   493 YL-----EKRREEELKQFDENT---NWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLK 549

  Fly   446 ASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVR--CQLFNTTISPISLRASSSQRELSGIQ 508
            |..::...:..::|.:.:::..|..::    :||..:  |.|....:|..:.  .|..:|:..:.
Human   550 AQIRHMMDLACLQEQQHRQTEAVLNAL----LPTLRKQYCTLKEAGLSNAAF--ESDFKEIEHLV 608

  Fly   509 PMEETVVASPQ---QPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIR-------EHATSV 563
            ..::.||.:.|   ||             .||  .:|.:..|....:|..::       ...|::
Human   609 ERKKVVVWADQTAEQP-------------KQN--DLPGISVLMTFPQLGPVQPIPCCSSSGGTNL 658

  Fly   564 VVKNETDAIPHLRSTVQKKRTRNVKPAP-------KAWMANNTKCFLDLLNNGNVKQLQEIPGIG 621
            |      .||     .:|:..|.:.|:|       |:..:.:.:     ||:...|:||.|. ..
Human   659 V------KIP-----TEKRTRRKLMPSPLKGQHTLKSPPSQSVQ-----LNDSLSKELQPIV-YT 706

  Fly   622 PKSAFSLALHRSRL-----GCFENLFQVKSLPIWSGNKWERFCQI 661
            |:.......:.|.:     ..|...||..|..|.|.|..:..|::
Human   707 PEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEV 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_511125.2 KISc 8..318 CDD:276812 93/314 (30%)
ComEA 606..>645 CDD:441164 11/43 (26%)
KIF18ANP_112494.3 KISc_KIP3_like 11..355 CDD:276821 95/316 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..690 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..871
Blue background indicates that the domain is not in the aligned region.

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